Detection and prevention of hepatitis C in dialysis patients and renal transplant recipients. A long-term follow up (1989-january 1997)
(2002) In Journal of Internal Medicine 251(2). p.119-128- Abstract
- Background. Hepatitis C is frequent problem in dialysis wards. Design. A long time (1989-97) follow up of hepatitis C virus (HCV) infection in a Swedish nephrology unit was performed with anti-HCV screening, confirmatory antibody tests, viral RNA detection and molecular characterization. Case histories were reviewed with focus, onset of infection, liver morbidity and mortality. Results. In October 1991, 10% (19 of 184) of the patients in the unit (haemodialysis-, peritoneal dialysis and transplanted patients) were verified or suspected HCV carriers. whilst the number at the end of 1996 was 8% (13 of 157). Most patients were infected before 1991 but only in one case from a known HCV-infected blood donor. No new HCV infections associated... (More)
- Background. Hepatitis C is frequent problem in dialysis wards. Design. A long time (1989-97) follow up of hepatitis C virus (HCV) infection in a Swedish nephrology unit was performed with anti-HCV screening, confirmatory antibody tests, viral RNA detection and molecular characterization. Case histories were reviewed with focus, onset of infection, liver morbidity and mortality. Results. In October 1991, 10% (19 of 184) of the patients in the unit (haemodialysis-, peritoneal dialysis and transplanted patients) were verified or suspected HCV carriers. whilst the number at the end of 1996 was 8% (13 of 157). Most patients were infected before 1991 but only in one case from a known HCV-infected blood donor. No new HCV infections associated with haemodialvsis occurred during the study period. A total of 13 of 24 viremic patients had HCV genotype 2b, a pattern suggesting nosocomial transmission. This was further supported by phylogenetic analysis of HCV viral isolates in seven. HCV viremia was also common in patients with an incomplete anti-HCV antibody pattern as 8 of the 12 indeterminant sera were HCV-RNA positive. Conclusions. Awareness, prevention, identification of infected patients and donor testing limited transmission. Indeterminant recombinant immunoblot assays (RIBA)-results should be regarded with caution as a result of the relative immunodeficiency in uremic patients. Our data indicate nosocomial transmission in several patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/893769
- author
- Almroth, G ; Ekermo, B ; Månsson, Ann-Sofie LU ; Svensson, G and Widell, Anders LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- dialysis, hepatitis C virus, polymerase chain reaction, transmission, recombinant, immunoblot assay
- in
- Journal of Internal Medicine
- volume
- 251
- issue
- 2
- pages
- 119 - 128
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000173753500004
- pmid:11905587
- scopus:0036172536
- ISSN
- 1365-2796
- DOI
- 10.1046/j.1365-2796.2002.00938.x
- language
- English
- LU publication?
- yes
- id
- 13fd0f8d-3903-418c-bd4f-4345c813cc47 (old id 893769)
- date added to LUP
- 2016-04-01 16:47:20
- date last changed
- 2022-02-05 18:37:14
@article{13fd0f8d-3903-418c-bd4f-4345c813cc47, abstract = {{Background. Hepatitis C is frequent problem in dialysis wards. Design. A long time (1989-97) follow up of hepatitis C virus (HCV) infection in a Swedish nephrology unit was performed with anti-HCV screening, confirmatory antibody tests, viral RNA detection and molecular characterization. Case histories were reviewed with focus, onset of infection, liver morbidity and mortality. Results. In October 1991, 10% (19 of 184) of the patients in the unit (haemodialysis-, peritoneal dialysis and transplanted patients) were verified or suspected HCV carriers. whilst the number at the end of 1996 was 8% (13 of 157). Most patients were infected before 1991 but only in one case from a known HCV-infected blood donor. No new HCV infections associated with haemodialvsis occurred during the study period. A total of 13 of 24 viremic patients had HCV genotype 2b, a pattern suggesting nosocomial transmission. This was further supported by phylogenetic analysis of HCV viral isolates in seven. HCV viremia was also common in patients with an incomplete anti-HCV antibody pattern as 8 of the 12 indeterminant sera were HCV-RNA positive. Conclusions. Awareness, prevention, identification of infected patients and donor testing limited transmission. Indeterminant recombinant immunoblot assays (RIBA)-results should be regarded with caution as a result of the relative immunodeficiency in uremic patients. Our data indicate nosocomial transmission in several patients.}}, author = {{Almroth, G and Ekermo, B and Månsson, Ann-Sofie and Svensson, G and Widell, Anders}}, issn = {{1365-2796}}, keywords = {{dialysis; hepatitis C virus; polymerase chain reaction; transmission; recombinant; immunoblot assay}}, language = {{eng}}, number = {{2}}, pages = {{119--128}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Internal Medicine}}, title = {{Detection and prevention of hepatitis C in dialysis patients and renal transplant recipients. A long-term follow up (1989-january 1997)}}, url = {{http://dx.doi.org/10.1046/j.1365-2796.2002.00938.x}}, doi = {{10.1046/j.1365-2796.2002.00938.x}}, volume = {{251}}, year = {{2002}}, }