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European consensus for the diagnosis of MCI and mild dementia : Preparatory phase

Festari, Cristina ; Massa, Federico ; Cotta Ramusino, Matteo ; Gandolfo, Federica ; Nicolosi, Valentina ; Orini, Stefania ; Aarsland, Dag ; Agosta, Federica ; Babiloni, Claudio and Boada, Mercè , et al. (2022) In Alzheimer's and Dementia
Abstract

Introduction: Etiological diagnosis of neurocognitive disorders of middle-old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization. We report methodology and preliminary results. Methods: Using a Delphi consensus method supported by a systematic literature review, 22 delegates from 11 relevant scientific societies defined workflow assumptions. Results: We extracted diagnostic accuracy figures from literature on the use of biomarkers in the diagnosis of main forms of neurocognitive disorders. Supported by this evidence, panelists defined clinical setting (specialist... (More)

Introduction: Etiological diagnosis of neurocognitive disorders of middle-old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization. We report methodology and preliminary results. Methods: Using a Delphi consensus method supported by a systematic literature review, 22 delegates from 11 relevant scientific societies defined workflow assumptions. Results: We extracted diagnostic accuracy figures from literature on the use of biomarkers in the diagnosis of main forms of neurocognitive disorders. Supported by this evidence, panelists defined clinical setting (specialist outpatient service), application stage (MCI-mild dementia), and detailed pre-assessment screening (clinical-neuropsychological evaluations, brain imaging, and blood tests). Discussion: The Delphi consensus on these assumptions set the stage for the development of the first pan-European workflow for biomarkers’ use in the etiological diagnosis of middle-old age neurocognitive disorders at MCI-mild dementia stages. Highlights: Rational use of biomarkers in neurocognitive disorders lacks consensus in Europe. A consensus of experts will define a workflow for the rational use of biomarkers. The diagnostic workflow will be patient-centered and based on clinical presentation. The workflow will be updated as new evidence accrues.

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organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
consensus, Delphi procedure, etiological diagnosis, imaging, major neurocognitive disorder, MCI, mild dementia – biomarker, neurocognitive disorders
in
Alzheimer's and Dementia
publisher
Wiley
external identifiers
  • scopus:85139755547
  • pmid:36209379
ISSN
1552-5260
DOI
10.1002/alz.12798
language
English
LU publication?
yes
id
891a4b65-e365-4ac6-9a22-bd6f1074d132
date added to LUP
2023-01-23 11:42:03
date last changed
2023-03-23 18:16:09
@article{891a4b65-e365-4ac6-9a22-bd6f1074d132,
  abstract     = {{<p>Introduction: Etiological diagnosis of neurocognitive disorders of middle-old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization. We report methodology and preliminary results. Methods: Using a Delphi consensus method supported by a systematic literature review, 22 delegates from 11 relevant scientific societies defined workflow assumptions. Results: We extracted diagnostic accuracy figures from literature on the use of biomarkers in the diagnosis of main forms of neurocognitive disorders. Supported by this evidence, panelists defined clinical setting (specialist outpatient service), application stage (MCI-mild dementia), and detailed pre-assessment screening (clinical-neuropsychological evaluations, brain imaging, and blood tests). Discussion: The Delphi consensus on these assumptions set the stage for the development of the first pan-European workflow for biomarkers’ use in the etiological diagnosis of middle-old age neurocognitive disorders at MCI-mild dementia stages. Highlights: Rational use of biomarkers in neurocognitive disorders lacks consensus in Europe. A consensus of experts will define a workflow for the rational use of biomarkers. The diagnostic workflow will be patient-centered and based on clinical presentation. The workflow will be updated as new evidence accrues.</p>}},
  author       = {{Festari, Cristina and Massa, Federico and Cotta Ramusino, Matteo and Gandolfo, Federica and Nicolosi, Valentina and Orini, Stefania and Aarsland, Dag and Agosta, Federica and Babiloni, Claudio and Boada, Mercè and Borroni, Barbara and Cappa, Stefano and Dubois, Bruno and Frederiksen, Kristian S. and Froelich, Lutz and Garibotto, Valentina and Georges, Jean and Haliassos, Alexander and Hansson, Oskar and Jessen, Frank and Kamondi, Anita and Kessels, Roy P.C. and Morbelli, Silvia and O'Brien, John T. and Otto, Markus and Perret-Liaudet, Armand and Pizzini, Francesca B. and Ritchie, Craig W. and Scheltens, Philip and Vandenbulcke, Mathieu and Vanninen, Ritva and Verhey, Frans and Vernooij, Meike W. and Yousry, Tarek and Van Der Flier, Wiesje M. and Nobili, Flavio and Frisoni, Giovanni B.}},
  issn         = {{1552-5260}},
  keywords     = {{consensus; Delphi procedure; etiological diagnosis; imaging; major neurocognitive disorder; MCI; mild dementia – biomarker; neurocognitive disorders}},
  language     = {{eng}},
  month        = {{10}},
  publisher    = {{Wiley}},
  series       = {{Alzheimer's and Dementia}},
  title        = {{European consensus for the diagnosis of MCI and mild dementia : Preparatory phase}},
  url          = {{http://dx.doi.org/10.1002/alz.12798}},
  doi          = {{10.1002/alz.12798}},
  year         = {{2022}},
}