Microalbuminuria and risk factors in type 1 and type 2 diabetic patients
(2005) In Diabetes Research and Clinical Practice 67(3). p.258-266- Abstract
- A prospective study of normoalbutninuric diabetic patients was performed between 1997 and 2002 on 4097 type 1 and 6513 type 2 diabetic patients from the Swedish National Diabetes Register (NDR); mean study period, 4.6 years. The strongest independent baseline risk factors for the development of microalbuminuria (20-200 mug/min) were elevated HbA(1c) and diabetes duration in both types 1 and 2 diabetic patients. Other risk factors were high BMI, elevated systolic and diastolic BP in type 2 patients, and antihypertensive therapy in type 1 patients. A subsequent larger cross-sectional study in 2002 showed that established microalbummuria was independently associated with HbA(1c) diabetes duration, systolic BP, BMI, smoking and triglycerides... (More)
- A prospective study of normoalbutninuric diabetic patients was performed between 1997 and 2002 on 4097 type 1 and 6513 type 2 diabetic patients from the Swedish National Diabetes Register (NDR); mean study period, 4.6 years. The strongest independent baseline risk factors for the development of microalbuminuria (20-200 mug/min) were elevated HbA(1c) and diabetes duration in both types 1 and 2 diabetic patients. Other risk factors were high BMI, elevated systolic and diastolic BP in type 2 patients, and antihypertensive therapy in type 1 patients. A subsequent larger cross-sectional study in 2002 showed that established microalbummuria was independently associated with HbA(1c) diabetes duration, systolic BP, BMI, smoking and triglycerides in types 1 and 2 diabetic patients, and also with HDL-cholesterol in type 2 patients. Relatively few types 1 and 2 patients with microalbummuria achieved treatment targets of HbA(1c) < 6.5% (21-48%), BP < 130/85 mmHg (33-13%), cholesterol < 5 mmol/l (48-46%), triglycerides < 1.7 mmol/l (8348%) and BMI < 25 kg/m(2) (50-18%), respectively. In conclusion, high HbA(1c), BP and BMI were independent risk factors for the development of microalbuminuria in types 1 and 2 diabetic patients. These risk factors as well as triglycerides, HDL-cholesterol and smoking were independently associated with established microalbuminuria. Treatment targets were achieved by a relatively few patients with microalbuminuria. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/897177
- author
- Cederholm, J ; Eliasson, B ; Nilsson, Peter LU ; Weiss, L and Gudbjornsdottir, S
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- diabetes, register, microalbuminuria, hypertension, body mass index
- in
- Diabetes Research and Clinical Practice
- volume
- 67
- issue
- 3
- pages
- 258 - 266
- publisher
- Elsevier
- external identifiers
-
- wos:000227425700010
- pmid:15713359
- scopus:13844275224
- ISSN
- 1872-8227
- DOI
- 10.1016/j.diabres.2004.07.021
- language
- English
- LU publication?
- yes
- id
- 8d0706a8-bcc1-4550-b840-1167347a8dc8 (old id 897177)
- date added to LUP
- 2016-04-01 11:37:39
- date last changed
- 2022-02-18 02:28:59
@article{8d0706a8-bcc1-4550-b840-1167347a8dc8, abstract = {{A prospective study of normoalbutninuric diabetic patients was performed between 1997 and 2002 on 4097 type 1 and 6513 type 2 diabetic patients from the Swedish National Diabetes Register (NDR); mean study period, 4.6 years. The strongest independent baseline risk factors for the development of microalbuminuria (20-200 mug/min) were elevated HbA(1c) and diabetes duration in both types 1 and 2 diabetic patients. Other risk factors were high BMI, elevated systolic and diastolic BP in type 2 patients, and antihypertensive therapy in type 1 patients. A subsequent larger cross-sectional study in 2002 showed that established microalbummuria was independently associated with HbA(1c) diabetes duration, systolic BP, BMI, smoking and triglycerides in types 1 and 2 diabetic patients, and also with HDL-cholesterol in type 2 patients. Relatively few types 1 and 2 patients with microalbummuria achieved treatment targets of HbA(1c) < 6.5% (21-48%), BP < 130/85 mmHg (33-13%), cholesterol < 5 mmol/l (48-46%), triglycerides < 1.7 mmol/l (8348%) and BMI < 25 kg/m(2) (50-18%), respectively. In conclusion, high HbA(1c), BP and BMI were independent risk factors for the development of microalbuminuria in types 1 and 2 diabetic patients. These risk factors as well as triglycerides, HDL-cholesterol and smoking were independently associated with established microalbuminuria. Treatment targets were achieved by a relatively few patients with microalbuminuria.}}, author = {{Cederholm, J and Eliasson, B and Nilsson, Peter and Weiss, L and Gudbjornsdottir, S}}, issn = {{1872-8227}}, keywords = {{diabetes; register; microalbuminuria; hypertension; body mass index}}, language = {{eng}}, number = {{3}}, pages = {{258--266}}, publisher = {{Elsevier}}, series = {{Diabetes Research and Clinical Practice}}, title = {{Microalbuminuria and risk factors in type 1 and type 2 diabetic patients}}, url = {{http://dx.doi.org/10.1016/j.diabres.2004.07.021}}, doi = {{10.1016/j.diabres.2004.07.021}}, volume = {{67}}, year = {{2005}}, }