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Recent findings shed light on the aetiopathogenesis of Sjogren's syndrome

Bredberg, Anders LU ; Manthorpe, Rolf LU and Henriksson, Gunnel LU (2005) In Aktuelle Rheumatologie 30(1). p.23-26
Abstract (Swedish)
Abstract in German

Das systemische klinische Bild der Patienten mit SS kann auf eine Disposition vieler Zellarten zurückgeführt werden, bei einer Konfrontation mit Stressreizen überzureagieren. Dies beeinflusst die elementaren zellulären Vorgänge wie Apoptose und Acethylcholine-Rezeptor-Signalvermittlung. Diese Hyperreaktivität des Gewebes kann auch die beobachteten autoimmunogenen Eigenschaften erklären und könnte eine ätiopathogenetische Determinante beim SS darstellen.
Abstract
The systemic clinical picture of SS patients can be traced back to a disposition of many cell types to over-react when confronted with stress stimuli. This will influence basic cellular processes such as apoptosis and acetylcholine receptor signaling. This tissue hyper-reactivity may also explain the observed autoimmune features, and may constitute a major aetiopathogenetic determinant in SS.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Stressreaktion, Antigen präsentierende Zellen, Acetylcholin, Sjogren's syndrome, stress response, acetylcholine, antigen-presenting cells
in
Aktuelle Rheumatologie
volume
30
issue
1
pages
23 - 26
publisher
Georg Thieme Verlag
external identifiers
  • wos:000227396800003
  • scopus:14744277359
ISSN
0341-051X
DOI
10.1055/s-2005-857987
language
English
LU publication?
yes
id
788e4336-8f55-4335-b959-9dae3becc5c3 (old id 897364)
date added to LUP
2008-01-11 12:18:48
date last changed
2017-09-03 03:36:53
@article{788e4336-8f55-4335-b959-9dae3becc5c3,
  abstract     = {The systemic clinical picture of SS patients can be traced back to a disposition of many cell types to over-react when confronted with stress stimuli. This will influence basic cellular processes such as apoptosis and acetylcholine receptor signaling. This tissue hyper-reactivity may also explain the observed autoimmune features, and may constitute a major aetiopathogenetic determinant in SS.},
  author       = {Bredberg, Anders and Manthorpe, Rolf and Henriksson, Gunnel},
  issn         = {0341-051X},
  keyword      = {Stressreaktion,Antigen präsentierende Zellen,Acetylcholin,Sjogren's syndrome,stress response,acetylcholine,antigen-presenting cells},
  language     = {eng},
  number       = {1},
  pages        = {23--26},
  publisher    = {Georg Thieme Verlag},
  series       = {Aktuelle Rheumatologie},
  title        = {Recent findings shed light on the aetiopathogenesis of Sjogren's syndrome},
  url          = {http://dx.doi.org/10.1055/s-2005-857987},
  volume       = {30},
  year         = {2005},
}