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Severe insulin-resistant diabetes due to insulin antibodies associated with eosinophilia

Takaya, Makiyo ; Nagao, Mototsugu LU ; Takemitsu, Shuji ; Nakajima, Yasushi ; Sugihara, Hitoshi ; Uchigata, Yasuko and Oikawa, Shinichi (2015) In Internal Medicine 54(18). p.2367-2371
Abstract

A 66-year-old man with type 2 diabetes on hemodialysis treatment was admitted due to poor glycemic control. His serum insulin level and the 125I-insulin binding rate were extremely high with an increased eosinophil count, although he did not have an allergic reaction to insulin or an elevation of specific IgE for human insulin. A Scatchard analysis revealed that the patient’s insulin antibodies had a low affinity constant and a high binding capacity. Prednisolone administration decreased the eosinophil count and 125I-insulin binding rate; accordingly, the glycemic control improved. Corticosteroid therapy may be a potent therapeutic strategy for insulin antibody-induced severe insulin resistance with... (More)

A 66-year-old man with type 2 diabetes on hemodialysis treatment was admitted due to poor glycemic control. His serum insulin level and the 125I-insulin binding rate were extremely high with an increased eosinophil count, although he did not have an allergic reaction to insulin or an elevation of specific IgE for human insulin. A Scatchard analysis revealed that the patient’s insulin antibodies had a low affinity constant and a high binding capacity. Prednisolone administration decreased the eosinophil count and 125I-insulin binding rate; accordingly, the glycemic control improved. Corticosteroid therapy may be a potent therapeutic strategy for insulin antibody-induced severe insulin resistance with eosinophilia.

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Please use this url to cite or link to this publication:
author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Corticosteroids, Eosinophilia, Insulin antibodies
in
Internal Medicine
volume
54
issue
18
pages
2367 - 2371
publisher
Japanese Society of Internal Medicine
external identifiers
  • scopus:84941557416
ISSN
0918-2918
DOI
10.2169/internalmedicine.54.4022
language
English
LU publication?
no
id
88d04f91-cb06-4ccb-9d87-b497c1e025fb
date added to LUP
2017-08-23 20:01:07
date last changed
2025-10-14 11:31:12
@article{88d04f91-cb06-4ccb-9d87-b497c1e025fb,
  abstract     = {{<p>A 66-year-old man with type 2 diabetes on hemodialysis treatment was admitted due to poor glycemic control. His serum insulin level and the <sup>125</sup>I-insulin binding rate were extremely high with an increased eosinophil count, although he did not have an allergic reaction to insulin or an elevation of specific IgE for human insulin. A Scatchard analysis revealed that the patient’s insulin antibodies had a low affinity constant and a high binding capacity. Prednisolone administration decreased the eosinophil count and <sup>125</sup>I-insulin binding rate; accordingly, the glycemic control improved. Corticosteroid therapy may be a potent therapeutic strategy for insulin antibody-induced severe insulin resistance with eosinophilia.</p>}},
  author       = {{Takaya, Makiyo and Nagao, Mototsugu and Takemitsu, Shuji and Nakajima, Yasushi and Sugihara, Hitoshi and Uchigata, Yasuko and Oikawa, Shinichi}},
  issn         = {{0918-2918}},
  keywords     = {{Corticosteroids; Eosinophilia; Insulin antibodies}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{18}},
  pages        = {{2367--2371}},
  publisher    = {{Japanese Society of Internal Medicine}},
  series       = {{Internal Medicine}},
  title        = {{Severe insulin-resistant diabetes due to insulin antibodies associated with eosinophilia}},
  url          = {{http://dx.doi.org/10.2169/internalmedicine.54.4022}},
  doi          = {{10.2169/internalmedicine.54.4022}},
  volume       = {{54}},
  year         = {{2015}},
}