Generating highly polarized nuclear spins in solution using dynamic nuclear polarization
(2004) In Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment 526(1-2). p.173-181- Abstract
- A method to generate strongly polarized nuclear spins in solution has been developed, using Dynamic Nuclear Polarization (DNP) at a temperature of 1.2 K, and at a field of 3.354 T, corresponding to an electron spin resonance frequency of 94 GHz. Trityl radicals are used to directly polarize C-13 and other low-gamma nuclei. Subsequent to the DNP process, the solid sample is dissolved rapidly with a warm solvent to create a solution of molecules with highly polarized nuclear spins. Two main applications are proposed: high-resolution liquid state NMR with enhanced sensitivity, and the use of the hyper-polarized solution as an MR imaging agent. (C) 2003 Elsevier B.V. All rights reserved.
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https://lup.lub.lu.se/record/898910
- author
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- dynamic nuclear polarization, NMR spectroscopy, magnetic resonance, imaging, hyper polarization
- in
- Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment
- volume
- 526
- issue
- 1-2
- pages
- 173 - 181
- publisher
- Elsevier
- external identifiers
-
- wos:000222131500030
- scopus:2942557029
- ISSN
- 0167-5087
- DOI
- 10.1016/j.nima.2004.03.171
- language
- English
- LU publication?
- yes
- id
- b6bac54c-9818-4172-9ddc-57a2ac1ea9f2 (old id 898910)
- date added to LUP
- 2016-04-01 17:07:01
- date last changed
- 2022-04-15 17:16:32
@article{b6bac54c-9818-4172-9ddc-57a2ac1ea9f2, abstract = {{A method to generate strongly polarized nuclear spins in solution has been developed, using Dynamic Nuclear Polarization (DNP) at a temperature of 1.2 K, and at a field of 3.354 T, corresponding to an electron spin resonance frequency of 94 GHz. Trityl radicals are used to directly polarize C-13 and other low-gamma nuclei. Subsequent to the DNP process, the solid sample is dissolved rapidly with a warm solvent to create a solution of molecules with highly polarized nuclear spins. Two main applications are proposed: high-resolution liquid state NMR with enhanced sensitivity, and the use of the hyper-polarized solution as an MR imaging agent. (C) 2003 Elsevier B.V. All rights reserved.}}, author = {{Wolber, J and Ellner, F and Fridlund, B and Gram, A and Johannesson, H and Hansson, G and Hansson, LH and Lerche, MH and Månsson, Sven and Servin, R and Thaning, M and Golman, K and Ardenkjaer-Larsen, JH}}, issn = {{0167-5087}}, keywords = {{dynamic nuclear polarization; NMR spectroscopy; magnetic resonance; imaging; hyper polarization}}, language = {{eng}}, number = {{1-2}}, pages = {{173--181}}, publisher = {{Elsevier}}, series = {{Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment}}, title = {{Generating highly polarized nuclear spins in solution using dynamic nuclear polarization}}, url = {{http://dx.doi.org/10.1016/j.nima.2004.03.171}}, doi = {{10.1016/j.nima.2004.03.171}}, volume = {{526}}, year = {{2004}}, }