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Persistent itching nodules after the fourth dose of diphtheria-tetanus toxoid vaccines without evidence of delayed hypersensitivity to aluminium

Netterlid, E; Bruze, A; Hindsen, A; Isaksson, Marléne LU and Olin, P (2004) In Vaccine 22(27-28). p.3698-3706
Abstract
Studies in Gothenburg, Sweden, reported an exceptionally high rate of persistent itching nodules at the site of injection of aluminium containing vaccines, usually with positive epicutaneous tests to aluminium. When a new booster diphtheria-tetanus vaccine was introduced we performed a prospective cluster randomised active surveillance in 25,232 10-year-olds. Parental reports 6 months after vaccination with Duplex(R) or diTeBooster(R) were collected for 22,365 (88%) pupils in 851 schools. We identified 3-6 children per 10,000 with a local itching nodule persisting for at least 2 months. There were no significant differences between the vaccine groups. Contact allergy to aluminium was not detected. The findings support the use of the... (More)
Studies in Gothenburg, Sweden, reported an exceptionally high rate of persistent itching nodules at the site of injection of aluminium containing vaccines, usually with positive epicutaneous tests to aluminium. When a new booster diphtheria-tetanus vaccine was introduced we performed a prospective cluster randomised active surveillance in 25,232 10-year-olds. Parental reports 6 months after vaccination with Duplex(R) or diTeBooster(R) were collected for 22,365 (88%) pupils in 851 schools. We identified 3-6 children per 10,000 with a local itching nodule persisting for at least 2 months. There were no significant differences between the vaccine groups. Contact allergy to aluminium was not detected. The findings support the use of the vaccine presently available in the Swedish vaccination program. Continued surveillance of persistent itching nodules and aluminium contact allergy is, however, warranted for vaccines containing pertussis toxoid and aluminium. (C) 2004 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DT-vaccine booster, allergy, persistent local reactions, aluminium contact
in
Vaccine
volume
22
issue
27-28
pages
3698 - 3706
publisher
Elsevier
external identifiers
  • wos:000223815100019
  • pmid:15315849
  • scopus:4143069191
ISSN
1873-2518
DOI
10.1016/j.vaccine.2004.03.036
language
English
LU publication?
yes
id
213ea2b9-f6e6-4c41-8bb6-43619529b815 (old id 898410)
date added to LUP
2008-01-15 15:26:49
date last changed
2017-09-10 03:49:59
@article{213ea2b9-f6e6-4c41-8bb6-43619529b815,
  abstract     = {Studies in Gothenburg, Sweden, reported an exceptionally high rate of persistent itching nodules at the site of injection of aluminium containing vaccines, usually with positive epicutaneous tests to aluminium. When a new booster diphtheria-tetanus vaccine was introduced we performed a prospective cluster randomised active surveillance in 25,232 10-year-olds. Parental reports 6 months after vaccination with Duplex(R) or diTeBooster(R) were collected for 22,365 (88%) pupils in 851 schools. We identified 3-6 children per 10,000 with a local itching nodule persisting for at least 2 months. There were no significant differences between the vaccine groups. Contact allergy to aluminium was not detected. The findings support the use of the vaccine presently available in the Swedish vaccination program. Continued surveillance of persistent itching nodules and aluminium contact allergy is, however, warranted for vaccines containing pertussis toxoid and aluminium. (C) 2004 Elsevier Ltd. All rights reserved.},
  author       = {Netterlid, E and Bruze, A and Hindsen, A and Isaksson, Marléne and Olin, P},
  issn         = {1873-2518},
  keyword      = {DT-vaccine booster,allergy,persistent local reactions,aluminium contact},
  language     = {eng},
  number       = {27-28},
  pages        = {3698--3706},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {Persistent itching nodules after the fourth dose of diphtheria-tetanus toxoid vaccines without evidence of delayed hypersensitivity to aluminium},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2004.03.036},
  volume       = {22},
  year         = {2004},
}