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Late neonatal lupus erythematosus onset in a child born of a mother with primary Sjogren's syndrome

Manthorpe, Rolf LU ; Svensson, Åke LU and Wirestrand, LE (2004) In Annals of the Rheumatic Diseases 63(11). p.1496-1497
Abstract
Background: The neonatal lupus syndrome can be present as congenital heart block (CHB) or as neonatal lupus erythematosus (NLE), both seldom passively acquired autoimmune diseases. CHB starts around week 20 of pregnancy and is a lifelong event, whereas NLE is self limiting and usually starts at the 6th week of the child's age - the maximum recorded up to week 20. Case report: An asymptomatic mother with primary Sjogren's syndrome and anti-SSA/Ro52, anti-SSA/Ro60, and anti-SSB/La autoantibodies is described who, at gestational week 23 during her first pregnancy, was diagnosed as having a male fetus with CHB due to third degree atrioventricular block. The boy from the second pregnancy developed skin eruptions which clinically and by biopsy... (More)
Background: The neonatal lupus syndrome can be present as congenital heart block (CHB) or as neonatal lupus erythematosus (NLE), both seldom passively acquired autoimmune diseases. CHB starts around week 20 of pregnancy and is a lifelong event, whereas NLE is self limiting and usually starts at the 6th week of the child's age - the maximum recorded up to week 20. Case report: An asymptomatic mother with primary Sjogren's syndrome and anti-SSA/Ro52, anti-SSA/Ro60, and anti-SSB/La autoantibodies is described who, at gestational week 23 during her first pregnancy, was diagnosed as having a male fetus with CHB due to third degree atrioventricular block. The boy from the second pregnancy developed skin eruptions which clinically and by biopsy were compatible with NLE at week 20+1 post partum. Conclusions: Our case of NLE, starting at week 20+1 of age, seems to be the latest reported clinical case of NLE. Development of CHB and NLE in two consecutive boy pregnancies is unusual. (Less)
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author
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publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
63
issue
11
pages
1496 - 1497
publisher
BMJ Publishing Group
external identifiers
  • wos:000224412800023
  • pmid:15479901
  • scopus:7244252965
ISSN
1468-2060
DOI
10.1136/ard.2003.014944
language
English
LU publication?
yes
id
457037c6-10d8-477e-96ab-fbdbc345f339 (old id 898152)
date added to LUP
2016-04-01 16:04:22
date last changed
2022-01-28 17:06:17
@article{457037c6-10d8-477e-96ab-fbdbc345f339,
  abstract     = {{Background: The neonatal lupus syndrome can be present as congenital heart block (CHB) or as neonatal lupus erythematosus (NLE), both seldom passively acquired autoimmune diseases. CHB starts around week 20 of pregnancy and is a lifelong event, whereas NLE is self limiting and usually starts at the 6th week of the child's age - the maximum recorded up to week 20. Case report: An asymptomatic mother with primary Sjogren's syndrome and anti-SSA/Ro52, anti-SSA/Ro60, and anti-SSB/La autoantibodies is described who, at gestational week 23 during her first pregnancy, was diagnosed as having a male fetus with CHB due to third degree atrioventricular block. The boy from the second pregnancy developed skin eruptions which clinically and by biopsy were compatible with NLE at week 20+1 post partum. Conclusions: Our case of NLE, starting at week 20+1 of age, seems to be the latest reported clinical case of NLE. Development of CHB and NLE in two consecutive boy pregnancies is unusual.}},
  author       = {{Manthorpe, Rolf and Svensson, Åke and Wirestrand, LE}},
  issn         = {{1468-2060}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1496--1497}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{Annals of the Rheumatic Diseases}},
  title        = {{Late neonatal lupus erythematosus onset in a child born of a mother with primary Sjogren's syndrome}},
  url          = {{http://dx.doi.org/10.1136/ard.2003.014944}},
  doi          = {{10.1136/ard.2003.014944}},
  volume       = {{63}},
  year         = {{2004}},
}