Severe insulin-resistant diabetes due to insulin antibodies associated with eosinophilia
(2015) In Internal Medicine 54(18). p.2367-2371- Abstract
A 66-year-old man with type 2 diabetes on hemodialysis treatment was admitted due to poor glycemic control. His serum insulin level and the 125I-insulin binding rate were extremely high with an increased eosinophil count, although he did not have an allergic reaction to insulin or an elevation of specific IgE for human insulin. A Scatchard analysis revealed that the patient’s insulin antibodies had a low affinity constant and a high binding capacity. Prednisolone administration decreased the eosinophil count and 125I-insulin binding rate; accordingly, the glycemic control improved. Corticosteroid therapy may be a potent therapeutic strategy for insulin antibody-induced severe insulin resistance with... (More)
A 66-year-old man with type 2 diabetes on hemodialysis treatment was admitted due to poor glycemic control. His serum insulin level and the 125I-insulin binding rate were extremely high with an increased eosinophil count, although he did not have an allergic reaction to insulin or an elevation of specific IgE for human insulin. A Scatchard analysis revealed that the patient’s insulin antibodies had a low affinity constant and a high binding capacity. Prednisolone administration decreased the eosinophil count and 125I-insulin binding rate; accordingly, the glycemic control improved. Corticosteroid therapy may be a potent therapeutic strategy for insulin antibody-induced severe insulin resistance with eosinophilia.
(Less)
- author
- Takaya, Makiyo ; Nagao, Mototsugu LU ; Takemitsu, Shuji ; Nakajima, Yasushi ; Sugihara, Hitoshi ; Uchigata, Yasuko and Oikawa, Shinichi
- publishing date
- 2015-09-15
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Corticosteroids, Eosinophilia, Insulin antibodies
- in
- Internal Medicine
- volume
- 54
- issue
- 18
- pages
- 2367 - 2371
- publisher
- Japanese Society of Internal Medicine
- external identifiers
-
- scopus:84941557416
- ISSN
- 0918-2918
- DOI
- 10.2169/internalmedicine.54.4022
- language
- English
- LU publication?
- no
- id
- 88d04f91-cb06-4ccb-9d87-b497c1e025fb
- date added to LUP
- 2017-08-23 20:01:07
- date last changed
- 2022-01-30 22:14:55
@article{88d04f91-cb06-4ccb-9d87-b497c1e025fb, abstract = {{<p>A 66-year-old man with type 2 diabetes on hemodialysis treatment was admitted due to poor glycemic control. His serum insulin level and the <sup>125</sup>I-insulin binding rate were extremely high with an increased eosinophil count, although he did not have an allergic reaction to insulin or an elevation of specific IgE for human insulin. A Scatchard analysis revealed that the patient’s insulin antibodies had a low affinity constant and a high binding capacity. Prednisolone administration decreased the eosinophil count and <sup>125</sup>I-insulin binding rate; accordingly, the glycemic control improved. Corticosteroid therapy may be a potent therapeutic strategy for insulin antibody-induced severe insulin resistance with eosinophilia.</p>}}, author = {{Takaya, Makiyo and Nagao, Mototsugu and Takemitsu, Shuji and Nakajima, Yasushi and Sugihara, Hitoshi and Uchigata, Yasuko and Oikawa, Shinichi}}, issn = {{0918-2918}}, keywords = {{Corticosteroids; Eosinophilia; Insulin antibodies}}, language = {{eng}}, month = {{09}}, number = {{18}}, pages = {{2367--2371}}, publisher = {{Japanese Society of Internal Medicine}}, series = {{Internal Medicine}}, title = {{Severe insulin-resistant diabetes due to insulin antibodies associated with eosinophilia}}, url = {{http://dx.doi.org/10.2169/internalmedicine.54.4022}}, doi = {{10.2169/internalmedicine.54.4022}}, volume = {{54}}, year = {{2015}}, }