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Generating highly polarized nuclear spins in solution using dynamic nuclear polarization

Wolber, J; Ellner, F; Fridlund, B; Gram, A; Johannesson, H; Hansson, G; Hansson, LH; Lerche, MH; Månsson, Sven LU and Servin, R, et al. (2004) In Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment 526(1-2). p.173-181
Abstract
A method to generate strongly polarized nuclear spins in solution has been developed, using Dynamic Nuclear Polarization (DNP) at a temperature of 1.2 K, and at a field of 3.354 T, corresponding to an electron spin resonance frequency of 94 GHz. Trityl radicals are used to directly polarize C-13 and other low-gamma nuclei. Subsequent to the DNP process, the solid sample is dissolved rapidly with a warm solvent to create a solution of molecules with highly polarized nuclear spins. Two main applications are proposed: high-resolution liquid state NMR with enhanced sensitivity, and the use of the hyper-polarized solution as an MR imaging agent. (C) 2003 Elsevier B.V. All rights reserved.
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publication status
published
subject
keywords
dynamic nuclear polarization, NMR spectroscopy, magnetic resonance, imaging, hyper polarization
in
Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment
volume
526
issue
1-2
pages
173 - 181
publisher
Elsevier
external identifiers
  • wos:000222131500030
  • scopus:2942557029
ISSN
0167-5087
DOI
10.1016/j.nima.2004.03.171
language
English
LU publication?
yes
id
b6bac54c-9818-4172-9ddc-57a2ac1ea9f2 (old id 898910)
date added to LUP
2008-01-18 14:59:43
date last changed
2017-10-08 04:25:51
@article{b6bac54c-9818-4172-9ddc-57a2ac1ea9f2,
  abstract     = {A method to generate strongly polarized nuclear spins in solution has been developed, using Dynamic Nuclear Polarization (DNP) at a temperature of 1.2 K, and at a field of 3.354 T, corresponding to an electron spin resonance frequency of 94 GHz. Trityl radicals are used to directly polarize C-13 and other low-gamma nuclei. Subsequent to the DNP process, the solid sample is dissolved rapidly with a warm solvent to create a solution of molecules with highly polarized nuclear spins. Two main applications are proposed: high-resolution liquid state NMR with enhanced sensitivity, and the use of the hyper-polarized solution as an MR imaging agent. (C) 2003 Elsevier B.V. All rights reserved.},
  author       = {Wolber, J and Ellner, F and Fridlund, B and Gram, A and Johannesson, H and Hansson, G and Hansson, LH and Lerche, MH and Månsson, Sven and Servin, R and Thaning, M and Golman, K and Ardenkjaer-Larsen, JH},
  issn         = {0167-5087},
  keyword      = {dynamic nuclear polarization,NMR spectroscopy,magnetic resonance,imaging,hyper polarization},
  language     = {eng},
  number       = {1-2},
  pages        = {173--181},
  publisher    = {Elsevier},
  series       = {Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment},
  title        = {Generating highly polarized nuclear spins in solution using dynamic nuclear polarization},
  url          = {http://dx.doi.org/10.1016/j.nima.2004.03.171},
  volume       = {526},
  year         = {2004},
}