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Silvanus Thompson Memorial Lecture Molecular imaging using hyperpolarized C-13

Golman, Klaes LU ; Olsson, Lars E LU ; Axelsson, O; Månsson, Sven LU ; Karlsson, M and Petersson, J S LU (2003) In British Journal of Radiology 76 (Spec No 2). p.118-127
Abstract
MRI provides unsurpassed soft tissue contrast, but the inherent low sensitivity of this modality has limited the clinical use to imaging of water protons. With hyperpolarization techniques, the signal from a given number of nuclear spins can be raised more than 100 000 times. The strong signal enhancement enables imaging of nuclei other than protons, e.g. C-13 and N-15, and their molecular distribution in vivo can be visualized in a clinically relevant time window. This article reviews different hyperpolarization techniques and some of the many application areas. As an example, experiments are presented where hyperpolarized C-13 nuclei have been injected into rabbits, followed by rapid C-13 MRI with high spatial resolution (scan time <1... (More)
MRI provides unsurpassed soft tissue contrast, but the inherent low sensitivity of this modality has limited the clinical use to imaging of water protons. With hyperpolarization techniques, the signal from a given number of nuclear spins can be raised more than 100 000 times. The strong signal enhancement enables imaging of nuclei other than protons, e.g. C-13 and N-15, and their molecular distribution in vivo can be visualized in a clinically relevant time window. This article reviews different hyperpolarization techniques and some of the many application areas. As an example, experiments are presented where hyperpolarized C-13 nuclei have been injected into rabbits, followed by rapid C-13 MRI with high spatial resolution (scan time <1 s and 1.0 mm in-plane resolution). The high degree of polarization thus enabled mapping of the molecular distribution within various organs, a few seconds after injection. The hyperpolarized C-13 MRI technique allows a selective identification of the molecules that give rise to the MR signal, offering direct molecular imaging. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Carbon Isotopes, Humans, Lung Diseases, Magnetic Resonance Imaging, Male, Models, Chemical, Rabbits, Thermodynamics
in
British Journal of Radiology
volume
76
issue
Spec No 2
pages
118 - 127
publisher
British Inst Radiology
external identifiers
  • wos:000225157000004
  • scopus:8844271662
ISSN
1748-880X
DOI
10.1259/bjr/26631666http://dx.doi.org/10.1259/bjr/26631666
language
English
LU publication?
no
id
541dd130-9ec7-4899-aba2-c7c45cc360a8 (old id 897944)
alternative location
http://bjr.birjournals.org/cgi/content/abstract/76/suppl_2/S118
date added to LUP
2008-01-11 14:44:47
date last changed
2018-01-21 03:57:02
@article{541dd130-9ec7-4899-aba2-c7c45cc360a8,
  abstract     = {MRI provides unsurpassed soft tissue contrast, but the inherent low sensitivity of this modality has limited the clinical use to imaging of water protons. With hyperpolarization techniques, the signal from a given number of nuclear spins can be raised more than 100 000 times. The strong signal enhancement enables imaging of nuclei other than protons, e.g. C-13 and N-15, and their molecular distribution in vivo can be visualized in a clinically relevant time window. This article reviews different hyperpolarization techniques and some of the many application areas. As an example, experiments are presented where hyperpolarized C-13 nuclei have been injected into rabbits, followed by rapid C-13 MRI with high spatial resolution (scan time &lt;1 s and 1.0 mm in-plane resolution). The high degree of polarization thus enabled mapping of the molecular distribution within various organs, a few seconds after injection. The hyperpolarized C-13 MRI technique allows a selective identification of the molecules that give rise to the MR signal, offering direct molecular imaging.},
  author       = {Golman, Klaes and Olsson, Lars E and Axelsson, O and Månsson, Sven and Karlsson, M and Petersson, J S},
  issn         = {1748-880X},
  keyword      = {Animals,Carbon Isotopes,Humans,Lung Diseases,Magnetic Resonance Imaging,Male,Models, Chemical,Rabbits,Thermodynamics},
  language     = {eng},
  number       = {Spec No 2},
  pages        = {118--127},
  publisher    = {British Inst Radiology},
  series       = {British Journal of Radiology},
  title        = {Silvanus Thompson Memorial Lecture Molecular imaging using hyperpolarized C-13},
  url          = {http://dx.doi.org/10.1259/bjr/26631666http://dx.doi.org/10.1259/bjr/26631666},
  volume       = {76 },
  year         = {2003},
}