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Factors associated with development of stroke long-term after myocardial infarction: experiences from the LoWASA trial

Herlitz, J ; Holm, Johan LU ; Peterson, M ; Karlson, BW ; Evander, MH and Erhardt, Leif RW LU (2005) In Journal of Internal Medicine 257(2). p.201-207
Abstract
Objective. To describe factors associated with the development of stroke during long-term follow-up after acute myocardial infarction (AMI) in the LoWASA trial. Patients. Patients who had been hospitalized for AMI were randomized within 42 days to receive either warfarin 1.25 mg plus aspirin 75 mg daily or aspirin 75 mg alone. Design. The study was performed according to the probe design, that is open treatment and blinded end-point evaluation. Setting. The study was performed in 31 hospitals in Sweden. The mean follow-up time was 5.0 years with a range of 1.7-6.7 years. Results. In all, 3300 patients were randomized in the trial, of which 194 (5.9%) developed stroke (4.2% nonhaemorrhagic, 0.5% haemorrhagic and 1.3% uncertain. The... (More)
Objective. To describe factors associated with the development of stroke during long-term follow-up after acute myocardial infarction (AMI) in the LoWASA trial. Patients. Patients who had been hospitalized for AMI were randomized within 42 days to receive either warfarin 1.25 mg plus aspirin 75 mg daily or aspirin 75 mg alone. Design. The study was performed according to the probe design, that is open treatment and blinded end-point evaluation. Setting. The study was performed in 31 hospitals in Sweden. The mean follow-up time was 5.0 years with a range of 1.7-6.7 years. Results. In all, 3300 patients were randomized in the trial, of which 194 (5.9%) developed stroke (4.2% nonhaemorrhagic, 0.5% haemorrhagic and 1.3% uncertain. The following factors appeared as independent predictors for an increased risk of stroke: age, hazard ratio and 95% confidence interval (1.07; 1.05-1.08), a history of diabetes mellitus (2.4; 1.8-3.4), a history of stroke (2.3; 1.5-3.5), a history of hypertension (2.0; 1.5-2.7) and a history of smoking (1.5;1.1-2.0). Most of these factors were also predictors of a nonhaemorrhagic stroke whereas no predictor of haemorrhagic stroke was found. Conclusion. Risk indicators for stroke long-term after AMI were increasing age, a history of either diabetes mellitus, stroke, hypertension or smoking. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acute myocardial infarction, stroke
in
Journal of Internal Medicine
volume
257
issue
2
pages
201 - 207
publisher
Wiley-Blackwell
external identifiers
  • pmid:15656879
  • wos:000226458200009
  • scopus:13244287974
  • pmid:15656879
ISSN
1365-2796
DOI
10.1111/j.1365-2796.2004.01433.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Internal Medicine Research Unit (013242520)
id
beb25a8c-c80d-469c-bd07-e27880115f40 (old id 897627)
date added to LUP
2016-04-01 15:46:39
date last changed
2021-01-06 02:51:45
@article{beb25a8c-c80d-469c-bd07-e27880115f40,
  abstract     = {Objective. To describe factors associated with the development of stroke during long-term follow-up after acute myocardial infarction (AMI) in the LoWASA trial. Patients. Patients who had been hospitalized for AMI were randomized within 42 days to receive either warfarin 1.25 mg plus aspirin 75 mg daily or aspirin 75 mg alone. Design. The study was performed according to the probe design, that is open treatment and blinded end-point evaluation. Setting. The study was performed in 31 hospitals in Sweden. The mean follow-up time was 5.0 years with a range of 1.7-6.7 years. Results. In all, 3300 patients were randomized in the trial, of which 194 (5.9%) developed stroke (4.2% nonhaemorrhagic, 0.5% haemorrhagic and 1.3% uncertain. The following factors appeared as independent predictors for an increased risk of stroke: age, hazard ratio and 95% confidence interval (1.07; 1.05-1.08), a history of diabetes mellitus (2.4; 1.8-3.4), a history of stroke (2.3; 1.5-3.5), a history of hypertension (2.0; 1.5-2.7) and a history of smoking (1.5;1.1-2.0). Most of these factors were also predictors of a nonhaemorrhagic stroke whereas no predictor of haemorrhagic stroke was found. Conclusion. Risk indicators for stroke long-term after AMI were increasing age, a history of either diabetes mellitus, stroke, hypertension or smoking.},
  author       = {Herlitz, J and Holm, Johan and Peterson, M and Karlson, BW and Evander, MH and Erhardt, Leif RW},
  issn         = {1365-2796},
  language     = {eng},
  number       = {2},
  pages        = {201--207},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Internal Medicine},
  title        = {Factors associated with development of stroke long-term after myocardial infarction: experiences from the LoWASA trial},
  url          = {http://dx.doi.org/10.1111/j.1365-2796.2004.01433.x},
  doi          = {10.1111/j.1365-2796.2004.01433.x},
  volume       = {257},
  year         = {2005},
}