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Effect of mobilization of bone marrow stem cells by granulocyte colony stimulating factor on clinical symptoms, left ventricular perfusion and function in patients with severe chronic ischemic heart disease

Wang, YZ; Tägil, Kristina LU ; Ripa, RS; Nilsson, JC; Carstensen, S; Jorgensen, E; Sondergaard, L; Hesse, B; Johnsen, HE and Kastrup, J (2005) In International Journal of Cardiology 100(3). p.477-483
Abstract
Objectives: A phase I safety and efficacy study with granulocyte colony stimulating factor (G-CSF) mobilization of bone marrow stem cells to induce vasculogenesis in patients with severe ischemic heart disease (IHD) was conducted. Design, patients and results: 29 patients with IHD participated in the study. Thirteen patients were treated with G-CSF for 6 days and 16 patients served as controls. G-CSF treatment was without any serious adverse events. Four patients were "poor mobilizers" with a maximal increase in CD34+ cells to 5,000 +/- 700/mL blood (mean +/- S.D.) compared to 28,900 +/- 5,100/mL blood in "mobilizers". At the follow-up, G-CSF treated had improved in CCS classification, NTG consumption and angina attacks, but the controls... (More)
Objectives: A phase I safety and efficacy study with granulocyte colony stimulating factor (G-CSF) mobilization of bone marrow stem cells to induce vasculogenesis in patients with severe ischemic heart disease (IHD) was conducted. Design, patients and results: 29 patients with IHD participated in the study. Thirteen patients were treated with G-CSF for 6 days and 16 patients served as controls. G-CSF treatment was without any serious adverse events. Four patients were "poor mobilizers" with a maximal increase in CD34+ cells to 5,000 +/- 700/mL blood (mean +/- S.D.) compared to 28,900 +/- 5,100/mL blood in "mobilizers". At the follow-up, G-CSF treated had improved in CCS classification, NTG consumption and angina attacks, but the controls only in CCS classification. No difference was seen between the two groups. The decline in NTG consumption tended to be significant in "mobilizers" compared to controls. Myocardial perfusion was unchanged at adenosine stress single photon emission computerized tomography (SPECT) or magnetic resonance images (MRI). Left ventricular ejection fraction decreased from 57% to 52% (p < 0.01, MRI) and from 48% to 44% (p=0.07, SPECT) in G-CSF treated, but was unchanged measured with echocardiography. Conclusions: Treatment by G-CSF improved symptoms but not signs of myocardial ischemia in patients with severe IHD. The effects seemed related to mobilization of stem cells. An adverse effect on ejection fraction could not be excluded. (c) 2005 Published by Elsevier Ireland Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
G-CSF, ejection fraction, left ventricular, ischemic heart disease, stem cells, vasculogenesis
in
International Journal of Cardiology
volume
100
issue
3
pages
477 - 483
publisher
Elsevier
external identifiers
  • wos:000228814600019
  • pmid:15837093
  • scopus:20144387706
ISSN
0167-5273
DOI
10.1016/j.ijcard.2004.12.006
language
English
LU publication?
yes
id
38968d6f-a548-4909-9fbb-a14640b869de (old id 896718)
date added to LUP
2008-01-21 13:17:23
date last changed
2017-10-01 03:35:21
@article{38968d6f-a548-4909-9fbb-a14640b869de,
  abstract     = {Objectives: A phase I safety and efficacy study with granulocyte colony stimulating factor (G-CSF) mobilization of bone marrow stem cells to induce vasculogenesis in patients with severe ischemic heart disease (IHD) was conducted. Design, patients and results: 29 patients with IHD participated in the study. Thirteen patients were treated with G-CSF for 6 days and 16 patients served as controls. G-CSF treatment was without any serious adverse events. Four patients were "poor mobilizers" with a maximal increase in CD34+ cells to 5,000 +/- 700/mL blood (mean +/- S.D.) compared to 28,900 +/- 5,100/mL blood in "mobilizers". At the follow-up, G-CSF treated had improved in CCS classification, NTG consumption and angina attacks, but the controls only in CCS classification. No difference was seen between the two groups. The decline in NTG consumption tended to be significant in "mobilizers" compared to controls. Myocardial perfusion was unchanged at adenosine stress single photon emission computerized tomography (SPECT) or magnetic resonance images (MRI). Left ventricular ejection fraction decreased from 57% to 52% (p &lt; 0.01, MRI) and from 48% to 44% (p=0.07, SPECT) in G-CSF treated, but was unchanged measured with echocardiography. Conclusions: Treatment by G-CSF improved symptoms but not signs of myocardial ischemia in patients with severe IHD. The effects seemed related to mobilization of stem cells. An adverse effect on ejection fraction could not be excluded. (c) 2005 Published by Elsevier Ireland Ltd.},
  author       = {Wang, YZ and Tägil, Kristina and Ripa, RS and Nilsson, JC and Carstensen, S and Jorgensen, E and Sondergaard, L and Hesse, B and Johnsen, HE and Kastrup, J},
  issn         = {0167-5273},
  keyword      = {G-CSF,ejection fraction,left ventricular,ischemic heart disease,stem cells,vasculogenesis},
  language     = {eng},
  number       = {3},
  pages        = {477--483},
  publisher    = {Elsevier},
  series       = {International Journal of Cardiology},
  title        = {Effect of mobilization of bone marrow stem cells by granulocyte colony stimulating factor on clinical symptoms, left ventricular perfusion and function in patients with severe chronic ischemic heart disease},
  url          = {http://dx.doi.org/10.1016/j.ijcard.2004.12.006},
  volume       = {100},
  year         = {2005},
}