Recent findings shed light on the aetiopathogenesis of Sjogren's syndrome
(2005) In Aktuelle Rheumatologie 30(1). p.23-26- Abstract
- The systemic clinical picture of SS patients can be traced back to a disposition of many cell types to over-react when confronted with stress stimuli. This will influence basic cellular processes such as apoptosis and acetylcholine receptor signaling. This tissue hyper-reactivity may also explain the observed autoimmune features, and may constitute a major aetiopathogenetic determinant in SS.
- Abstract (Swedish)
- Abstract in German
Das systemische klinische Bild der Patienten mit SS kann auf eine Disposition vieler Zellarten zurückgeführt werden, bei einer Konfrontation mit Stressreizen überzureagieren. Dies beeinflusst die elementaren zellulären Vorgänge wie Apoptose und Acethylcholine-Rezeptor-Signalvermittlung. Diese Hyperreaktivität des Gewebes kann auch die beobachteten autoimmunogenen Eigenschaften erklären und könnte eine ätiopathogenetische Determinante beim SS darstellen.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/897364
- author
- Bredberg, Anders LU ; Manthorpe, Rolf LU and Henriksson, Gunnel LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Stressreaktion, Antigen präsentierende Zellen, Acetylcholin, Sjogren's syndrome, stress response, acetylcholine, antigen-presenting cells
- in
- Aktuelle Rheumatologie
- volume
- 30
- issue
- 1
- pages
- 23 - 26
- publisher
- Georg Thieme Verlag
- external identifiers
-
- wos:000227396800003
- scopus:14744277359
- ISSN
- 0341-051X
- DOI
- 10.1055/s-2005-857987
- language
- English
- LU publication?
- yes
- id
- 788e4336-8f55-4335-b959-9dae3becc5c3 (old id 897364)
- date added to LUP
- 2016-04-01 11:38:15
- date last changed
- 2022-01-26 07:59:56
@article{788e4336-8f55-4335-b959-9dae3becc5c3, abstract = {{The systemic clinical picture of SS patients can be traced back to a disposition of many cell types to over-react when confronted with stress stimuli. This will influence basic cellular processes such as apoptosis and acetylcholine receptor signaling. This tissue hyper-reactivity may also explain the observed autoimmune features, and may constitute a major aetiopathogenetic determinant in SS.}}, author = {{Bredberg, Anders and Manthorpe, Rolf and Henriksson, Gunnel}}, issn = {{0341-051X}}, keywords = {{Stressreaktion; Antigen präsentierende Zellen; Acetylcholin; Sjogren's syndrome; stress response; acetylcholine; antigen-presenting cells}}, language = {{eng}}, number = {{1}}, pages = {{23--26}}, publisher = {{Georg Thieme Verlag}}, series = {{Aktuelle Rheumatologie}}, title = {{Recent findings shed light on the aetiopathogenesis of Sjogren's syndrome}}, url = {{http://dx.doi.org/10.1055/s-2005-857987}}, doi = {{10.1055/s-2005-857987}}, volume = {{30}}, year = {{2005}}, }