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Aortic stiffness and left ventricular diastolic function in children with well-functioning bicuspid aortic valves

Weismann, Constance G LU ; Lombardi, Kristin C; Grell, Bernhard S; Northrup, Veronika and Sugeng, Lissa (2016) In European Heart Journal Cardiovascular Imaging 17(2). p.30-225
Abstract

AIMS: Aortic stiffness and diastolic function are abnormal in adults with bicuspid aortic valves (BAVs). The goal of this study was to determine the relationship between aortic stiffness and left ventricular (LV) diastolic impairment in children with well-functioning BAV and no associated congenital heart disease.

METHODS AND RESULTS: This is a retrospective review of echocardiograms in children with isolated BAV (group BAV; N = 50) and healthy frequency-matched controls (group Control; N = 50). We analysed LV systolic and diastolic function, proximal and distal ascending aortic stiffness index (SI), distensibility, and strain. Age range was 0.2-20 (median 11) years. There was no significant difference in blood pressure,... (More)

AIMS: Aortic stiffness and diastolic function are abnormal in adults with bicuspid aortic valves (BAVs). The goal of this study was to determine the relationship between aortic stiffness and left ventricular (LV) diastolic impairment in children with well-functioning BAV and no associated congenital heart disease.

METHODS AND RESULTS: This is a retrospective review of echocardiograms in children with isolated BAV (group BAV; N = 50) and healthy frequency-matched controls (group Control; N = 50). We analysed LV systolic and diastolic function, proximal and distal ascending aortic stiffness index (SI), distensibility, and strain. Age range was 0.2-20 (median 11) years. There was no significant difference in blood pressure, normalized LV size and systolic function between the groups. Several parameters of LV diastolic function were lower in group BAV compared with group Control (e.g. septal E': BAV 12 ± 2.3 cm/s; Control 13.5 ± 1.8 cm/s, P < 0.001). All parameters of proximal and distal ascending aortic elasticity were abnormal in group BAV vs. Control (SI proximal ascending aorta: BAV 4.2 ± 1.6; Control 3.0 ± 0.9, P < 0.001). There was no significant correlation between parameters of aortic elasticity and diastolic function. In a subgroup analysis of children with fusion of the right-non vs. right-left coronary cusps, there was no significant difference for any of the parameters analysed.

CONCLUSION: Even children with well-functioning isolated BAV have abnormalities in aortic elasticity and diastolic function when compared with the Control group. However, a relationship between the two could not be established.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Aortic Valve/abnormalities, Case-Control Studies, Child, Child, Preschool, Diastole, Echocardiography, Female, Heart Valve Diseases/diagnostic imaging, Humans, Infant, Male, Retrospective Studies, Vascular Stiffness, Ventricular Dysfunction, Left/diagnostic imaging, Young Adult
in
European Heart Journal Cardiovascular Imaging
volume
17
issue
2
pages
6 pages
publisher
Oxford University Press
external identifiers
  • scopus:84978842999
ISSN
2047-2412
DOI
10.1093/ehjci/jev151
language
English
LU publication?
no
id
896b9c8a-cede-423d-b4ea-00385e7169d5
date added to LUP
2019-01-25 14:42:10
date last changed
2019-10-23 06:07:26
@article{896b9c8a-cede-423d-b4ea-00385e7169d5,
  abstract     = {<p>AIMS: Aortic stiffness and diastolic function are abnormal in adults with bicuspid aortic valves (BAVs). The goal of this study was to determine the relationship between aortic stiffness and left ventricular (LV) diastolic impairment in children with well-functioning BAV and no associated congenital heart disease.</p><p>METHODS AND RESULTS: This is a retrospective review of echocardiograms in children with isolated BAV (group BAV; N = 50) and healthy frequency-matched controls (group Control; N = 50). We analysed LV systolic and diastolic function, proximal and distal ascending aortic stiffness index (SI), distensibility, and strain. Age range was 0.2-20 (median 11) years. There was no significant difference in blood pressure, normalized LV size and systolic function between the groups. Several parameters of LV diastolic function were lower in group BAV compared with group Control (e.g. septal E': BAV 12 ± 2.3 cm/s; Control 13.5 ± 1.8 cm/s, P &lt; 0.001). All parameters of proximal and distal ascending aortic elasticity were abnormal in group BAV vs. Control (SI proximal ascending aorta: BAV 4.2 ± 1.6; Control 3.0 ± 0.9, P &lt; 0.001). There was no significant correlation between parameters of aortic elasticity and diastolic function. In a subgroup analysis of children with fusion of the right-non vs. right-left coronary cusps, there was no significant difference for any of the parameters analysed.</p><p>CONCLUSION: Even children with well-functioning isolated BAV have abnormalities in aortic elasticity and diastolic function when compared with the Control group. However, a relationship between the two could not be established.</p>},
  author       = {Weismann, Constance G and Lombardi, Kristin C and Grell, Bernhard S and Northrup, Veronika and Sugeng, Lissa},
  issn         = {2047-2412},
  keyword      = {Adolescent,Aortic Valve/abnormalities,Case-Control Studies,Child,Child, Preschool,Diastole,Echocardiography,Female,Heart Valve Diseases/diagnostic imaging,Humans,Infant,Male,Retrospective Studies,Vascular Stiffness,Ventricular Dysfunction, Left/diagnostic imaging,Young Adult},
  language     = {eng},
  number       = {2},
  pages        = {30--225},
  publisher    = {Oxford University Press},
  series       = {European Heart Journal Cardiovascular Imaging},
  title        = {Aortic stiffness and left ventricular diastolic function in children with well-functioning bicuspid aortic valves},
  url          = {http://dx.doi.org/10.1093/ehjci/jev151},
  volume       = {17},
  year         = {2016},
}