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Childhood idiopathic thrombocytopenic purpura in the Nordic countries: Epidemiology and predictors of chronic disease

Zeller, B; Rajantie, J; Hedlund-Treutiger, I; Tedgård, Ulf LU ; Wesenberg, F; Jonsson, AG; Henter, JI and Rosthoj, S (2005) In Acta Pædiatrica 94(2). p.178-184
Abstract
Aim: To describe the epidemiology of idiopathic thrombocytopenic purpura (ITP) in the Nordic countries, to define clinical subgroups and to investigate factors predicting chronic disease. Methods: A prospective registration was done from 1998 to 2000, including all children with newly diagnosed ITP aged 0-14 y and at least one platelet count <30 x 10(9)/l. Results: 506 children were registered and 423 followed for 6 mo. The incidence was 4.8/10(5) per year. Most children were aged 0-7 y (78%), with a predominance of boys, while patients aged 8-14 y had equal representation of the two sexes. There were seasonal variations determined by variations in postinfectious cases with sudden onset. The platelet count was <10x10(9)/l in 58%, but... (More)
Aim: To describe the epidemiology of idiopathic thrombocytopenic purpura (ITP) in the Nordic countries, to define clinical subgroups and to investigate factors predicting chronic disease. Methods: A prospective registration was done from 1998 to 2000, including all children with newly diagnosed ITP aged 0-14 y and at least one platelet count <30 x 10(9)/l. Results: 506 children were registered and 423 followed for 6 mo. The incidence was 4.8/10(5) per year. Most children were aged 0-7 y (78%), with a predominance of boys, while patients aged 8-14 y had equal representation of the two sexes. There were seasonal variations determined by variations in postinfectious cases with sudden onset. The platelet count was <10x10(9)/l in 58%, but bleeding manifestations were mild or moderate in 97%. The insidious form (symptoms for more than 2 wk) was more frequent in older children and girls, showed little seasonal variation, had milder manifestations and ran a chronic course in more than half the cases. Intracranial haemorrhages did not occur in the first 6 mo after diagnosis. Chronic ITP developed in 25%. The strongest predictor of chronic disease was insidious onset of symptoms (OR 5.97). Conclusion: In the Nordic countries, ITP mainly affects children aged 0-7 y, with a winter bulk of postinfectious cases superimposed on a steady occurrence of non-infectious cases. Clinically, it may be useful to distinguish between children with sudden versus insidious onset of symptoms rather than between different age groups. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
epidemiology, haemorrhage, childhood, purpura, thrombocytopenia
in
Acta Pædiatrica
volume
94
issue
2
pages
178 - 184
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • pmid:15981751
  • wos:000227783700011
  • scopus:14844298810
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2005.tb01887.x
language
English
LU publication?
yes
id
729f4bb2-65bd-481e-a9c1-eb6b19aeb442 (old id 897032)
date added to LUP
2008-01-21 13:31:20
date last changed
2017-11-19 04:09:24
@article{729f4bb2-65bd-481e-a9c1-eb6b19aeb442,
  abstract     = {Aim: To describe the epidemiology of idiopathic thrombocytopenic purpura (ITP) in the Nordic countries, to define clinical subgroups and to investigate factors predicting chronic disease. Methods: A prospective registration was done from 1998 to 2000, including all children with newly diagnosed ITP aged 0-14 y and at least one platelet count &lt;30 x 10(9)/l. Results: 506 children were registered and 423 followed for 6 mo. The incidence was 4.8/10(5) per year. Most children were aged 0-7 y (78%), with a predominance of boys, while patients aged 8-14 y had equal representation of the two sexes. There were seasonal variations determined by variations in postinfectious cases with sudden onset. The platelet count was &lt;10x10(9)/l in 58%, but bleeding manifestations were mild or moderate in 97%. The insidious form (symptoms for more than 2 wk) was more frequent in older children and girls, showed little seasonal variation, had milder manifestations and ran a chronic course in more than half the cases. Intracranial haemorrhages did not occur in the first 6 mo after diagnosis. Chronic ITP developed in 25%. The strongest predictor of chronic disease was insidious onset of symptoms (OR 5.97). Conclusion: In the Nordic countries, ITP mainly affects children aged 0-7 y, with a winter bulk of postinfectious cases superimposed on a steady occurrence of non-infectious cases. Clinically, it may be useful to distinguish between children with sudden versus insidious onset of symptoms rather than between different age groups.},
  author       = {Zeller, B and Rajantie, J and Hedlund-Treutiger, I and Tedgård, Ulf and Wesenberg, F and Jonsson, AG and Henter, JI and Rosthoj, S},
  issn         = {1651-2227},
  keyword      = {epidemiology,haemorrhage,childhood,purpura,thrombocytopenia},
  language     = {eng},
  number       = {2},
  pages        = {178--184},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Childhood idiopathic thrombocytopenic purpura in the Nordic countries: Epidemiology and predictors of chronic disease},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2005.tb01887.x},
  volume       = {94},
  year         = {2005},
}