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Abnormal palatopharyngeal muscle morphology in sleep-disordered breathing

Lindman, Rolf LU and Stal, PS (2002) In Journal of the Neurological Sciences 195(1). p.11-23
Abstract
The aim of the present study was to investigate whether histopathological changes can be detected in two soft palate muscles, the palatopharyngeus and the uvula, in 11 patients with long duration of sleep-disordered breathing (SDB). Muscle samples were collected froth patients undergoing uvulo-palatopharyngoplasty (UPPP). Reference samples from the corresponding areas were obtained at autopsy froth five previously healthy subjects. Muscle morphology, fibre type and myosin heavy chain (MyHC) compositions were analysed with enzyme-histochemical, immunohistochemical and biochemical techniques. The muscle samples from the patients, and especially those from the palatopharyngeus, showed several morphological abnormalities. The most striking... (More)
The aim of the present study was to investigate whether histopathological changes can be detected in two soft palate muscles, the palatopharyngeus and the uvula, in 11 patients with long duration of sleep-disordered breathing (SDB). Muscle samples were collected froth patients undergoing uvulo-palatopharyngoplasty (UPPP). Reference samples from the corresponding areas were obtained at autopsy froth five previously healthy subjects. Muscle morphology, fibre type and myosin heavy chain (MyHC) compositions were analysed with enzyme-histochemical, immunohistochemical and biochemical techniques. The muscle samples from the patients, and especially those from the palatopharyngeus, showed several morphological abnormalities. The most striking findings were (i) increased amount of connective tissue, (ii) abnormal variability in fibre size, (iii) increased proportion of small-sized fibres, (iv) alterations in fibre type and MyHC compositions, (v) increased frequency of fibres containing developmental MyHC isoforms. Our findings point towards a pathological process of denervation and degeneration in the patient samples. Conclusively. the morphological abnormalities suggest a neuromuscular disorder of the soft palate in SDB patients. (C) 2002 Elsevier Science B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
types, fibre, myosin, muscle, soft palate, apnea, sleep-disordered breathing, snoring
in
Journal of the Neurological Sciences
volume
195
issue
1
pages
11 - 23
publisher
Elsevier
external identifiers
  • wos:000174847900002
  • pmid:11867069
  • scopus:0037086942
ISSN
1878-5883
DOI
10.1016/S0022-510X(01)00676-1
language
English
LU publication?
yes
id
03014f19-52cc-41ae-b61b-b344c807f291 (old id 893618)
date added to LUP
2008-01-23 17:25:37
date last changed
2017-10-22 03:36:59
@article{03014f19-52cc-41ae-b61b-b344c807f291,
  abstract     = {The aim of the present study was to investigate whether histopathological changes can be detected in two soft palate muscles, the palatopharyngeus and the uvula, in 11 patients with long duration of sleep-disordered breathing (SDB). Muscle samples were collected froth patients undergoing uvulo-palatopharyngoplasty (UPPP). Reference samples from the corresponding areas were obtained at autopsy froth five previously healthy subjects. Muscle morphology, fibre type and myosin heavy chain (MyHC) compositions were analysed with enzyme-histochemical, immunohistochemical and biochemical techniques. The muscle samples from the patients, and especially those from the palatopharyngeus, showed several morphological abnormalities. The most striking findings were (i) increased amount of connective tissue, (ii) abnormal variability in fibre size, (iii) increased proportion of small-sized fibres, (iv) alterations in fibre type and MyHC compositions, (v) increased frequency of fibres containing developmental MyHC isoforms. Our findings point towards a pathological process of denervation and degeneration in the patient samples. Conclusively. the morphological abnormalities suggest a neuromuscular disorder of the soft palate in SDB patients. (C) 2002 Elsevier Science B.V. All rights reserved.},
  author       = {Lindman, Rolf and Stal, PS},
  issn         = {1878-5883},
  keyword      = {types,fibre,myosin,muscle,soft palate,apnea,sleep-disordered breathing,snoring},
  language     = {eng},
  number       = {1},
  pages        = {11--23},
  publisher    = {Elsevier},
  series       = {Journal of the Neurological Sciences},
  title        = {Abnormal palatopharyngeal muscle morphology in sleep-disordered breathing},
  url          = {http://dx.doi.org/10.1016/S0022-510X(01)00676-1},
  volume       = {195},
  year         = {2002},
}