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Selected oxidized fragrance terpenes are common contact allergens

Matura, M; Skold, M; Borje, A; Andersen, KE; Bruze, Magnus LU ; Frosch, P; Goossens, A; Johansen, JD; Svedman, C and White, IR, et al. (2005) In Contact Dermatitis 52(6). p.320-328
Abstract
Terpenes are widely used fragrance compounds in fine fragrances, but also in domestic and occupational products. Terpenes oxidize easily due to autoxidation on air exposure. Previous studies have shown that limonene, linalool and caryophyllene are not allergenic themselves but readily form allergenic products on air-exposure. This study aimed to determine the frequency and characteristics of allergic reactions to selected oxidized fragrance terpenes other than limonene. In total 1511 consecutive dermatitis patients in 6 European dermatology centres were patch tested with oxidized fragrance terpenes and some oxidation fractions and compounds. Oxidized linalool and its hydroperoxide fraction were found to be common contact allergens. Of the... (More)
Terpenes are widely used fragrance compounds in fine fragrances, but also in domestic and occupational products. Terpenes oxidize easily due to autoxidation on air exposure. Previous studies have shown that limonene, linalool and caryophyllene are not allergenic themselves but readily form allergenic products on air-exposure. This study aimed to determine the frequency and characteristics of allergic reactions to selected oxidized fragrance terpenes other than limonene. In total 1511 consecutive dermatitis patients in 6 European dermatology centres were patch tested with oxidized fragrance terpenes and some oxidation fractions and compounds. Oxidized linalool and its hydroperoxide fraction were found to be common contact allergens. Of the patients tested, 1.3% showed a positive reaction to oxidized linalool and 1.1% to the hydroperoxide fraction. About 0.5% of the patients reacted to oxidized caryophyllene whereas 1 patient reacted to oxidized myrcene. Of the patients reacting to the oxidized terpenes, 58% had fragrance-related contact allergy and/or a positive history for adverse reaction to fragrances. Autoxidation of fragrance terpenes contributes greatly to fragrance allergy, which emphasizes the need of testing with compounds that patients are actually exposed to and not only with the ingredients originally applied in commercial formulations. (Less)
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Contribution to journal
publication status
published
subject
keywords
caryophyllene, autoxidation, allergic contact dermatitis, fragrance, allergy, fragrance mix, hydroperoxides, linalool, myrcene, oxidation, patch testing, products
in
Contact Dermatitis
volume
52
issue
6
pages
320 - 328
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000229495200007
  • pmid:15932583
  • scopus:20544478198
ISSN
0105-1873
DOI
10.1111/j.0105-1873.2005.00605.x
language
English
LU publication?
yes
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fca7236f-3978-422f-9774-9a0684965d5c (old id 895406)
date added to LUP
2008-01-16 14:43:28
date last changed
2017-11-12 03:18:06
@article{fca7236f-3978-422f-9774-9a0684965d5c,
  abstract     = {Terpenes are widely used fragrance compounds in fine fragrances, but also in domestic and occupational products. Terpenes oxidize easily due to autoxidation on air exposure. Previous studies have shown that limonene, linalool and caryophyllene are not allergenic themselves but readily form allergenic products on air-exposure. This study aimed to determine the frequency and characteristics of allergic reactions to selected oxidized fragrance terpenes other than limonene. In total 1511 consecutive dermatitis patients in 6 European dermatology centres were patch tested with oxidized fragrance terpenes and some oxidation fractions and compounds. Oxidized linalool and its hydroperoxide fraction were found to be common contact allergens. Of the patients tested, 1.3% showed a positive reaction to oxidized linalool and 1.1% to the hydroperoxide fraction. About 0.5% of the patients reacted to oxidized caryophyllene whereas 1 patient reacted to oxidized myrcene. Of the patients reacting to the oxidized terpenes, 58% had fragrance-related contact allergy and/or a positive history for adverse reaction to fragrances. Autoxidation of fragrance terpenes contributes greatly to fragrance allergy, which emphasizes the need of testing with compounds that patients are actually exposed to and not only with the ingredients originally applied in commercial formulations.},
  author       = {Matura, M and Skold, M and Borje, A and Andersen, KE and Bruze, Magnus and Frosch, P and Goossens, A and Johansen, JD and Svedman, C and White, IR and Karlberg, AT},
  issn         = {0105-1873},
  keyword      = {caryophyllene,autoxidation,allergic contact dermatitis,fragrance,allergy,fragrance mix,hydroperoxides,linalool,myrcene,oxidation,patch testing,products},
  language     = {eng},
  number       = {6},
  pages        = {320--328},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Selected oxidized fragrance terpenes are common contact allergens},
  url          = {http://dx.doi.org/10.1111/j.0105-1873.2005.00605.x},
  volume       = {52},
  year         = {2005},
}