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Detection and prevention of hepatitis C in dialysis patients and renal transplant recipients. A long-term follow up (1989-january 1997)

Almroth, G; Ekermo, B; Månsson, Ann-Sofie LU ; Svensson, G and Widell, Anders LU (2002) In Journal of Internal Medicine1989-01-01+01:00 251(2). p.119-128
Abstract
Background. Hepatitis C is frequent problem in dialysis wards. Design. A long time (1989-97) follow up of hepatitis C virus (HCV) infection in a Swedish nephrology unit was performed with anti-HCV screening, confirmatory antibody tests, viral RNA detection and molecular characterization. Case histories were reviewed with focus, onset of infection, liver morbidity and mortality. Results. In October 1991, 10% (19 of 184) of the patients in the unit (haemodialysis-, peritoneal dialysis and transplanted patients) were verified or suspected HCV carriers. whilst the number at the end of 1996 was 8% (13 of 157). Most patients were infected before 1991 but only in one case from a known HCV-infected blood donor. No new HCV infections associated... (More)
Background. Hepatitis C is frequent problem in dialysis wards. Design. A long time (1989-97) follow up of hepatitis C virus (HCV) infection in a Swedish nephrology unit was performed with anti-HCV screening, confirmatory antibody tests, viral RNA detection and molecular characterization. Case histories were reviewed with focus, onset of infection, liver morbidity and mortality. Results. In October 1991, 10% (19 of 184) of the patients in the unit (haemodialysis-, peritoneal dialysis and transplanted patients) were verified or suspected HCV carriers. whilst the number at the end of 1996 was 8% (13 of 157). Most patients were infected before 1991 but only in one case from a known HCV-infected blood donor. No new HCV infections associated with haemodialvsis occurred during the study period. A total of 13 of 24 viremic patients had HCV genotype 2b, a pattern suggesting nosocomial transmission. This was further supported by phylogenetic analysis of HCV viral isolates in seven. HCV viremia was also common in patients with an incomplete anti-HCV antibody pattern as 8 of the 12 indeterminant sera were HCV-RNA positive. Conclusions. Awareness, prevention, identification of infected patients and donor testing limited transmission. Indeterminant recombinant immunoblot assays (RIBA)-results should be regarded with caution as a result of the relative immunodeficiency in uremic patients. Our data indicate nosocomial transmission in several patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dialysis, hepatitis C virus, polymerase chain reaction, transmission, recombinant, immunoblot assay
in
Journal of Internal Medicine1989-01-01+01:00
volume
251
issue
2
pages
119 - 128
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000173753500004
  • pmid:11905587
  • scopus:0036172536
ISSN
1365-2796
DOI
10.1046/j.1365-2796.2002.00938.x
language
English
LU publication?
yes
id
13fd0f8d-3903-418c-bd4f-4345c813cc47 (old id 893769)
date added to LUP
2008-01-15 13:18:26
date last changed
2017-10-01 04:49:10
@article{13fd0f8d-3903-418c-bd4f-4345c813cc47,
  abstract     = {Background. Hepatitis C is frequent problem in dialysis wards. Design. A long time (1989-97) follow up of hepatitis C virus (HCV) infection in a Swedish nephrology unit was performed with anti-HCV screening, confirmatory antibody tests, viral RNA detection and molecular characterization. Case histories were reviewed with focus, onset of infection, liver morbidity and mortality. Results. In October 1991, 10% (19 of 184) of the patients in the unit (haemodialysis-, peritoneal dialysis and transplanted patients) were verified or suspected HCV carriers. whilst the number at the end of 1996 was 8% (13 of 157). Most patients were infected before 1991 but only in one case from a known HCV-infected blood donor. No new HCV infections associated with haemodialvsis occurred during the study period. A total of 13 of 24 viremic patients had HCV genotype 2b, a pattern suggesting nosocomial transmission. This was further supported by phylogenetic analysis of HCV viral isolates in seven. HCV viremia was also common in patients with an incomplete anti-HCV antibody pattern as 8 of the 12 indeterminant sera were HCV-RNA positive. Conclusions. Awareness, prevention, identification of infected patients and donor testing limited transmission. Indeterminant recombinant immunoblot assays (RIBA)-results should be regarded with caution as a result of the relative immunodeficiency in uremic patients. Our data indicate nosocomial transmission in several patients.},
  author       = {Almroth, G and Ekermo, B and Månsson, Ann-Sofie and Svensson, G and Widell, Anders},
  issn         = {1365-2796},
  keyword      = {dialysis,hepatitis C virus,polymerase chain reaction,transmission,recombinant,immunoblot assay},
  language     = {eng},
  number       = {2},
  pages        = {119--128},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine1989-01-01+01:00},
  title        = {Detection and prevention of hepatitis C in dialysis patients and renal transplant recipients. A long-term follow up (1989-january 1997)},
  url          = {http://dx.doi.org/10.1046/j.1365-2796.2002.00938.x},
  volume       = {251},
  year         = {2002},
}