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Weight change and mortality: The Nord-Trondelag Health Study

Droyvold, WB; Nilsen, TIL; Lydersen, S; Midthjell, K; Nilsson, Peter LU ; Nilsson, J and Holmen, J (2005) In Journal of Internal Medicine 257(4). p.338-345
Abstract
Objectives. The prevalence of obesity is increasing. Overweight and obese people have increased mortality compared with normal weight people. We investigated the effect of weight change on mortality. Design. Prospective population study. Setting. We utilized data from two large population-based health studies conducted in 1984-86 and 1995-97 respectively. Cox proportional hazards models were used to calculate mortality rate ratios (RRs) with 95% confidence intervals (CIs) between people with a stable weight and people who lost or gained weight. Subjects. Totally 20 542 men and 23 712 women aged 20 years or more, without cardiovascular disease or diabetes at the first survey and without a history of cancer at the second survey were followed... (More)
Objectives. The prevalence of obesity is increasing. Overweight and obese people have increased mortality compared with normal weight people. We investigated the effect of weight change on mortality. Design. Prospective population study. Setting. We utilized data from two large population-based health studies conducted in 1984-86 and 1995-97 respectively. Cox proportional hazards models were used to calculate mortality rate ratios (RRs) with 95% confidence intervals (CIs) between people with a stable weight and people who lost or gained weight. Subjects. Totally 20 542 men and 23 712 women aged 20 years or more, without cardiovascular disease or diabetes at the first survey and without a history of cancer at the second survey were followed up on all-cause mortality for 5 years after the second survey. Results. We found no association between weight gain and mortality. People who lost weight had a higher total mortality rate compared with those who were weight stable [RR was 1.6 (95% CI: 1.4-1.8) in men and 1.7 (95% CI: 1.5-2.0) in women]. Similar associations were found for cardiovascular and noncardiovascular mortality. Additional analysis showed a linear increase in mortality rates across categories of weight loss for both men and women (P < 0.001). There was a statistically significant interaction between weight change and initial BMI, but only amongst men (P = 0.001). Conclusions. Weight loss, but not weight gain, was associated with increased mortality amongst men and women. Although underlying undiagnosed disease is the most plausible explanation for this finding, the similar associations found for total mortality, cardiovascular mortality, and noncardiovascular mortality makes the causal pathway somewhat enigmatic. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
weight change, smoking, body mass index, physical activity
in
Journal of Internal Medicine
volume
257
issue
4
pages
338 - 345
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000227594000003
  • pmid:15788003
  • scopus:16244379203
ISSN
1365-2796
DOI
10.1111/j.1365-2796.2005.01458.x
language
English
LU publication?
yes
id
72516fae-fabe-4575-bd49-4d5c02c8d472 (old id 897073)
date added to LUP
2008-01-11 14:36:58
date last changed
2017-01-15 04:14:39
@article{72516fae-fabe-4575-bd49-4d5c02c8d472,
  abstract     = {Objectives. The prevalence of obesity is increasing. Overweight and obese people have increased mortality compared with normal weight people. We investigated the effect of weight change on mortality. Design. Prospective population study. Setting. We utilized data from two large population-based health studies conducted in 1984-86 and 1995-97 respectively. Cox proportional hazards models were used to calculate mortality rate ratios (RRs) with 95% confidence intervals (CIs) between people with a stable weight and people who lost or gained weight. Subjects. Totally 20 542 men and 23 712 women aged 20 years or more, without cardiovascular disease or diabetes at the first survey and without a history of cancer at the second survey were followed up on all-cause mortality for 5 years after the second survey. Results. We found no association between weight gain and mortality. People who lost weight had a higher total mortality rate compared with those who were weight stable [RR was 1.6 (95% CI: 1.4-1.8) in men and 1.7 (95% CI: 1.5-2.0) in women]. Similar associations were found for cardiovascular and noncardiovascular mortality. Additional analysis showed a linear increase in mortality rates across categories of weight loss for both men and women (P &lt; 0.001). There was a statistically significant interaction between weight change and initial BMI, but only amongst men (P = 0.001). Conclusions. Weight loss, but not weight gain, was associated with increased mortality amongst men and women. Although underlying undiagnosed disease is the most plausible explanation for this finding, the similar associations found for total mortality, cardiovascular mortality, and noncardiovascular mortality makes the causal pathway somewhat enigmatic.},
  author       = {Droyvold, WB and Nilsen, TIL and Lydersen, S and Midthjell, K and Nilsson, Peter and Nilsson, J and Holmen, J},
  issn         = {1365-2796},
  keyword      = {weight change,smoking,body mass index,physical activity},
  language     = {eng},
  number       = {4},
  pages        = {338--345},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine},
  title        = {Weight change and mortality: The Nord-Trondelag Health Study},
  url          = {http://dx.doi.org/10.1111/j.1365-2796.2005.01458.x},
  volume       = {257},
  year         = {2005},
}