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Krympt por-syndrom – ett nyupptäckt syndrom med hög prevalens och mortalitet

Grubb, Anders LU (2019) In Lakartidningen 116.
Abstract

Shrunken Pore Syndrome was defined in 2015 and is characterised by the glomerular filtration of 5-40 kDa molecules being selectively decreased compared to that of molecules <0.2 kDa, e.g. water and creatinine. The diagnose is based upon identification of a decreased eGFRcystatin C/eGFRcreatinine ratio, and ratios -< 0.6 or 0.7 have most often been used to identify the diagnose. The mortality is strongly increased in all investigated populations and increases progressively with a decrease in the eGFRcystatin C/eGFRcreatinine ratio used to identify the syndrome. The prevalence of the syndrome varies with the eGFRcystatin C/eGFRcreatinine ratio used for diagnosis, but when a ratio of 0.6 is used, the prevalence has varied between 2... (More)

Shrunken Pore Syndrome was defined in 2015 and is characterised by the glomerular filtration of 5-40 kDa molecules being selectively decreased compared to that of molecules <0.2 kDa, e.g. water and creatinine. The diagnose is based upon identification of a decreased eGFRcystatin C/eGFRcreatinine ratio, and ratios -< 0.6 or 0.7 have most often been used to identify the diagnose. The mortality is strongly increased in all investigated populations and increases progressively with a decrease in the eGFRcystatin C/eGFRcreatinine ratio used to identify the syndrome. The prevalence of the syndrome varies with the eGFRcystatin C/eGFRcreatinine ratio used for diagnosis, but when a ratio of 0.6 is used, the prevalence has varied between 2 and 8%. The pathophysiology might be the accumulation of atherosclerosis-promoting proteins occurring in patients with the syndrome. The syndrome might explain the superiority of eGFRcystatin C over eGFRcreatinine in identifying high-risk kidney patients.

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author
organization
alternative title
Shrunken Pore Syndrome - a new syndrome
publishing date
type
Contribution to journal
publication status
published
subject
in
Lakartidningen
volume
116
publisher
Swedish Medical Association
external identifiers
  • scopus:85068169334
  • pmid:31192397
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
88a1fd2d-250c-4736-8f4f-705d3377bd44
alternative location
http://lakartidningen.se/Klinik-och-vetenskap/Klinisk-oversikt/2019/05/Krympt-por-syndrom--ett-nyupptackt-syndrom-med-hog-prevalens-och-mortalitet/
date added to LUP
2019-07-10 09:43:13
date last changed
2019-08-06 03:24:00
@article{88a1fd2d-250c-4736-8f4f-705d3377bd44,
  abstract     = {<p>Shrunken Pore Syndrome was defined in 2015 and is characterised by the glomerular filtration of 5-40 kDa molecules being selectively decreased compared to that of molecules &lt;0.2 kDa, e.g. water and creatinine. The diagnose is based upon identification of a decreased eGFRcystatin C/eGFRcreatinine ratio, and ratios -&lt; 0.6 or 0.7 have most often been used to identify the diagnose. The mortality is strongly increased in all investigated populations and increases progressively with a decrease in the eGFRcystatin C/eGFRcreatinine ratio used to identify the syndrome. The prevalence of the syndrome varies with the eGFRcystatin C/eGFRcreatinine ratio used for diagnosis, but when a ratio of 0.6 is used, the prevalence has varied between 2 and 8%. The pathophysiology might be the accumulation of atherosclerosis-promoting proteins occurring in patients with the syndrome. The syndrome might explain the superiority of eGFRcystatin C over eGFRcreatinine in identifying high-risk kidney patients.</p>},
  author       = {Grubb, Anders},
  issn         = {0023-7205},
  language     = {swe},
  month        = {05},
  publisher    = {Swedish Medical Association},
  series       = {Lakartidningen},
  title        = {Krympt por-syndrom – ett nyupptäckt syndrom med hög prevalens och mortalitet},
  url          = {http://lakartidningen.se/Klinik-och-vetenskap/Klinisk-oversikt/2019/05/Krympt-por-syndrom--ett-nyupptackt-syndrom-med-hog-prevalens-och-mortalitet/},
  volume       = {116},
  year         = {2019},
}