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Evidence of tendon microtears due to cyclical loading in an in vivo tendinopathy model

Nakama, L H; King, K B; Abrahamsson, Sven LU and Rempel, D M (2005) In Journal of Orthopaedic Research 23(5). p.1199-1205
Abstract
Tendon injuries at the epicondyle can occur in athletes and workers whose job functions involve repetitive, high force hand activities, but the early pathophysiologic changes of tendon are not well known. The purpose of this study was to evaluate early tendon structural changes, specifically the formation of microtears, caused by cyclical loading. The Flexor Digitorum Profundus (FDP) muscle of nine New Zealand White rabbits was stimulated to contract repetitively for 80 h of cumulative loading over 14 weeks. The contralateral limb served as a control, The tendon at the medial epicondyle insertion site was harvested, sectioned, and stained. Microtears were quantified, using image analysis software, in four regions of the tendon, two regions... (More)
Tendon injuries at the epicondyle can occur in athletes and workers whose job functions involve repetitive, high force hand activities, but the early pathophysiologic changes of tendon are not well known. The purpose of this study was to evaluate early tendon structural changes, specifically the formation of microtears, caused by cyclical loading. The Flexor Digitorum Profundus (FDP) muscle of nine New Zealand White rabbits was stimulated to contract repetitively for 80 h of cumulative loading over 14 weeks. The contralateral limb served as a control, The tendon at the medial epicondyle insertion site was harvested, sectioned, and stained. Microtears were quantified, using image analysis software, in four regions of the tendon, two regions along the enthesis and two distal to the enthesis. The tear density (loaded: 1329 +/- 546 tears/mm(2); unloaded: 932 474 tears/mm(2)) and mean tear size (loaded: 18.3 +/- 6.1 mu m(2); unloaded: 14.0 +/- 4.8 mu m(2)) were significantly greater in the loaded limb (p < 0.0001) across all regions compared to the unloaded contralateral limb. These early microstructural changes in a repetitively loaded tendon may initiate a degenerative process that leads to tendinosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
microtears, tendinopathy, tendon, overuse, epicondylitis
in
Journal of Orthopaedic Research
volume
23
issue
5
pages
1199 - 1205
publisher
John Wiley & Sons
external identifiers
  • pmid:16140201
  • wos:000232173600030
  • scopus:24344442851
ISSN
1554-527X
DOI
10.1016/j.orthres.2005.03.006
language
English
LU publication?
yes
id
e1a48cb7-e4d8-4a25-95ba-8a073a875891 (old id 891538)
date added to LUP
2008-01-16 15:24:55
date last changed
2017-08-06 03:42:13
@article{e1a48cb7-e4d8-4a25-95ba-8a073a875891,
  abstract     = {Tendon injuries at the epicondyle can occur in athletes and workers whose job functions involve repetitive, high force hand activities, but the early pathophysiologic changes of tendon are not well known. The purpose of this study was to evaluate early tendon structural changes, specifically the formation of microtears, caused by cyclical loading. The Flexor Digitorum Profundus (FDP) muscle of nine New Zealand White rabbits was stimulated to contract repetitively for 80 h of cumulative loading over 14 weeks. The contralateral limb served as a control, The tendon at the medial epicondyle insertion site was harvested, sectioned, and stained. Microtears were quantified, using image analysis software, in four regions of the tendon, two regions along the enthesis and two distal to the enthesis. The tear density (loaded: 1329 +/- 546 tears/mm(2); unloaded: 932 474 tears/mm(2)) and mean tear size (loaded: 18.3 +/- 6.1 mu m(2); unloaded: 14.0 +/- 4.8 mu m(2)) were significantly greater in the loaded limb (p &lt; 0.0001) across all regions compared to the unloaded contralateral limb. These early microstructural changes in a repetitively loaded tendon may initiate a degenerative process that leads to tendinosis.},
  author       = {Nakama, L H and King, K B and Abrahamsson, Sven and Rempel, D M},
  issn         = {1554-527X},
  keyword      = {microtears,tendinopathy,tendon,overuse,epicondylitis},
  language     = {eng},
  number       = {5},
  pages        = {1199--1205},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Orthopaedic Research},
  title        = {Evidence of tendon microtears due to cyclical loading in an in vivo tendinopathy model},
  url          = {http://dx.doi.org/10.1016/j.orthres.2005.03.006},
  volume       = {23},
  year         = {2005},
}