Krympt por-syndrom – ett nyupptäckt syndrom med hög prevalens och mortalitet
(2019) In Läkartidningen 116.- Abstract
Shrunken Pore Syndrome was defined in 2015 and is characterised by the glomerular filtration of 5-40 kDa molecules being selectively decreased compared to that of molecules <0.2 kDa, e.g. water and creatinine. The diagnose is based upon identification of a decreased eGFRcystatin C/eGFRcreatinine ratio, and ratios -< 0.6 or 0.7 have most often been used to identify the diagnose. The mortality is strongly increased in all investigated populations and increases progressively with a decrease in the eGFRcystatin C/eGFRcreatinine ratio used to identify the syndrome. The prevalence of the syndrome varies with the eGFRcystatin C/eGFRcreatinine ratio used for diagnosis, but when a ratio of 0.6 is used, the prevalence has varied between 2... (More)
Shrunken Pore Syndrome was defined in 2015 and is characterised by the glomerular filtration of 5-40 kDa molecules being selectively decreased compared to that of molecules <0.2 kDa, e.g. water and creatinine. The diagnose is based upon identification of a decreased eGFRcystatin C/eGFRcreatinine ratio, and ratios -< 0.6 or 0.7 have most often been used to identify the diagnose. The mortality is strongly increased in all investigated populations and increases progressively with a decrease in the eGFRcystatin C/eGFRcreatinine ratio used to identify the syndrome. The prevalence of the syndrome varies with the eGFRcystatin C/eGFRcreatinine ratio used for diagnosis, but when a ratio of 0.6 is used, the prevalence has varied between 2 and 8%. The pathophysiology might be the accumulation of atherosclerosis-promoting proteins occurring in patients with the syndrome. The syndrome might explain the superiority of eGFRcystatin C over eGFRcreatinine in identifying high-risk kidney patients.
(Less)
- author
- Grubb, Anders LU
- organization
- alternative title
- Shrunken Pore Syndrome - a new syndrome
- publishing date
- 2019-05-28
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Läkartidningen
- volume
- 116
- publisher
- Swedish Medical Association
- external identifiers
-
- pmid:31192397
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- id
- 88a1fd2d-250c-4736-8f4f-705d3377bd44
- alternative location
- http://lakartidningen.se/Klinik-och-vetenskap/Klinisk-oversikt/2019/05/Krympt-por-syndrom--ett-nyupptackt-syndrom-med-hog-prevalens-och-mortalitet/
- date added to LUP
- 2019-07-10 09:43:13
- date last changed
- 2022-01-31 23:27:20
@article{88a1fd2d-250c-4736-8f4f-705d3377bd44, abstract = {{<p>Shrunken Pore Syndrome was defined in 2015 and is characterised by the glomerular filtration of 5-40 kDa molecules being selectively decreased compared to that of molecules <0.2 kDa, e.g. water and creatinine. The diagnose is based upon identification of a decreased eGFRcystatin C/eGFRcreatinine ratio, and ratios -< 0.6 or 0.7 have most often been used to identify the diagnose. The mortality is strongly increased in all investigated populations and increases progressively with a decrease in the eGFRcystatin C/eGFRcreatinine ratio used to identify the syndrome. The prevalence of the syndrome varies with the eGFRcystatin C/eGFRcreatinine ratio used for diagnosis, but when a ratio of 0.6 is used, the prevalence has varied between 2 and 8%. The pathophysiology might be the accumulation of atherosclerosis-promoting proteins occurring in patients with the syndrome. The syndrome might explain the superiority of eGFRcystatin C over eGFRcreatinine in identifying high-risk kidney patients.</p>}}, author = {{Grubb, Anders}}, issn = {{0023-7205}}, language = {{swe}}, month = {{05}}, publisher = {{Swedish Medical Association}}, series = {{Läkartidningen}}, title = {{Krympt por-syndrom – ett nyupptäckt syndrom med hög prevalens och mortalitet}}, url = {{http://lakartidningen.se/Klinik-och-vetenskap/Klinisk-oversikt/2019/05/Krympt-por-syndrom--ett-nyupptackt-syndrom-med-hog-prevalens-och-mortalitet/}}, volume = {{116}}, year = {{2019}}, }