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Immune development differs between preterm newborns fed mothers’ own milk and donor milk

Tan, Ziyang ; Zhong, Wen ; Danielsson, Hanna ; Arzoomand, Aron ; Lakshmikanth, Tadepally ; Chen, Qi ; Mikes, Jaromir ; Wang, Jun ; Chen, Yang and James, Anna , et al. (2025) In iScience 28(7).
Abstract

Extremely preterm infants are at risk of immune-mediated complications such as infections and inflammatory conditions like bronchopulmonary dysplasia and necrotizing enterocolitis. Preterm infants are immunologically distinct from term infants at birth, but subsequently undergo adaptive postnatal changes resulting in immunological convergence during their first 3 months. Here, we performed a systems-level analysis of immune development in 72 preterm infants born as early as 22 weeks to investigate factors associated with variation. We find similar immune trajectories during early postnatal immune development but occurring more slowly in infants born at 22–24 weeks. Immune development showed a greater resemblance to that of term-born... (More)

Extremely preterm infants are at risk of immune-mediated complications such as infections and inflammatory conditions like bronchopulmonary dysplasia and necrotizing enterocolitis. Preterm infants are immunologically distinct from term infants at birth, but subsequently undergo adaptive postnatal changes resulting in immunological convergence during their first 3 months. Here, we performed a systems-level analysis of immune development in 72 preterm infants born as early as 22 weeks to investigate factors associated with variation. We find similar immune trajectories during early postnatal immune development but occurring more slowly in infants born at 22–24 weeks. Immune development showed a greater resemblance to that of term-born children in preterm infants fed mother's own milk compared to donor milk. This developmental normalization was manifested by NK cell development and was not explained by differences in microbial colonization between feeding groups, possibly suggesting direct effects of bioactive milk molecules on developing immune cells in extremely preterm infants.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Female reproductive endocrinology, Immunology
in
iScience
volume
28
issue
7
article number
112918
publisher
Elsevier
external identifiers
  • pmid:40672699
  • scopus:105009071673
ISSN
2589-0042
DOI
10.1016/j.isci.2025.112918
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 The Authors
id
89236da2-3931-4c74-9b51-d522051b19e1
date added to LUP
2025-12-08 13:48:21
date last changed
2025-12-09 03:00:02
@article{89236da2-3931-4c74-9b51-d522051b19e1,
  abstract     = {{<p>Extremely preterm infants are at risk of immune-mediated complications such as infections and inflammatory conditions like bronchopulmonary dysplasia and necrotizing enterocolitis. Preterm infants are immunologically distinct from term infants at birth, but subsequently undergo adaptive postnatal changes resulting in immunological convergence during their first 3 months. Here, we performed a systems-level analysis of immune development in 72 preterm infants born as early as 22 weeks to investigate factors associated with variation. We find similar immune trajectories during early postnatal immune development but occurring more slowly in infants born at 22–24 weeks. Immune development showed a greater resemblance to that of term-born children in preterm infants fed mother's own milk compared to donor milk. This developmental normalization was manifested by NK cell development and was not explained by differences in microbial colonization between feeding groups, possibly suggesting direct effects of bioactive milk molecules on developing immune cells in extremely preterm infants.</p>}},
  author       = {{Tan, Ziyang and Zhong, Wen and Danielsson, Hanna and Arzoomand, Aron and Lakshmikanth, Tadepally and Chen, Qi and Mikes, Jaromir and Wang, Jun and Chen, Yang and James, Anna and Nilsson, Anders K. and Elfvin, Anders and Brusselaers, Nele and Portlock, Theo and Lundgren, Pia and Sävman, Karin and Wackernagel, Dirk and Hansen-Pupp, Ingrid and Ley, David and Uhlén, Mathias and Hellström, Ann and Brodin, Petter}},
  issn         = {{2589-0042}},
  keywords     = {{Female reproductive endocrinology; Immunology}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  publisher    = {{Elsevier}},
  series       = {{iScience}},
  title        = {{Immune development differs between preterm newborns fed mothers’ own milk and donor milk}},
  url          = {{http://dx.doi.org/10.1016/j.isci.2025.112918}},
  doi          = {{10.1016/j.isci.2025.112918}},
  volume       = {{28}},
  year         = {{2025}},
}