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Contact allergy to isoeugenol and its derivatives: problems with allergen substitution

Tanaka, S; Royds, C; Buckley, D; Basketter, DA; Goossens, A; Bruze, Magnus LU ; Svedman, Cecilia LU ; Menne, T; Johansen, JD and White, IR, et al. (2004) In Contact Dermatitis 51(5-6). p.288-291
Abstract
A total of 2261 (808 male, 1453 female) consecutive patients attending contact dermatitis clinics were patch tested to isoeugenol and its derivatives listed in the EU Inventory of Fragrance Ingredients. Positive reactions were found to isoeugenol in 40, transisoeugenol in 40, isoeugenyl acetate in 19, isoeugenyl benzoate in 4, isoeugenyl phenylacetate in 16, isoeugenyl methyl ether in 6 and benzyl isoeugenyl ether in 2 patients. There was a concomitant reaction to isoeugenol in 36/40 of those positive to transisoeugenol, 13/19 of those to isoeugenyl acetate, 3/4 of those to isoeugenyl benzoate and 15/16 of those to isoeugenyl phenylacetate but in none of those 6 positive to isoeugenyl methyl ether and in neither of those 2 positive to... (More)
A total of 2261 (808 male, 1453 female) consecutive patients attending contact dermatitis clinics were patch tested to isoeugenol and its derivatives listed in the EU Inventory of Fragrance Ingredients. Positive reactions were found to isoeugenol in 40, transisoeugenol in 40, isoeugenyl acetate in 19, isoeugenyl benzoate in 4, isoeugenyl phenylacetate in 16, isoeugenyl methyl ether in 6 and benzyl isoeugenyl ether in 2 patients. There was a concomitant reaction to isoeugenol in 36/40 of those positive to transisoeugenol, 13/19 of those to isoeugenyl acetate, 3/4 of those to isoeugenyl benzoate and 15/16 of those to isoeugenyl phenylacetate but in none of those 6 positive to isoeugenyl methyl ether and in neither of those 2 positive to benzyl isoeugenyl ether. Concomitant contact allergy between isoeugenol and its derivatives may occur through chemical cross-reactivity or local skin metabolism of the derivatives. It is more commonly observed with the esters rather than the ethers. Isoeugenyl acetate has been proposed as an alternative to isoeugenol, but there is a high degree of concomitant reactivity with isoeugenol. (Less)
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type
Contribution to journal
publication status
published
subject
keywords
skin, metabolism, isoeugenol, derivatives, contact allergy, cross-reactivity
in
Contact Dermatitis
volume
51
issue
5-6
pages
288 - 291
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000225629900012
  • scopus:19944370081
ISSN
0105-1873
DOI
10.1111/j.0105-1873.2004.00446.x
language
English
LU publication?
yes
id
2c6e19be-5ed4-44b7-97a1-5c91496d84e1 (old id 897769)
date added to LUP
2008-01-18 13:50:17
date last changed
2017-10-01 03:36:06
@article{2c6e19be-5ed4-44b7-97a1-5c91496d84e1,
  abstract     = {A total of 2261 (808 male, 1453 female) consecutive patients attending contact dermatitis clinics were patch tested to isoeugenol and its derivatives listed in the EU Inventory of Fragrance Ingredients. Positive reactions were found to isoeugenol in 40, transisoeugenol in 40, isoeugenyl acetate in 19, isoeugenyl benzoate in 4, isoeugenyl phenylacetate in 16, isoeugenyl methyl ether in 6 and benzyl isoeugenyl ether in 2 patients. There was a concomitant reaction to isoeugenol in 36/40 of those positive to transisoeugenol, 13/19 of those to isoeugenyl acetate, 3/4 of those to isoeugenyl benzoate and 15/16 of those to isoeugenyl phenylacetate but in none of those 6 positive to isoeugenyl methyl ether and in neither of those 2 positive to benzyl isoeugenyl ether. Concomitant contact allergy between isoeugenol and its derivatives may occur through chemical cross-reactivity or local skin metabolism of the derivatives. It is more commonly observed with the esters rather than the ethers. Isoeugenyl acetate has been proposed as an alternative to isoeugenol, but there is a high degree of concomitant reactivity with isoeugenol.},
  author       = {Tanaka, S and Royds, C and Buckley, D and Basketter, DA and Goossens, A and Bruze, Magnus and Svedman, Cecilia and Menne, T and Johansen, JD and White, IR and McFadden, JP},
  issn         = {0105-1873},
  keyword      = {skin,metabolism,isoeugenol,derivatives,contact allergy,cross-reactivity},
  language     = {eng},
  number       = {5-6},
  pages        = {288--291},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Contact allergy to isoeugenol and its derivatives: problems with allergen substitution},
  url          = {http://dx.doi.org/10.1111/j.0105-1873.2004.00446.x},
  volume       = {51},
  year         = {2004},
}