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Dynamics of the development of multiple follicles by early versus late hCG administration in ART program

Falagario, Maddalena LU orcid ; Trerotoli, Paolo ; Chincoli, Annarosa ; Cobuzzi, Isabella ; Vacca, Margherita P ; Falagario, Doriana ; Nardelli, Claudia and Depalo, Raffaella (2017) In Gynecological Endocrinology 33(2). p.105-108
Abstract

OBJECTIVE: To evaluate, in patients stimulated with recombinant FSH and GnRH antagonists, whether triggering the final maturation of oocytes affects IVF outcomes.

STUDY DESIGN: Five hundred and six IVF procedures were divided into three groups according to the timing of hCG administration: when at least 2 follicles reached the diameter of 17 mm, at least 2 follicles reached 18 mm and at least 2 follicles reached 20 mm. The main outcome was the number of mature oocyte that was the dependent variable of a multivariate model whose independents were, age, AFC, hCG timing, E2 levels at hCG day, number of follicles in different categories of dimension. Secondary endpoints were to compare fertilization, implantation and pregnancy rates... (More)

OBJECTIVE: To evaluate, in patients stimulated with recombinant FSH and GnRH antagonists, whether triggering the final maturation of oocytes affects IVF outcomes.

STUDY DESIGN: Five hundred and six IVF procedures were divided into three groups according to the timing of hCG administration: when at least 2 follicles reached the diameter of 17 mm, at least 2 follicles reached 18 mm and at least 2 follicles reached 20 mm. The main outcome was the number of mature oocyte that was the dependent variable of a multivariate model whose independents were, age, AFC, hCG timing, E2 levels at hCG day, number of follicles in different categories of dimension. Secondary endpoints were to compare fertilization, implantation and pregnancy rates in a multilevel multivariate model whose covariates were age, BMI, AFC, embryo quality and cause of infertility.

RESULTS: Timing did not result a statistically significant factor influencing the number of oocytes collected, which was influenced by age, AFC, number of follicles between 12.1 and 15.9 mm and E2 levels. Implantation rate and pregnancy rate appear to be affected only by embryo quality.

CONCLUSION: The number of oocytes collected and the probability of pregnancy are not associated with the time of hCG administration.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Chorionic Gonadotropin/administration & dosage, Female, Fertilization in Vitro/methods, Humans, Oocytes/physiology, Outcome Assessment (Health Care), Pregnancy, Pregnancy Rate, Reproductive Control Agents/administration & dosage, Time Factors
in
Gynecological Endocrinology
volume
33
issue
2
pages
105 - 108
publisher
Informa Healthcare
external identifiers
  • pmid:27808664
  • scopus:84994099200
ISSN
0951-3590
DOI
10.1080/09513590.2016.1239252
language
English
LU publication?
no
id
88a5d69b-f576-4778-9412-18febdfe8a43
date added to LUP
2019-02-14 10:07:38
date last changed
2024-06-11 05:15:21
@article{88a5d69b-f576-4778-9412-18febdfe8a43,
  abstract     = {{<p>OBJECTIVE: To evaluate, in patients stimulated with recombinant FSH and GnRH antagonists, whether triggering the final maturation of oocytes affects IVF outcomes.</p><p>STUDY DESIGN: Five hundred and six IVF procedures were divided into three groups according to the timing of hCG administration: when at least 2 follicles reached the diameter of 17 mm, at least 2 follicles reached 18 mm and at least 2 follicles reached 20 mm. The main outcome was the number of mature oocyte that was the dependent variable of a multivariate model whose independents were, age, AFC, hCG timing, E2 levels at hCG day, number of follicles in different categories of dimension. Secondary endpoints were to compare fertilization, implantation and pregnancy rates in a multilevel multivariate model whose covariates were age, BMI, AFC, embryo quality and cause of infertility.</p><p>RESULTS: Timing did not result a statistically significant factor influencing the number of oocytes collected, which was influenced by age, AFC, number of follicles between 12.1 and 15.9 mm and E2 levels. Implantation rate and pregnancy rate appear to be affected only by embryo quality.</p><p>CONCLUSION: The number of oocytes collected and the probability of pregnancy are not associated with the time of hCG administration.</p>}},
  author       = {{Falagario, Maddalena and Trerotoli, Paolo and Chincoli, Annarosa and Cobuzzi, Isabella and Vacca, Margherita P and Falagario, Doriana and Nardelli, Claudia and Depalo, Raffaella}},
  issn         = {{0951-3590}},
  keywords     = {{Adult; Chorionic Gonadotropin/administration & dosage; Female; Fertilization in Vitro/methods; Humans; Oocytes/physiology; Outcome Assessment (Health Care); Pregnancy; Pregnancy Rate; Reproductive Control Agents/administration & dosage; Time Factors}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{105--108}},
  publisher    = {{Informa Healthcare}},
  series       = {{Gynecological Endocrinology}},
  title        = {{Dynamics of the development of multiple follicles by early versus late hCG administration in ART program}},
  url          = {{http://dx.doi.org/10.1080/09513590.2016.1239252}},
  doi          = {{10.1080/09513590.2016.1239252}},
  volume       = {{33}},
  year         = {{2017}},
}