Advanced

Immune response in burn patients in relation to HIV infection and sepsis

Sjoberg, T; Mzezewa, S; Jonsson, K and Salemark, Lars LU (2004) In Burns 30(7). p.670-674
Abstract
The post-burn immune dysfunction predisposes patients to sepsis and multiple organ failure leading to increased mortality. HIV infection also results in a depressed immune response. The combination of burn injury and HIV might therefore lead to an increased morbidity and mortality as compared to non-HIV infected burn patients. Twenty burn patients and 10 healthy volunteers were included in a prospective study. To evaluate their immune status, CD4+ and CD8+ T-lymphocyte counts were determined in peripheral blood. HIV serology samples were obtained on admission. Bacteriological cultures were obtained from wound surface samples and wound tissue biopsies. Six burn patients were HIV infected. Clinical signs of sepsis were observed in 10... (More)
The post-burn immune dysfunction predisposes patients to sepsis and multiple organ failure leading to increased mortality. HIV infection also results in a depressed immune response. The combination of burn injury and HIV might therefore lead to an increased morbidity and mortality as compared to non-HIV infected burn patients. Twenty burn patients and 10 healthy volunteers were included in a prospective study. To evaluate their immune status, CD4+ and CD8+ T-lymphocyte counts were determined in peripheral blood. HIV serology samples were obtained on admission. Bacteriological cultures were obtained from wound surface samples and wound tissue biopsies. Six burn patients were HIV infected. Clinical signs of sepsis were observed in 10 patients. The number of CD4+ T-lymphocytes were lower in burn patients compared to healthy volunteers (P < 0.05). HIV infected burn patients had lower CD4+ lymphocyte counts than non-HIV infected patients (P < 0.05). Patients with clinical signs of sepsis had lower CD4+ counts compared to patients without sepsis (P < 0.05). There was no difference in the mortality rate or the length of hospitalisation between patient groups. burn injury, HIV infection and sepsis independently result in immunosuppression. (C) 2004 Elsevier Ltd and ISBI. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
burns, wound infection, HIV infection, sepsis, immunosuppression
in
Burns
volume
30
issue
7
pages
670 - 674
publisher
Elsevier
external identifiers
  • wos:000224715700008
  • scopus:4744359025
ISSN
0305-4179
DOI
10.1016/j.burns.2004.03.014
language
English
LU publication?
yes
id
a00ef492-a6ec-4ea9-b918-ae1581736932 (old id 898004)
date added to LUP
2008-01-18 12:31:41
date last changed
2017-01-15 03:38:42
@article{a00ef492-a6ec-4ea9-b918-ae1581736932,
  abstract     = {The post-burn immune dysfunction predisposes patients to sepsis and multiple organ failure leading to increased mortality. HIV infection also results in a depressed immune response. The combination of burn injury and HIV might therefore lead to an increased morbidity and mortality as compared to non-HIV infected burn patients. Twenty burn patients and 10 healthy volunteers were included in a prospective study. To evaluate their immune status, CD4+ and CD8+ T-lymphocyte counts were determined in peripheral blood. HIV serology samples were obtained on admission. Bacteriological cultures were obtained from wound surface samples and wound tissue biopsies. Six burn patients were HIV infected. Clinical signs of sepsis were observed in 10 patients. The number of CD4+ T-lymphocytes were lower in burn patients compared to healthy volunteers (P &lt; 0.05). HIV infected burn patients had lower CD4+ lymphocyte counts than non-HIV infected patients (P &lt; 0.05). Patients with clinical signs of sepsis had lower CD4+ counts compared to patients without sepsis (P &lt; 0.05). There was no difference in the mortality rate or the length of hospitalisation between patient groups. burn injury, HIV infection and sepsis independently result in immunosuppression. (C) 2004 Elsevier Ltd and ISBI. All rights reserved.},
  author       = {Sjoberg, T and Mzezewa, S and Jonsson, K and Salemark, Lars},
  issn         = {0305-4179},
  keyword      = {burns,wound infection,HIV infection,sepsis,immunosuppression},
  language     = {eng},
  number       = {7},
  pages        = {670--674},
  publisher    = {Elsevier},
  series       = {Burns},
  title        = {Immune response in burn patients in relation to HIV infection and sepsis},
  url          = {http://dx.doi.org/10.1016/j.burns.2004.03.014},
  volume       = {30},
  year         = {2004},
}