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Oral prednisone suppresses allergic but not irritant patch test reactions in individuals hypersensitive to nickel

Anveden, I; Lindberg, M; Andersen, KE; Bruze, Magnus LU ; Isaksson, Marléne LU ; Liden, C; Sommerlund, M; Wahlberg, JE; Wilkinson, JD and Willis, CM (2004) In Contact Dermatitis 50(5). p.298-303
Abstract
A multicentre, randomized, double-blind, crossover study was designed to investigate the effects of prednisone on allergic and irritant patch test reactions. 24 subjects with known allergy to nickel were recruited and patch tested with a nickel sulfate dilution series in aqueous solution, 5% nickel sulfate in petrolatum and 2 dilution series of the irritants nonanoic acid and sodium lauryl sulfate. The subjects were tested x2, both during treatment with prednisone 20 mg oral daily and during placebo treatment. The total number of positive nickel patch test reactions decreased significantly in patients during prednisone treatment. The threshold concentration to elicit a patch test reaction increased and the overall degree of reactivity to... (More)
A multicentre, randomized, double-blind, crossover study was designed to investigate the effects of prednisone on allergic and irritant patch test reactions. 24 subjects with known allergy to nickel were recruited and patch tested with a nickel sulfate dilution series in aqueous solution, 5% nickel sulfate in petrolatum and 2 dilution series of the irritants nonanoic acid and sodium lauryl sulfate. The subjects were tested x2, both during treatment with prednisone 20 mg oral daily and during placebo treatment. The total number of positive nickel patch test reactions decreased significantly in patients during prednisone treatment. The threshold concentration to elicit a patch test reaction increased and the overall degree of reactivity to nickel sulfate shifted towards weaker reactions. The effect of prednisone treatment on the response to irritants was divergent with both increased and decreased numbers of reactions, although there were no statistically significant differences compared with placebo. It is concluded that oral treatment with prednisone suppresses patch test reactivity to nickel, but not to the irritants tested. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sodium lauryl sulfate, prednisone, placebo, patch test reactivity, nonanoic acid, nickel, corticosteroids, suppression, allergic contact dermatitis
in
Contact Dermatitis
volume
50
issue
5
pages
298 - 303
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:15209811
  • wos:000222204600004
  • scopus:3042849251
ISSN
0105-1873
DOI
10.1111/j.0105-1873.2004.00340.x
language
English
LU publication?
yes
id
e6d69979-6f60-4df4-9147-e75c31700133 (old id 898890)
date added to LUP
2008-01-10 11:02:33
date last changed
2017-12-10 03:46:05
@article{e6d69979-6f60-4df4-9147-e75c31700133,
  abstract     = {A multicentre, randomized, double-blind, crossover study was designed to investigate the effects of prednisone on allergic and irritant patch test reactions. 24 subjects with known allergy to nickel were recruited and patch tested with a nickel sulfate dilution series in aqueous solution, 5% nickel sulfate in petrolatum and 2 dilution series of the irritants nonanoic acid and sodium lauryl sulfate. The subjects were tested x2, both during treatment with prednisone 20 mg oral daily and during placebo treatment. The total number of positive nickel patch test reactions decreased significantly in patients during prednisone treatment. The threshold concentration to elicit a patch test reaction increased and the overall degree of reactivity to nickel sulfate shifted towards weaker reactions. The effect of prednisone treatment on the response to irritants was divergent with both increased and decreased numbers of reactions, although there were no statistically significant differences compared with placebo. It is concluded that oral treatment with prednisone suppresses patch test reactivity to nickel, but not to the irritants tested.},
  author       = {Anveden, I and Lindberg, M and Andersen, KE and Bruze, Magnus and Isaksson, Marléne and Liden, C and Sommerlund, M and Wahlberg, JE and Wilkinson, JD and Willis, CM},
  issn         = {0105-1873},
  keyword      = {sodium lauryl sulfate,prednisone,placebo,patch test reactivity,nonanoic acid,nickel,corticosteroids,suppression,allergic contact dermatitis},
  language     = {eng},
  number       = {5},
  pages        = {298--303},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Oral prednisone suppresses allergic but not irritant patch test reactions in individuals hypersensitive to nickel},
  url          = {http://dx.doi.org/10.1111/j.0105-1873.2004.00340.x},
  volume       = {50},
  year         = {2004},
}