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Distinct expression of calnexin in major human salivary glands

Gassler, N; Bohn, Jörg LU ; Schnolzer, M; Scheuerer, J; Obermuller, N; Otto, HF and Autschbach, F (2003) In Histology and Histopathology 18(1). p.121-127
Abstract
Calnexin (Cnx) has been characterized as a membrane-bound protein that transiently interacts in a unique chaperone system with newly synthesized glycoproteins in order to allow the establishment of their proper tertiary and, in most cases, quarternary structures. The aim of the study was to identify and to locate the expression of Cnx in the three major salivary glands of humans by different methods. Strong expression of Cnx protein and mRNA were generally found in serous salivary secretory units. With regard to mucous secretory units, expression of Cnx was only detectable at a low level in mucous acinar cells of sublingual glands, but not of submandibular glands. Expression of Cnx was always preserved in the surface epithelium of... (More)
Calnexin (Cnx) has been characterized as a membrane-bound protein that transiently interacts in a unique chaperone system with newly synthesized glycoproteins in order to allow the establishment of their proper tertiary and, in most cases, quarternary structures. The aim of the study was to identify and to locate the expression of Cnx in the three major salivary glands of humans by different methods. Strong expression of Cnx protein and mRNA were generally found in serous salivary secretory units. With regard to mucous secretory units, expression of Cnx was only detectable at a low level in mucous acinar cells of sublingual glands, but not of submandibular glands. Expression of Cnx was always preserved in the surface epithelium of intralobar and interlobular duct segments. In addition, expression of Cnx was detected in sebaceous glands of parotid tissues, with a distribution pattern resembling that seen in sebaceous glands of the normal skin. In conclusion, production of saliva is associated with the expression of Cnx. Synthesis of molecules in mucous secretory units is not necessarily associated with a strong Cnx expression, whereas synthesis in serous secretory units apparently is. The tissue-specific Cnx expression is also paralleled by the observation that the secretions produced by the major salivary glands differ in their composition and amount. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
calnexin, salivary gland, human
in
Histology and Histopathology
volume
18
issue
1
pages
121 - 127
publisher
Histology and Histopathology
external identifiers
  • pmid:12507291
  • wos:000180340500014
  • scopus:12244256804
ISSN
1699-5848
language
English
LU publication?
yes
id
d8be20db-3ab7-4837-9b61-59250d728ad1 (old id 892107)
alternative location
http://www.hh.um.es/Abstracts/Vol_18/18_1/18_1_121.htm
date added to LUP
2008-01-11 13:57:49
date last changed
2017-01-01 06:49:25
@article{d8be20db-3ab7-4837-9b61-59250d728ad1,
  abstract     = {Calnexin (Cnx) has been characterized as a membrane-bound protein that transiently interacts in a unique chaperone system with newly synthesized glycoproteins in order to allow the establishment of their proper tertiary and, in most cases, quarternary structures. The aim of the study was to identify and to locate the expression of Cnx in the three major salivary glands of humans by different methods. Strong expression of Cnx protein and mRNA were generally found in serous salivary secretory units. With regard to mucous secretory units, expression of Cnx was only detectable at a low level in mucous acinar cells of sublingual glands, but not of submandibular glands. Expression of Cnx was always preserved in the surface epithelium of intralobar and interlobular duct segments. In addition, expression of Cnx was detected in sebaceous glands of parotid tissues, with a distribution pattern resembling that seen in sebaceous glands of the normal skin. In conclusion, production of saliva is associated with the expression of Cnx. Synthesis of molecules in mucous secretory units is not necessarily associated with a strong Cnx expression, whereas synthesis in serous secretory units apparently is. The tissue-specific Cnx expression is also paralleled by the observation that the secretions produced by the major salivary glands differ in their composition and amount.},
  author       = {Gassler, N and Bohn, Jörg and Schnolzer, M and Scheuerer, J and Obermuller, N and Otto, HF and Autschbach, F},
  issn         = {1699-5848},
  keyword      = {calnexin,salivary gland,human},
  language     = {eng},
  number       = {1},
  pages        = {121--127},
  publisher    = {Histology and Histopathology},
  series       = {Histology and Histopathology},
  title        = {Distinct expression of calnexin in major human salivary glands},
  volume       = {18},
  year         = {2003},
}