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Further important sensitizers in patients sensitive to fragrances - I. Reactivity to 14 frequently used chemicals

Frosch, PJ; Johansen, JD; Menne, T; Pirker, C; Rastogi, SC; Andersen, KE; Bruze, Magnus LU ; Goossens, A; Lepoittevin, JP and White, IR (2002) In Contact Dermatitis 47(2). p.78-85
Abstract
The aim of this study was to determine the frequency of responses to selected fragrance materials in consecutive patients patch tested in 6 dermatological centres in Europe. 1855 patients were evaluated with the 8% fragrance mix (FM) and 14 other frequently used well-defined fragrance chemicals (series 1). Each patient was classified regarding a history of adverse reactions to fragrances: certain, probable, questionable, none. Reactions to FM occurred in 11.3% of the subjects. The 6 substances with the highest reactivity following FM were Lyral(R) (2.7%), citral (1.1%), farnesol P (0.5%), citronellol (0.4%), hexyl cinnamic aldehyde (0.3%), and coumarin (0.3%). 41 (2.2%) of the patients reacted only to materials of series I and not to FM.... (More)
The aim of this study was to determine the frequency of responses to selected fragrance materials in consecutive patients patch tested in 6 dermatological centres in Europe. 1855 patients were evaluated with the 8% fragrance mix (FM) and 14 other frequently used well-defined fragrance chemicals (series 1). Each patient was classified regarding a history of adverse reactions to fragrances: certain, probable, questionable, none. Reactions to FM occurred in 11.3% of the subjects. The 6 substances with the highest reactivity following FM were Lyral(R) (2.7%), citral (1.1%), farnesol P (0.5%), citronellol (0.4%), hexyl cinnamic aldehyde (0.3%), and coumarin (0.3%). 41 (2.2%) of the patients reacted only to materials of series I and not to FM. 6.6% of 1855 patients gave a history of adverse reactions to fragrances which was classified as certain. This group reacted to FM only in 41.1%, to series I and FM in 12.0% and to series I only in 7.2%. 74.3% of the 39 patients reacting to both FM and I of the materials of series I had any type of positive fragrance history, which was significantly higher in comparison to those with isolated reactions to series 1 (53.6% of 41), p = 0.04. The study identified further sensitizers relevant for patch testing of patients with contact dermatitis, of which Lyral(R) is the most important single chemical. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
fragrance mix, fragrances, history of fragrance, sensitivity, patch testing, Lyral (R), contact allergy
in
Contact Dermatitis
volume
47
issue
2
pages
78 - 85
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000179138600004
  • pmid:12423404
  • scopus:0036877371
ISSN
0105-1873
DOI
10.1034/j.1600-0536.2002.470204.x
language
English
LU publication?
yes
id
7060fa63-d2d5-472c-8cbd-7e804c13574a (old id 892484)
date added to LUP
2008-01-22 08:46:26
date last changed
2017-12-10 03:53:44
@article{7060fa63-d2d5-472c-8cbd-7e804c13574a,
  abstract     = {The aim of this study was to determine the frequency of responses to selected fragrance materials in consecutive patients patch tested in 6 dermatological centres in Europe. 1855 patients were evaluated with the 8% fragrance mix (FM) and 14 other frequently used well-defined fragrance chemicals (series 1). Each patient was classified regarding a history of adverse reactions to fragrances: certain, probable, questionable, none. Reactions to FM occurred in 11.3% of the subjects. The 6 substances with the highest reactivity following FM were Lyral(R) (2.7%), citral (1.1%), farnesol P (0.5%), citronellol (0.4%), hexyl cinnamic aldehyde (0.3%), and coumarin (0.3%). 41 (2.2%) of the patients reacted only to materials of series I and not to FM. 6.6% of 1855 patients gave a history of adverse reactions to fragrances which was classified as certain. This group reacted to FM only in 41.1%, to series I and FM in 12.0% and to series I only in 7.2%. 74.3% of the 39 patients reacting to both FM and I of the materials of series I had any type of positive fragrance history, which was significantly higher in comparison to those with isolated reactions to series 1 (53.6% of 41), p = 0.04. The study identified further sensitizers relevant for patch testing of patients with contact dermatitis, of which Lyral(R) is the most important single chemical.},
  author       = {Frosch, PJ and Johansen, JD and Menne, T and Pirker, C and Rastogi, SC and Andersen, KE and Bruze, Magnus and Goossens, A and Lepoittevin, JP and White, IR},
  issn         = {0105-1873},
  keyword      = {fragrance mix,fragrances,history of fragrance,sensitivity,patch testing,Lyral (R),contact allergy},
  language     = {eng},
  number       = {2},
  pages        = {78--85},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Further important sensitizers in patients sensitive to fragrances - I. Reactivity to 14 frequently used chemicals},
  url          = {http://dx.doi.org/10.1034/j.1600-0536.2002.470204.x},
  volume       = {47},
  year         = {2002},
}