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Does nociceptin play a role in pain disorders in man?

Mork, H; Hommel, K; Uddman, Rolf LU ; Edvinsson, L and Jensen, R (2002) In Peptides 23(9). p.1581-1587
Abstract
Nociceptin-immunoreactive cellbodies were detected in the human trigeminal ganglion, while no such fibers were identified in the temporal artery or in dermal tissue from the neck region. In four healthy subjects receiving nociceptin into the temporal muscle in an open labeled design no pain was detected. In 10 healthy subjects who received 200 pmol of nociceptin into tender non-dominant trapezius muscles in a placebo-controlled, randomized, balanced, and double-blinded design local tenderness increased (P = 0.025) while no pain was noted. Thus, the action of nociceptin should be searched for in the trigeminal ganglion and/or in the central nervous system (CNS). (C) 2002 Elsevier Science Inc. All rights reserved.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
myofascial pain, myofascial tenderness, intra-muscular, human, injection, nociceptin
in
Peptides
volume
23
issue
9
pages
1581 - 1587
publisher
Elsevier
external identifiers
  • wos:000178339300007
  • pmid:12217418
  • scopus:0036710535
ISSN
1873-5169
DOI
10.1016/S0196-9781(02)00101-8
language
English
LU publication?
yes
id
5e5996e2-8aec-432e-b5b2-c16130a13fa0 (old id 892603)
date added to LUP
2008-01-23 21:52:47
date last changed
2017-07-30 03:52:38
@article{5e5996e2-8aec-432e-b5b2-c16130a13fa0,
  abstract     = {Nociceptin-immunoreactive cellbodies were detected in the human trigeminal ganglion, while no such fibers were identified in the temporal artery or in dermal tissue from the neck region. In four healthy subjects receiving nociceptin into the temporal muscle in an open labeled design no pain was detected. In 10 healthy subjects who received 200 pmol of nociceptin into tender non-dominant trapezius muscles in a placebo-controlled, randomized, balanced, and double-blinded design local tenderness increased (P = 0.025) while no pain was noted. Thus, the action of nociceptin should be searched for in the trigeminal ganglion and/or in the central nervous system (CNS). (C) 2002 Elsevier Science Inc. All rights reserved.},
  author       = {Mork, H and Hommel, K and Uddman, Rolf and Edvinsson, L and Jensen, R},
  issn         = {1873-5169},
  keyword      = {myofascial pain,myofascial tenderness,intra-muscular,human,injection,nociceptin},
  language     = {eng},
  number       = {9},
  pages        = {1581--1587},
  publisher    = {Elsevier},
  series       = {Peptides},
  title        = {Does nociceptin play a role in pain disorders in man?},
  url          = {http://dx.doi.org/10.1016/S0196-9781(02)00101-8},
  volume       = {23},
  year         = {2002},
}