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CRP and IL-6 concentrations are associated with poor glycemic control despite preserved beta-cell function during the first year after diagnosis of type 1 diabetes

Scholin, A; Siegbahn, A; Lind, L; Berne, C; Sundkvist, Göran LU ; Bjork, E and Karlsson, FA (2004) In Diabetes/Metabolism Research Reviews 20(3). p.205-210
Abstract
Background The role of non-specific inflammation in beta-cell loss in type 1 diabetes is unclear. in the present study, inflammatory markers were determined in patients with newly diagnosed disease and related to beta-cell function, glycemic control and autoimmunity. Methods Ninety-seven adult patients with type 1 diabetes mellitus (80% islet antibody positives, ab(+)) were examined at diagnosis and 3, 6, 9 and 12 months after the start of insulin treatment. Plasma C-reactive protein (CRP), interleukin-6 (IL-6), C-peptide, islet autoantibodies, insulin requirement and HbA(1c) were assessed. Results The concentrations of CRP were high-normal at diagnosis and did not change during the study period. A positive correlation between CRP at... (More)
Background The role of non-specific inflammation in beta-cell loss in type 1 diabetes is unclear. in the present study, inflammatory markers were determined in patients with newly diagnosed disease and related to beta-cell function, glycemic control and autoimmunity. Methods Ninety-seven adult patients with type 1 diabetes mellitus (80% islet antibody positives, ab(+)) were examined at diagnosis and 3, 6, 9 and 12 months after the start of insulin treatment. Plasma C-reactive protein (CRP), interleukin-6 (IL-6), C-peptide, islet autoantibodies, insulin requirement and HbA(1c) were assessed. Results The concentrations of CRP were high-normal at diagnosis and did not change during the study period. A positive correlation between CRP at diagnosis and BMI was observed in ab(+) as well as in ab(+) cases. Detectable concentrations of IL-6 were found in 32% (157/485) of the samples and did not change during the study. Ab(-) patients had higher values of CRP at diagnosis and throughout the study compared to the ab(+). Among the ab(+) patients, CRP concentrations during the study were positively correlated to C-peptide at 12 months and an increase in HbA(1c), levels between 6 and 12 months. No associations between the presence or levels of islet autoantibodies and CRP were noted. Conclusions In type 1 diabetes, the islet destructive process and the development of beta-cell remission are not associated with changes in CRP or IL-6. instead, elevated CRP concentrations are prevalent and seem to reflect insulin resistance, as positive associations to BMI, C-peptide and deterioration of glycemic control were observed. Copyright (C) 2004 John Wiley Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
plasma C-peptide, autoantibodies, islet, interleukin-6, C-reactive protein, type 1 diabetes, inflammation
in
Diabetes/Metabolism Research Reviews
volume
20
issue
3
pages
205 - 210
publisher
John Wiley & Sons
external identifiers
  • wos:000221566300005
  • scopus:2642552200
ISSN
1520-7552
DOI
10.1002/dmrr.427
language
English
LU publication?
yes
id
15dac135-bec8-471d-9ff5-435dbe75d802 (old id 898983)
date added to LUP
2008-01-18 12:18:54
date last changed
2017-05-21 03:45:45
@article{15dac135-bec8-471d-9ff5-435dbe75d802,
  abstract     = {Background The role of non-specific inflammation in beta-cell loss in type 1 diabetes is unclear. in the present study, inflammatory markers were determined in patients with newly diagnosed disease and related to beta-cell function, glycemic control and autoimmunity. Methods Ninety-seven adult patients with type 1 diabetes mellitus (80% islet antibody positives, ab(+)) were examined at diagnosis and 3, 6, 9 and 12 months after the start of insulin treatment. Plasma C-reactive protein (CRP), interleukin-6 (IL-6), C-peptide, islet autoantibodies, insulin requirement and HbA(1c) were assessed. Results The concentrations of CRP were high-normal at diagnosis and did not change during the study period. A positive correlation between CRP at diagnosis and BMI was observed in ab(+) as well as in ab(+) cases. Detectable concentrations of IL-6 were found in 32% (157/485) of the samples and did not change during the study. Ab(-) patients had higher values of CRP at diagnosis and throughout the study compared to the ab(+). Among the ab(+) patients, CRP concentrations during the study were positively correlated to C-peptide at 12 months and an increase in HbA(1c), levels between 6 and 12 months. No associations between the presence or levels of islet autoantibodies and CRP were noted. Conclusions In type 1 diabetes, the islet destructive process and the development of beta-cell remission are not associated with changes in CRP or IL-6. instead, elevated CRP concentrations are prevalent and seem to reflect insulin resistance, as positive associations to BMI, C-peptide and deterioration of glycemic control were observed. Copyright (C) 2004 John Wiley Sons, Ltd.},
  author       = {Scholin, A and Siegbahn, A and Lind, L and Berne, C and Sundkvist, Göran and Bjork, E and Karlsson, FA},
  issn         = {1520-7552},
  keyword      = {plasma C-peptide,autoantibodies,islet,interleukin-6,C-reactive protein,type 1 diabetes,inflammation},
  language     = {eng},
  number       = {3},
  pages        = {205--210},
  publisher    = {John Wiley & Sons},
  series       = {Diabetes/Metabolism Research Reviews},
  title        = {CRP and IL-6 concentrations are associated with poor glycemic control despite preserved beta-cell function during the first year after diagnosis of type 1 diabetes},
  url          = {http://dx.doi.org/10.1002/dmrr.427},
  volume       = {20},
  year         = {2004},
}