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The nerve fibre layer symmetry test: computerized evaluation of human retinal nerve fibre layer thickness as measured by optical coherence tomography

Hougaard, JL; Heijl, Anders LU and Krogh, E (2004) In Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00 82(4). p.410-418
Abstract
Purpose: To present and test a new interpretative concept, the nerve fibre layer symmetry test (NST), for computerized evaluation of retinal nerve fibre layer thickness (RNFLT) as measured by optical coherence tomography (OCT) in glaucoma. Methods: The NST concept was constructed and tested in a pilot study. A total of 32 healthy and 40 age-matched glaucomatous eyes were included and examined by OCT, computerized perimetry, RNFL/disc photography, tonometry and a general ophthalmologic examination. Results: The observed NST sensitivity and specificity were high, at 38/40 eyes (95%) and 32/32 eyes (100%), respectively, and 40/40 eyes (100%), and 31/32 eyes (97%), respectively, when correcting the OCT RNFLT measurement for the influence of... (More)
Purpose: To present and test a new interpretative concept, the nerve fibre layer symmetry test (NST), for computerized evaluation of retinal nerve fibre layer thickness (RNFLT) as measured by optical coherence tomography (OCT) in glaucoma. Methods: The NST concept was constructed and tested in a pilot study. A total of 32 healthy and 40 age-matched glaucomatous eyes were included and examined by OCT, computerized perimetry, RNFL/disc photography, tonometry and a general ophthalmologic examination. Results: The observed NST sensitivity and specificity were high, at 38/40 eyes (95%) and 32/32 eyes (100%), respectively, and 40/40 eyes (100%), and 31/32 eyes (97%), respectively, when correcting the OCT RNFLT measurement for the influence of variability in image signal/quality. The NST sensitivity was 8-10% higher than the single most sensitive traditional OCT RNFLT parameter; this difference was not statistically significant in this small sample. Conclusion: The NST showed high specificity and sensitivity for detection of RNFLT attenuation indicating early to severe glaucoma. Although promising, the NST needs to be further developed and validated in larger study samples and in patients with various stages of glaucomatous damage. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
automated analysis, optical coherence tomography, diagnosis, retinal nerve fibre layer, glaucoma
in
Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00
volume
82
issue
4
pages
410 - 418
publisher
Wiley-Blackwell
external identifiers
  • pmid:15291934
  • wos:000223473100008
  • scopus:4444370753
ISSN
1395-3907
DOI
10.1111/j.1395-3907.2004.00302.x
language
English
LU publication?
yes
id
9aa91c96-07cf-46c8-b0b3-3751a992e185 (old id 898558)
date added to LUP
2008-01-15 11:04:02
date last changed
2017-01-01 06:48:01
@article{9aa91c96-07cf-46c8-b0b3-3751a992e185,
  abstract     = {Purpose: To present and test a new interpretative concept, the nerve fibre layer symmetry test (NST), for computerized evaluation of retinal nerve fibre layer thickness (RNFLT) as measured by optical coherence tomography (OCT) in glaucoma. Methods: The NST concept was constructed and tested in a pilot study. A total of 32 healthy and 40 age-matched glaucomatous eyes were included and examined by OCT, computerized perimetry, RNFL/disc photography, tonometry and a general ophthalmologic examination. Results: The observed NST sensitivity and specificity were high, at 38/40 eyes (95%) and 32/32 eyes (100%), respectively, and 40/40 eyes (100%), and 31/32 eyes (97%), respectively, when correcting the OCT RNFLT measurement for the influence of variability in image signal/quality. The NST sensitivity was 8-10% higher than the single most sensitive traditional OCT RNFLT parameter; this difference was not statistically significant in this small sample. Conclusion: The NST showed high specificity and sensitivity for detection of RNFLT attenuation indicating early to severe glaucoma. Although promising, the NST needs to be further developed and validated in larger study samples and in patients with various stages of glaucomatous damage.},
  author       = {Hougaard, JL and Heijl, Anders and Krogh, E},
  issn         = {1395-3907},
  keyword      = {automated analysis,optical coherence tomography,diagnosis,retinal nerve fibre layer,glaucoma},
  language     = {eng},
  number       = {4},
  pages        = {410--418},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00},
  title        = {The nerve fibre layer symmetry test: computerized evaluation of human retinal nerve fibre layer thickness as measured by optical coherence tomography},
  url          = {http://dx.doi.org/10.1111/j.1395-3907.2004.00302.x},
  volume       = {82},
  year         = {2004},
}