Evaluation of two pairs of chiral stationary phases: Effects from the length of the achiral spacers
(2004) In Chirality 16(9). p.614-624- Abstract
- Two pairs of chiral stationary phases (CSPs) with different C-2-symmetric central parts were prepared and evaluated by chromatography of a series of structurally different racemates. Within each pair, the selectors on which the CSPs are based had different lengths of their achiral spacers. The CSPs based on selectors with short spacers showed higher enantioselectivity than the phases incorporating long spacers. On one pair of the phases, a study of the influence from different retention modifiers was performed for a series of benzodiazepinones. This demonstrated the importance of the polymer structure formed from the selectors with different spacer lengths for the enantiodiscriminating ability of the CSPs. (C) 2004 Wiley-Liss, Inc.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/139426
- author
- Thunberg, L ; Allenmark, S ; Friberg, Annika LU ; Ek, Fredrik LU and Frejd, Torbjörn LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- enantioselective liquid chromatography, racemate resolution, selector, synthesis, benzodiazepinones, multiple hydrogen bonding
- in
- Chirality
- volume
- 16
- issue
- 9
- pages
- 614 - 624
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000224693700007
- scopus:7044272686
- ISSN
- 1520-636X
- DOI
- 10.1002/chir.20080
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Chemical Biology and Drug Discovery (013210700)
- id
- 890cf220-ea0b-444e-b0f6-8f8fb0ddea15 (old id 139426)
- date added to LUP
- 2016-04-01 11:58:15
- date last changed
- 2022-03-28 18:23:03
@article{890cf220-ea0b-444e-b0f6-8f8fb0ddea15, abstract = {{Two pairs of chiral stationary phases (CSPs) with different C-2-symmetric central parts were prepared and evaluated by chromatography of a series of structurally different racemates. Within each pair, the selectors on which the CSPs are based had different lengths of their achiral spacers. The CSPs based on selectors with short spacers showed higher enantioselectivity than the phases incorporating long spacers. On one pair of the phases, a study of the influence from different retention modifiers was performed for a series of benzodiazepinones. This demonstrated the importance of the polymer structure formed from the selectors with different spacer lengths for the enantiodiscriminating ability of the CSPs. (C) 2004 Wiley-Liss, Inc.}}, author = {{Thunberg, L and Allenmark, S and Friberg, Annika and Ek, Fredrik and Frejd, Torbjörn}}, issn = {{1520-636X}}, keywords = {{enantioselective liquid chromatography; racemate resolution; selector; synthesis; benzodiazepinones; multiple hydrogen bonding}}, language = {{eng}}, number = {{9}}, pages = {{614--624}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Chirality}}, title = {{Evaluation of two pairs of chiral stationary phases: Effects from the length of the achiral spacers}}, url = {{http://dx.doi.org/10.1002/chir.20080}}, doi = {{10.1002/chir.20080}}, volume = {{16}}, year = {{2004}}, }