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Diabetes duration may modify the association between genetic variation in the glycoprotein la subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis

Reiner, AP ; Agardh, Elisabet LU ; Teramura, G ; Gaur, P ; Gaur, LK and Agardh, Carl-David LU (2003) In Thrombosis and Haemostasis 89(1). p.142-148
Abstract
Genetic factors appear to contribute to the severity and progression of diabetic retinopathy. We assessed the associations of the C807T and Glu505Lys variants of the glycoprotein Ia (alpha(2) integrin) subunit of the platelet/endothelial collagen receptor and risk of retinopathy in a population-based survey of 288 diabetic patients in one Swedish community. Neither variant was associated with retinopathy risk overall. However, the 807T variant was associated with increased risk of severe retinopathy, and the association was modified by diabetes duration. Among patients with diabetes of longer duration (greater than or equal to25 years), the 807T variant was strongly associated with risk of severe retinopathy (odds ratio 7.49, 95%... (More)
Genetic factors appear to contribute to the severity and progression of diabetic retinopathy. We assessed the associations of the C807T and Glu505Lys variants of the glycoprotein Ia (alpha(2) integrin) subunit of the platelet/endothelial collagen receptor and risk of retinopathy in a population-based survey of 288 diabetic patients in one Swedish community. Neither variant was associated with retinopathy risk overall. However, the 807T variant was associated with increased risk of severe retinopathy, and the association was modified by diabetes duration. Among patients with diabetes of longer duration (greater than or equal to25 years), the 807T variant was strongly associated with risk of severe retinopathy (odds ratio 7.49, 95% confidence interval 1.75 to 32.1). There was no association between the 807T variant and risk of severe retinopathy among patients with diabetes duration <25 years. The Lys505 variant of glycoprotein la was associated with an odds ratio for severe retinopathy of 1.88 (95% confidence interval 0.83, to 4.24). Overall, there was a significant interaction between glycoprotein la genotype and duration of diabetes on the risk of retinopathy (P-value for interaction = 0.019). These results suggest the hypothesis that genetic variation of platelet glycoprotein la may play a particularly important role during the advanced stages of. diabetic retinopathy. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glycoprotein la, type 2 diabetes, diabetic retinopathy, type I, platelet, diabetes
in
Thrombosis and Haemostasis
volume
89
issue
1
pages
142 - 148
publisher
Schattauer GmbH
external identifiers
  • pmid:12540964
  • wos:000180742200020
  • scopus:0037246894
ISSN
0340-6245
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit on Vascular Diabetic Complications (013241510)
id
a6742b81-9324-4a1c-a7cf-ed5de0e00434 (old id 891243)
alternative location
http://www.schattauer.de/index.php?id=842&no_cache=1&artikel=12054
date added to LUP
2016-04-01 16:50:21
date last changed
2021-02-17 01:17:28
@article{a6742b81-9324-4a1c-a7cf-ed5de0e00434,
  abstract     = {Genetic factors appear to contribute to the severity and progression of diabetic retinopathy. We assessed the associations of the C807T and Glu505Lys variants of the glycoprotein Ia (alpha(2) integrin) subunit of the platelet/endothelial collagen receptor and risk of retinopathy in a population-based survey of 288 diabetic patients in one Swedish community. Neither variant was associated with retinopathy risk overall. However, the 807T variant was associated with increased risk of severe retinopathy, and the association was modified by diabetes duration. Among patients with diabetes of longer duration (greater than or equal to25 years), the 807T variant was strongly associated with risk of severe retinopathy (odds ratio 7.49, 95% confidence interval 1.75 to 32.1). There was no association between the 807T variant and risk of severe retinopathy among patients with diabetes duration &lt;25 years. The Lys505 variant of glycoprotein la was associated with an odds ratio for severe retinopathy of 1.88 (95% confidence interval 0.83, to 4.24). Overall, there was a significant interaction between glycoprotein la genotype and duration of diabetes on the risk of retinopathy (P-value for interaction = 0.019). These results suggest the hypothesis that genetic variation of platelet glycoprotein la may play a particularly important role during the advanced stages of. diabetic retinopathy.},
  author       = {Reiner, AP and Agardh, Elisabet and Teramura, G and Gaur, P and Gaur, LK and Agardh, Carl-David},
  issn         = {0340-6245},
  language     = {eng},
  number       = {1},
  pages        = {142--148},
  publisher    = {Schattauer GmbH},
  series       = {Thrombosis and Haemostasis},
  title        = {Diabetes duration may modify the association between genetic variation in the glycoprotein la subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis},
  url          = {http://www.schattauer.de/index.php?id=842&no_cache=1&artikel=12054},
  volume       = {89},
  year         = {2003},
}