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Partial splenic embolization as pretreatment for antiviral therapy in hepatitis C virus infection

Pålsson, Birger LU and Verbaan, Hans LU (2005) In European Journal of Gastroenterology and Hepathology 17(11). p.1153-1155
Abstract
Antiviral therapy in hepatitis C virus (HCV) infection is limited by haematological side-effects, especially thrombocytopenia and leucopenia. The pancytopenia associated with liver cirrhosis has multifactorial causes, but hypersplenism seems to be a major contributor, especially regarding thrombocytopenia. The use of PSE as a 'Pretreatment' in order to make more patients with HCV-induced cirrhosis and pancytopenia suitable for antiviral therapy using ribavirin and pegylated interferon is a new, promising concept. The setting needs further investigation in prospective, longitudinal studies, in order to evaluate safety, define patient selection criteria, the timing between the PSE procedure and the antiviral therapy and to evaluate the... (More)
Antiviral therapy in hepatitis C virus (HCV) infection is limited by haematological side-effects, especially thrombocytopenia and leucopenia. The pancytopenia associated with liver cirrhosis has multifactorial causes, but hypersplenism seems to be a major contributor, especially regarding thrombocytopenia. The use of PSE as a 'Pretreatment' in order to make more patients with HCV-induced cirrhosis and pancytopenia suitable for antiviral therapy using ribavirin and pegylated interferon is a new, promising concept. The setting needs further investigation in prospective, longitudinal studies, in order to evaluate safety, define patient selection criteria, the timing between the PSE procedure and the antiviral therapy and to evaluate the long-term results. The setting needs further investigation in prospective, longitudinal studies, in order to evaluate safety, define patient selection criteria, the timing between the PSE procedure and the antiviral therapy and to evaluate the long-term results. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
spleen, ribavirin, embolization, partial splenic, interferon, hypersplenism, cirrhosis, hepatitis C
in
European Journal of Gastroenterology and Hepathology
volume
17
issue
11
pages
1153 - 1155
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000233367700001
  • pmid:16215425
  • scopus:27344438027
ISSN
1473-5687
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
id
bf5aeb67-5784-4ff5-9087-cfbbdd751c18 (old id 898723)
alternative location
http://www.eurojgh.com/pt/re/ejgh/pdfhandler.00042737-200511000-00001.pdf;jsessionid=HTfW27vrN9byg5pQlYsvwKd4tqmJ92l2DsSRXztvnsnJVG6hYcHr!-1036421505!181195629!8091!-1
date added to LUP
2016-04-01 11:59:25
date last changed
2020-01-15 02:31:48
@article{bf5aeb67-5784-4ff5-9087-cfbbdd751c18,
  abstract     = {Antiviral therapy in hepatitis C virus (HCV) infection is limited by haematological side-effects, especially thrombocytopenia and leucopenia. The pancytopenia associated with liver cirrhosis has multifactorial causes, but hypersplenism seems to be a major contributor, especially regarding thrombocytopenia. The use of PSE as a 'Pretreatment' in order to make more patients with HCV-induced cirrhosis and pancytopenia suitable for antiviral therapy using ribavirin and pegylated interferon is a new, promising concept. The setting needs further investigation in prospective, longitudinal studies, in order to evaluate safety, define patient selection criteria, the timing between the PSE procedure and the antiviral therapy and to evaluate the long-term results. The setting needs further investigation in prospective, longitudinal studies, in order to evaluate safety, define patient selection criteria, the timing between the PSE procedure and the antiviral therapy and to evaluate the long-term results.},
  author       = {Pålsson, Birger and Verbaan, Hans},
  issn         = {1473-5687},
  language     = {eng},
  number       = {11},
  pages        = {1153--1155},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Gastroenterology and Hepathology},
  title        = {Partial splenic embolization as pretreatment for antiviral therapy in hepatitis C virus infection},
  url          = {http://www.eurojgh.com/pt/re/ejgh/pdfhandler.00042737-200511000-00001.pdf;jsessionid=HTfW27vrN9byg5pQlYsvwKd4tqmJ92l2DsSRXztvnsnJVG6hYcHr!-1036421505!181195629!8091!-1},
  volume       = {17},
  year         = {2005},
}