Further important sensitizers in patients sensitive to fragrances - I. Reactivity to 14 frequently used chemicals
(2002) In Contact Dermatitis 47(2). p.78-85- Abstract
- The aim of this study was to determine the frequency of responses to selected fragrance materials in consecutive patients patch tested in 6 dermatological centres in Europe. 1855 patients were evaluated with the 8% fragrance mix (FM) and 14 other frequently used well-defined fragrance chemicals (series 1). Each patient was classified regarding a history of adverse reactions to fragrances: certain, probable, questionable, none. Reactions to FM occurred in 11.3% of the subjects. The 6 substances with the highest reactivity following FM were Lyral(R) (2.7%), citral (1.1%), farnesol P (0.5%), citronellol (0.4%), hexyl cinnamic aldehyde (0.3%), and coumarin (0.3%). 41 (2.2%) of the patients reacted only to materials of series I and not to FM.... (More)
- The aim of this study was to determine the frequency of responses to selected fragrance materials in consecutive patients patch tested in 6 dermatological centres in Europe. 1855 patients were evaluated with the 8% fragrance mix (FM) and 14 other frequently used well-defined fragrance chemicals (series 1). Each patient was classified regarding a history of adverse reactions to fragrances: certain, probable, questionable, none. Reactions to FM occurred in 11.3% of the subjects. The 6 substances with the highest reactivity following FM were Lyral(R) (2.7%), citral (1.1%), farnesol P (0.5%), citronellol (0.4%), hexyl cinnamic aldehyde (0.3%), and coumarin (0.3%). 41 (2.2%) of the patients reacted only to materials of series I and not to FM. 6.6% of 1855 patients gave a history of adverse reactions to fragrances which was classified as certain. This group reacted to FM only in 41.1%, to series I and FM in 12.0% and to series I only in 7.2%. 74.3% of the 39 patients reacting to both FM and I of the materials of series I had any type of positive fragrance history, which was significantly higher in comparison to those with isolated reactions to series 1 (53.6% of 41), p = 0.04. The study identified further sensitizers relevant for patch testing of patients with contact dermatitis, of which Lyral(R) is the most important single chemical. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/892484
- author
- Frosch, PJ ; Johansen, JD ; Menne, T ; Pirker, C ; Rastogi, SC ; Andersen, KE ; Bruze, Magnus LU ; Goossens, A ; Lepoittevin, JP and White, IR
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- fragrance mix, fragrances, history of fragrance, sensitivity, patch testing, Lyral (R), contact allergy
- in
- Contact Dermatitis
- volume
- 47
- issue
- 2
- pages
- 78 - 85
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000179138600004
- pmid:12423404
- scopus:0036877371
- ISSN
- 0105-1873
- DOI
- 10.1034/j.1600-0536.2002.470204.x
- language
- English
- LU publication?
- yes
- id
- 7060fa63-d2d5-472c-8cbd-7e804c13574a (old id 892484)
- date added to LUP
- 2016-04-01 12:27:47
- date last changed
- 2022-08-13 23:56:18
@article{7060fa63-d2d5-472c-8cbd-7e804c13574a,
abstract = {{The aim of this study was to determine the frequency of responses to selected fragrance materials in consecutive patients patch tested in 6 dermatological centres in Europe. 1855 patients were evaluated with the 8% fragrance mix (FM) and 14 other frequently used well-defined fragrance chemicals (series 1). Each patient was classified regarding a history of adverse reactions to fragrances: certain, probable, questionable, none. Reactions to FM occurred in 11.3% of the subjects. The 6 substances with the highest reactivity following FM were Lyral(R) (2.7%), citral (1.1%), farnesol P (0.5%), citronellol (0.4%), hexyl cinnamic aldehyde (0.3%), and coumarin (0.3%). 41 (2.2%) of the patients reacted only to materials of series I and not to FM. 6.6% of 1855 patients gave a history of adverse reactions to fragrances which was classified as certain. This group reacted to FM only in 41.1%, to series I and FM in 12.0% and to series I only in 7.2%. 74.3% of the 39 patients reacting to both FM and I of the materials of series I had any type of positive fragrance history, which was significantly higher in comparison to those with isolated reactions to series 1 (53.6% of 41), p = 0.04. The study identified further sensitizers relevant for patch testing of patients with contact dermatitis, of which Lyral(R) is the most important single chemical.}},
author = {{Frosch, PJ and Johansen, JD and Menne, T and Pirker, C and Rastogi, SC and Andersen, KE and Bruze, Magnus and Goossens, A and Lepoittevin, JP and White, IR}},
issn = {{0105-1873}},
keywords = {{fragrance mix; fragrances; history of fragrance; sensitivity; patch testing; Lyral (R); contact allergy}},
language = {{eng}},
number = {{2}},
pages = {{78--85}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{Further important sensitizers in patients sensitive to fragrances - I. Reactivity to 14 frequently used chemicals}},
url = {{http://dx.doi.org/10.1034/j.1600-0536.2002.470204.x}},
doi = {{10.1034/j.1600-0536.2002.470204.x}},
volume = {{47}},
year = {{2002}},
}