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Patch testing with methyldibromo glutaronitrile, a multicentre study within the EECDRG

Gruvberger, Birgitta LU ; Andersen, KE; Brandao, FM; Bruynzeel, DP; Bruze, Magnus LU ; Frosch, PJ; Goossens, A; Lahti, A; Lindberg, M and Menne, T, et al. (2005) In Contact Dermatitis 52(1). p.14-18
Abstract
Contact allergy to and allergic contact dermatitis from methyldibromo glutaronitrile (MDBGN) have frequently been reported. As there has been no agreement on which MDBGN test preparation to use, a study was initiated to help determine the optimal patch test preparation for MDBGN. 2661 consecutively patch tested patients at 11 test clinics representing 9 European countries participated. Petrolatum preparations with MDBGN at 1.0%, 0.5%, 0.3% and 0.1% were inserted in the standard series. Contact allergy rates were noted in the range 4.4-1.1% following decreasing test concentrations. Reactions not fulfilling all criteria to be classified as allergic reactions could represent either weak allergic or irritant reactions, and such reactions were... (More)
Contact allergy to and allergic contact dermatitis from methyldibromo glutaronitrile (MDBGN) have frequently been reported. As there has been no agreement on which MDBGN test preparation to use, a study was initiated to help determine the optimal patch test preparation for MDBGN. 2661 consecutively patch tested patients at 11 test clinics representing 9 European countries participated. Petrolatum preparations with MDBGN at 1.0%, 0.5%, 0.3% and 0.1% were inserted in the standard series. Contact allergy rates were noted in the range 4.4-1.1% following decreasing test concentrations. Reactions not fulfilling all criteria to be classified as allergic reactions could represent either weak allergic or irritant reactions, and such reactions were noted in the range 8.2-0.5% with decreasing concentrations. A significant number of these reactions represented weak allergic reactions, as allergic reactions were obtained to higher patch test concentrations in the same individual. Morphologically irritant reactions were noted only for the highest test concentrations. In summary, the contact allergy rates and frequencies of doubtful and irritant reactions vary with the patch test concentration. The final decision on patch test concentration for MDBGN should not only rely on these factors but also include information on patch test concentrations required to diagnose individual cases with allergic contact dermatitis from MDBGN as well as results of repeated open application tests. (Less)
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keywords
Tektamer 38, preservative, methyldibromo glutaronitrile, Euxyl K400, series, European standard test, contact allergy, CAS 35691-65-7, dermatitis, allergic contact, 4-dicyanobutane, 2-dibromo-2, 1, adverse reactions
in
Contact Dermatitis
volume
52
issue
1
pages
14 - 18
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:15701124
  • wos:000226899300007
  • scopus:20044366176
ISSN
0105-1873
DOI
10.1111/j.0105-1873.2005.00480.x
language
English
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yes
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dbbda7f8-95c2-4c60-8b0f-ed1364706b3a (old id 897473)
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2008-01-16 09:46:06
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2017-10-22 03:42:53
@article{dbbda7f8-95c2-4c60-8b0f-ed1364706b3a,
  abstract     = {Contact allergy to and allergic contact dermatitis from methyldibromo glutaronitrile (MDBGN) have frequently been reported. As there has been no agreement on which MDBGN test preparation to use, a study was initiated to help determine the optimal patch test preparation for MDBGN. 2661 consecutively patch tested patients at 11 test clinics representing 9 European countries participated. Petrolatum preparations with MDBGN at 1.0%, 0.5%, 0.3% and 0.1% were inserted in the standard series. Contact allergy rates were noted in the range 4.4-1.1% following decreasing test concentrations. Reactions not fulfilling all criteria to be classified as allergic reactions could represent either weak allergic or irritant reactions, and such reactions were noted in the range 8.2-0.5% with decreasing concentrations. A significant number of these reactions represented weak allergic reactions, as allergic reactions were obtained to higher patch test concentrations in the same individual. Morphologically irritant reactions were noted only for the highest test concentrations. In summary, the contact allergy rates and frequencies of doubtful and irritant reactions vary with the patch test concentration. The final decision on patch test concentration for MDBGN should not only rely on these factors but also include information on patch test concentrations required to diagnose individual cases with allergic contact dermatitis from MDBGN as well as results of repeated open application tests.},
  author       = {Gruvberger, Birgitta and Andersen, KE and Brandao, FM and Bruynzeel, DP and Bruze, Magnus and Frosch, PJ and Goossens, A and Lahti, A and Lindberg, M and Menne, T and Orton, D and Seidenari, S},
  issn         = {0105-1873},
  keyword      = {Tektamer 38,preservative,methyldibromo glutaronitrile,Euxyl K400,series,European standard test,contact allergy,CAS 35691-65-7,dermatitis,allergic contact,4-dicyanobutane,2-dibromo-2,1,adverse reactions},
  language     = {eng},
  number       = {1},
  pages        = {14--18},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Patch testing with methyldibromo glutaronitrile, a multicentre study within the EECDRG},
  url          = {http://dx.doi.org/10.1111/j.0105-1873.2005.00480.x},
  volume       = {52},
  year         = {2005},
}