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Monitoring levels of preservative sensitivity in Europe - A 10-year overview (1991-2000)

Wilkinson, JD; Shaw, S; Andersen, KE; Brandao, FM; Bruynzeel, DP; Bruze, Magnus LU ; Camarasa, JMG; Diepgen, TL; Ducombs, G and Frosch, PJ, et al. (2002) In Contact Dermatitis 46(4). p.207-210
Abstract
A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.
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publication status
published
subject
keywords
diazolidinyl urea, formaldehyde, imidazolidinyl urea, methyldibromoglutaronitrile, patch test sensitization, parabens, preservatives, quaternium-15, 5-chloro-2-methyl-4-isothiazolin-3-one+2-methyl-4-isothiazolin-3-one
in
Contact Dermatitis
volume
46
issue
4
pages
207 - 210
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000176797000004
  • pmid:12081698
  • scopus:0036318486
ISSN
0105-1873
DOI
10.1034/j.1600-0536.2002.460404.x
language
English
LU publication?
yes
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086c5ca1-f4db-4514-8663-0a70d958eac2 (old id 892992)
date added to LUP
2008-01-23 11:30:05
date last changed
2017-12-10 03:51:44
@article{086c5ca1-f4db-4514-8663-0a70d958eac2,
  abstract     = {A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.},
  author       = {Wilkinson, JD and Shaw, S and Andersen, KE and Brandao, FM and Bruynzeel, DP and Bruze, Magnus and Camarasa, JMG and Diepgen, TL and Ducombs, G and Frosch, PJ and Goossens, A and Lachappelle, JM and Lahti, A and Menne, T and Seidenari, S and Tosti, A and Wahlberg, JE},
  issn         = {0105-1873},
  keyword      = {diazolidinyl urea,formaldehyde,imidazolidinyl urea,methyldibromoglutaronitrile,patch test sensitization,parabens,preservatives,quaternium-15,5-chloro-2-methyl-4-isothiazolin-3-one+2-methyl-4-isothiazolin-3-one},
  language     = {eng},
  number       = {4},
  pages        = {207--210},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Monitoring levels of preservative sensitivity in Europe - A 10-year overview (1991-2000)},
  url          = {http://dx.doi.org/10.1034/j.1600-0536.2002.460404.x},
  volume       = {46},
  year         = {2002},
}