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Hyperprolactinemia in some Meniere patients even in the absence of incapacitating vertigo

Falkenius-Schmidt, Karolina LU ; Rydmarker, S and Horner, KC (2005) In Hearing Research 203(1-2). p.154-158
Abstract
Stress can be a significant factor influencing ear pathologies and is often reported to trigger the symptoms of Meniere's disease. Both physiological and psychological stress provokes the release of prolactin from the pituitary thus allowing the classification of prolactin as a major stress hormone. We investigated the level of the stress hormone prolactin in a Swedish population with early symptoms of Meniere's disease. The median prolactin level in the Meniere patients (n = 33) was not significantly different from that of non-Meniere patients (n = 23). However, in the Meniere group one female (90 year old) had prolactin levels in the upper normal range for women, one male (77 year old) had prolactin levels above the normal limit for men,... (More)
Stress can be a significant factor influencing ear pathologies and is often reported to trigger the symptoms of Meniere's disease. Both physiological and psychological stress provokes the release of prolactin from the pituitary thus allowing the classification of prolactin as a major stress hormone. We investigated the level of the stress hormone prolactin in a Swedish population with early symptoms of Meniere's disease. The median prolactin level in the Meniere patients (n = 33) was not significantly different from that of non-Meniere patients (n = 23). However, in the Meniere group one female (90 year old) had prolactin levels in the upper normal range for women, one male (77 year old) had prolactin levels above the normal limit for men, and a third patient (76 year old female) presented hyper prolactinemia with more than twice the normal level. MR1 confirmed a pituitary adenoma in this patient. This study provides further support for the recent report of hyperprolactinemia in some patients with long-standing Meniere's disease and presenting incapacitating vertigo in France. The data emphasize the likely implication of stress in this pathology where the stress hormone prolactin is likely to represent one actor in a complex hormonal imbalance affecting the inner ear. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Meniere's disease, stress, hyperprolactinemia, pituitary adenoma, vertigo, hearing
in
Hearing Research
volume
203
issue
1-2
pages
154 - 158
publisher
Elsevier
external identifiers
  • wos:000229166300017
  • pmid:15855040
  • scopus:18044386971
ISSN
0378-5955
DOI
10.1016/j.heares.2004.11.015
language
English
LU publication?
yes
id
e4241abc-4561-414f-99a9-3b2d06c8eca5 (old id 895497)
date added to LUP
2008-01-11 15:26:59
date last changed
2017-07-30 03:49:16
@article{e4241abc-4561-414f-99a9-3b2d06c8eca5,
  abstract     = {Stress can be a significant factor influencing ear pathologies and is often reported to trigger the symptoms of Meniere's disease. Both physiological and psychological stress provokes the release of prolactin from the pituitary thus allowing the classification of prolactin as a major stress hormone. We investigated the level of the stress hormone prolactin in a Swedish population with early symptoms of Meniere's disease. The median prolactin level in the Meniere patients (n = 33) was not significantly different from that of non-Meniere patients (n = 23). However, in the Meniere group one female (90 year old) had prolactin levels in the upper normal range for women, one male (77 year old) had prolactin levels above the normal limit for men, and a third patient (76 year old female) presented hyper prolactinemia with more than twice the normal level. MR1 confirmed a pituitary adenoma in this patient. This study provides further support for the recent report of hyperprolactinemia in some patients with long-standing Meniere's disease and presenting incapacitating vertigo in France. The data emphasize the likely implication of stress in this pathology where the stress hormone prolactin is likely to represent one actor in a complex hormonal imbalance affecting the inner ear.},
  author       = {Falkenius-Schmidt, Karolina and Rydmarker, S and Horner, KC},
  issn         = {0378-5955},
  keyword      = {Meniere's disease,stress,hyperprolactinemia,pituitary adenoma,vertigo,hearing},
  language     = {eng},
  number       = {1-2},
  pages        = {154--158},
  publisher    = {Elsevier},
  series       = {Hearing Research},
  title        = {Hyperprolactinemia in some Meniere patients even in the absence of incapacitating vertigo},
  url          = {http://dx.doi.org/10.1016/j.heares.2004.11.015},
  volume       = {203},
  year         = {2005},
}