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Immunomodulation of atherosclerosis with a vaccine

Shah, PK; Chyu, KY; Fredrikson, Gunilla and Nilsson, Jan LU (2005) In Nature Clinical Practice Cardiovascular Medicine 2(12). p.639-646
Abstract
Experimental observations have established that the innate and adaptive immune mechanisms both have roles in the modulation of atherosclerosis. The complex function that the immune system has in the pathophysiology of atherosclerosis is highlighted by the fact that both proatherogenic and atheroprotective effects of immune activation can be demonstrated. An immune response to the protein and lipid components of oxidized LDL cholesterol has been observed in experimental models, and immunization with these antigens has generally reduced atherosclerosis. The findings suggest the tantalizing possibility that an atheroprotective vaccine can be developed. Our laboratories have identified several antigenic epitopes in the human apolipoprotein B... (More)
Experimental observations have established that the innate and adaptive immune mechanisms both have roles in the modulation of atherosclerosis. The complex function that the immune system has in the pathophysiology of atherosclerosis is highlighted by the fact that both proatherogenic and atheroprotective effects of immune activation can be demonstrated. An immune response to the protein and lipid components of oxidized LDL cholesterol has been observed in experimental models, and immunization with these antigens has generally reduced atherosclerosis. The findings suggest the tantalizing possibility that an atheroprotective vaccine can be developed. Our laboratories have identified several antigenic epitopes in the human apolipoprotein B 100 component of LDL cholesterol. Active immunization with some of these epitopes has reduced atherosclerosis in hyperlipidemic mice. We believe, therefore, that a vaccine based on apolipoprotein B100-related peptide could have a role in reducing atherosclerosis. In this review, we discuss the possible immunologic mechanisms by Which vaccines against atherosclerosis might work and the ways in which such treatment might be most effectively administered. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atheroprotective, atherosclerosis, immune response, vaccination, proatherogenic
in
Nature Clinical Practice Cardiovascular Medicine
volume
2
issue
12
pages
639 - 646
publisher
Nature Publishing Group
external identifiers
  • pmid:16306920
  • wos:000233319800010
  • scopus:29544439478
ISSN
1743-4300
DOI
10.1038/ncpcardio0372
language
English
LU publication?
yes
id
45f5c0c7-fa79-47c7-a9c6-cee4cffa272e (old id 898694)
date added to LUP
2008-01-22 14:54:14
date last changed
2017-01-15 03:33:36
@article{45f5c0c7-fa79-47c7-a9c6-cee4cffa272e,
  abstract     = {Experimental observations have established that the innate and adaptive immune mechanisms both have roles in the modulation of atherosclerosis. The complex function that the immune system has in the pathophysiology of atherosclerosis is highlighted by the fact that both proatherogenic and atheroprotective effects of immune activation can be demonstrated. An immune response to the protein and lipid components of oxidized LDL cholesterol has been observed in experimental models, and immunization with these antigens has generally reduced atherosclerosis. The findings suggest the tantalizing possibility that an atheroprotective vaccine can be developed. Our laboratories have identified several antigenic epitopes in the human apolipoprotein B 100 component of LDL cholesterol. Active immunization with some of these epitopes has reduced atherosclerosis in hyperlipidemic mice. We believe, therefore, that a vaccine based on apolipoprotein B100-related peptide could have a role in reducing atherosclerosis. In this review, we discuss the possible immunologic mechanisms by Which vaccines against atherosclerosis might work and the ways in which such treatment might be most effectively administered.},
  author       = {Shah, PK and Chyu, KY and Fredrikson, Gunilla and Nilsson, Jan},
  issn         = {1743-4300},
  keyword      = {atheroprotective,atherosclerosis,immune response,vaccination,proatherogenic},
  language     = {eng},
  number       = {12},
  pages        = {639--646},
  publisher    = {Nature Publishing Group},
  series       = {Nature Clinical Practice Cardiovascular Medicine},
  title        = {Immunomodulation of atherosclerosis with a vaccine},
  url          = {http://dx.doi.org/10.1038/ncpcardio0372},
  volume       = {2},
  year         = {2005},
}