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Microalbuminuria and risk factors in type 1 and type 2 diabetic patients

Cederholm, J; Eliasson, B; Nilsson, Peter LU ; Weiss, L and Gudbjornsdottir, S (2005) In Diabetes Research and Clinical Practice 67(3). p.258-266
Abstract
A prospective study of normoalbutninuric diabetic patients was performed between 1997 and 2002 on 4097 type 1 and 6513 type 2 diabetic patients from the Swedish National Diabetes Register (NDR); mean study period, 4.6 years. The strongest independent baseline risk factors for the development of microalbuminuria (20-200 mug/min) were elevated HbA(1c) and diabetes duration in both types 1 and 2 diabetic patients. Other risk factors were high BMI, elevated systolic and diastolic BP in type 2 patients, and antihypertensive therapy in type 1 patients. A subsequent larger cross-sectional study in 2002 showed that established microalbummuria was independently associated with HbA(1c) diabetes duration, systolic BP, BMI, smoking and triglycerides... (More)
A prospective study of normoalbutninuric diabetic patients was performed between 1997 and 2002 on 4097 type 1 and 6513 type 2 diabetic patients from the Swedish National Diabetes Register (NDR); mean study period, 4.6 years. The strongest independent baseline risk factors for the development of microalbuminuria (20-200 mug/min) were elevated HbA(1c) and diabetes duration in both types 1 and 2 diabetic patients. Other risk factors were high BMI, elevated systolic and diastolic BP in type 2 patients, and antihypertensive therapy in type 1 patients. A subsequent larger cross-sectional study in 2002 showed that established microalbummuria was independently associated with HbA(1c) diabetes duration, systolic BP, BMI, smoking and triglycerides in types 1 and 2 diabetic patients, and also with HDL-cholesterol in type 2 patients. Relatively few types 1 and 2 patients with microalbummuria achieved treatment targets of HbA(1c) < 6.5% (21-48%), BP < 130/85 mmHg (33-13%), cholesterol < 5 mmol/l (48-46%), triglycerides < 1.7 mmol/l (8348%) and BMI < 25 kg/m(2) (50-18%), respectively. In conclusion, high HbA(1c), BP and BMI were independent risk factors for the development of microalbuminuria in types 1 and 2 diabetic patients. These risk factors as well as triglycerides, HDL-cholesterol and smoking were independently associated with established microalbuminuria. Treatment targets were achieved by a relatively few patients with microalbuminuria. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diabetes, register, microalbuminuria, hypertension, body mass index
in
Diabetes Research and Clinical Practice
volume
67
issue
3
pages
258 - 266
publisher
Elsevier
external identifiers
  • wos:000227425700010
  • pmid:15713359
  • scopus:13844275224
ISSN
1872-8227
DOI
10.1016/j.diabres.2004.07.021
language
English
LU publication?
yes
id
8d0706a8-bcc1-4550-b840-1167347a8dc8 (old id 897177)
date added to LUP
2008-01-11 13:39:44
date last changed
2017-11-12 03:18:38
@article{8d0706a8-bcc1-4550-b840-1167347a8dc8,
  abstract     = {A prospective study of normoalbutninuric diabetic patients was performed between 1997 and 2002 on 4097 type 1 and 6513 type 2 diabetic patients from the Swedish National Diabetes Register (NDR); mean study period, 4.6 years. The strongest independent baseline risk factors for the development of microalbuminuria (20-200 mug/min) were elevated HbA(1c) and diabetes duration in both types 1 and 2 diabetic patients. Other risk factors were high BMI, elevated systolic and diastolic BP in type 2 patients, and antihypertensive therapy in type 1 patients. A subsequent larger cross-sectional study in 2002 showed that established microalbummuria was independently associated with HbA(1c) diabetes duration, systolic BP, BMI, smoking and triglycerides in types 1 and 2 diabetic patients, and also with HDL-cholesterol in type 2 patients. Relatively few types 1 and 2 patients with microalbummuria achieved treatment targets of HbA(1c) &lt; 6.5% (21-48%), BP &lt; 130/85 mmHg (33-13%), cholesterol &lt; 5 mmol/l (48-46%), triglycerides &lt; 1.7 mmol/l (8348%) and BMI &lt; 25 kg/m(2) (50-18%), respectively. In conclusion, high HbA(1c), BP and BMI were independent risk factors for the development of microalbuminuria in types 1 and 2 diabetic patients. These risk factors as well as triglycerides, HDL-cholesterol and smoking were independently associated with established microalbuminuria. Treatment targets were achieved by a relatively few patients with microalbuminuria.},
  author       = {Cederholm, J and Eliasson, B and Nilsson, Peter and Weiss, L and Gudbjornsdottir, S},
  issn         = {1872-8227},
  keyword      = {diabetes,register,microalbuminuria,hypertension,body mass index},
  language     = {eng},
  number       = {3},
  pages        = {258--266},
  publisher    = {Elsevier},
  series       = {Diabetes Research and Clinical Practice},
  title        = {Microalbuminuria and risk factors in type 1 and type 2 diabetic patients},
  url          = {http://dx.doi.org/10.1016/j.diabres.2004.07.021},
  volume       = {67},
  year         = {2005},
}