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The nerve fibre layer symmetry test: computerized evaluation of human retinal nerve fibre layer thickness as measured by optical coherence tomography

Hougaard, Jesper Leth LU ; Heijl, Anders LU and Krogh, Erik (2004) In Acta Ophthalmologica Scandinavica 82(4). p.410-418
Abstract
Purpose: To present and test a new interpretative concept, the nerve fibre layer symmetry test (NST), for computerized evaluation of retinal nerve fibre layer thickness (RNFLT) as measured by optical coherence tomography (OCT) in glaucoma. Methods: The NST concept was constructed and tested in a pilot study. A total of 32 healthy and 40 age-matched glaucomatous eyes were included and examined by OCT, computerized perimetry, RNFL/disc photography, tonometry and a general ophthalmologic examination. Results: The observed NST sensitivity and specificity were high, at 38/40 eyes (95%) and 32/32 eyes (100%), respectively, and 40/40 eyes (100%), and 31/32 eyes (97%), respectively, when correcting the OCT RNFLT measurement for the influence of... (More)
Purpose: To present and test a new interpretative concept, the nerve fibre layer symmetry test (NST), for computerized evaluation of retinal nerve fibre layer thickness (RNFLT) as measured by optical coherence tomography (OCT) in glaucoma. Methods: The NST concept was constructed and tested in a pilot study. A total of 32 healthy and 40 age-matched glaucomatous eyes were included and examined by OCT, computerized perimetry, RNFL/disc photography, tonometry and a general ophthalmologic examination. Results: The observed NST sensitivity and specificity were high, at 38/40 eyes (95%) and 32/32 eyes (100%), respectively, and 40/40 eyes (100%), and 31/32 eyes (97%), respectively, when correcting the OCT RNFLT measurement for the influence of variability in image signal/quality. The NST sensitivity was 8-10% higher than the single most sensitive traditional OCT RNFLT parameter; this difference was not statistically significant in this small sample. Conclusion: The NST showed high specificity and sensitivity for detection of RNFLT attenuation indicating early to severe glaucoma. Although promising, the NST needs to be further developed and validated in larger study samples and in patients with various stages of glaucomatous damage. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
automated analysis, optical coherence tomography, diagnosis, retinal nerve fibre layer, glaucoma
in
Acta Ophthalmologica Scandinavica
volume
82
issue
4
pages
410 - 418
publisher
Wiley
external identifiers
  • pmid:15291934
  • wos:000223473100008
  • scopus:4444370753
  • pmid:15291934
ISSN
1395-3907
DOI
10.1111/j.1395-3907.2004.00302.x
language
English
LU publication?
yes
id
9aa91c96-07cf-46c8-b0b3-3751a992e185 (old id 898558)
date added to LUP
2016-04-01 15:50:01
date last changed
2022-01-28 07:27:44
@article{9aa91c96-07cf-46c8-b0b3-3751a992e185,
  abstract     = {{Purpose: To present and test a new interpretative concept, the nerve fibre layer symmetry test (NST), for computerized evaluation of retinal nerve fibre layer thickness (RNFLT) as measured by optical coherence tomography (OCT) in glaucoma. Methods: The NST concept was constructed and tested in a pilot study. A total of 32 healthy and 40 age-matched glaucomatous eyes were included and examined by OCT, computerized perimetry, RNFL/disc photography, tonometry and a general ophthalmologic examination. Results: The observed NST sensitivity and specificity were high, at 38/40 eyes (95%) and 32/32 eyes (100%), respectively, and 40/40 eyes (100%), and 31/32 eyes (97%), respectively, when correcting the OCT RNFLT measurement for the influence of variability in image signal/quality. The NST sensitivity was 8-10% higher than the single most sensitive traditional OCT RNFLT parameter; this difference was not statistically significant in this small sample. Conclusion: The NST showed high specificity and sensitivity for detection of RNFLT attenuation indicating early to severe glaucoma. Although promising, the NST needs to be further developed and validated in larger study samples and in patients with various stages of glaucomatous damage.}},
  author       = {{Hougaard, Jesper Leth and Heijl, Anders and Krogh, Erik}},
  issn         = {{1395-3907}},
  keywords     = {{automated analysis; optical coherence tomography; diagnosis; retinal nerve fibre layer; glaucoma}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{410--418}},
  publisher    = {{Wiley}},
  series       = {{Acta Ophthalmologica Scandinavica}},
  title        = {{The nerve fibre layer symmetry test: computerized evaluation of human retinal nerve fibre layer thickness as measured by optical coherence tomography}},
  url          = {{http://dx.doi.org/10.1111/j.1395-3907.2004.00302.x}},
  doi          = {{10.1111/j.1395-3907.2004.00302.x}},
  volume       = {{82}},
  year         = {{2004}},
}