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Upper extremity deep venous thrombosis in patients with 5-fluorouracil-containing adjuvant chemotherapy - Three case reports and a review

Tham, J and Albertsson, Maria LU (2004) In Acta Oncologica 43(1). p.108-112
Abstract
Catheter-related deep venous thrombosis is a complication that can occur in patients receiving chemotherapy. Three such cases are described and a review of the literature is made, focusing on recent results regarding possible thrombogenic mechanisms and the high prevalence of non-symptomatic thrombosis as well as the high morbidity and mortality associated with upper extremity deep venous thrombosis. Special emphasis is given to the cytotoxic effects of 5-fluorouracil on vascular endothelium and the likely link to thrombotic complications. The possible differences between two different methods of administering chemotherapy, continuous infusion and bolus dose administration, in this regard are briefly discussed. It is concluded that the... (More)
Catheter-related deep venous thrombosis is a complication that can occur in patients receiving chemotherapy. Three such cases are described and a review of the literature is made, focusing on recent results regarding possible thrombogenic mechanisms and the high prevalence of non-symptomatic thrombosis as well as the high morbidity and mortality associated with upper extremity deep venous thrombosis. Special emphasis is given to the cytotoxic effects of 5-fluorouracil on vascular endothelium and the likely link to thrombotic complications. The possible differences between two different methods of administering chemotherapy, continuous infusion and bolus dose administration, in this regard are briefly discussed. It is concluded that the first steps towards an understanding of the mechanisms behind the vascular effects of 5-fluorouracil have been taken. Much remains to be done before active interaction with the pathogenic processes leading to vascular and cardiac complications can be realized, yet various forms of anticoagulant therapy could well be an efficient form of prophylaxis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
43
issue
1
pages
108 - 112
publisher
Taylor & Francis
external identifiers
  • wos:000188764600018
  • pmid:15068328
  • scopus:1442265880
ISSN
1651-226X
DOI
10.1080/02841860310021545
language
English
LU publication?
yes
id
76369c7a-1bba-48ee-bd3e-4d4267f6130e (old id 899383)
date added to LUP
2008-01-18 13:57:18
date last changed
2017-12-03 03:38:05
@article{76369c7a-1bba-48ee-bd3e-4d4267f6130e,
  abstract     = {Catheter-related deep venous thrombosis is a complication that can occur in patients receiving chemotherapy. Three such cases are described and a review of the literature is made, focusing on recent results regarding possible thrombogenic mechanisms and the high prevalence of non-symptomatic thrombosis as well as the high morbidity and mortality associated with upper extremity deep venous thrombosis. Special emphasis is given to the cytotoxic effects of 5-fluorouracil on vascular endothelium and the likely link to thrombotic complications. The possible differences between two different methods of administering chemotherapy, continuous infusion and bolus dose administration, in this regard are briefly discussed. It is concluded that the first steps towards an understanding of the mechanisms behind the vascular effects of 5-fluorouracil have been taken. Much remains to be done before active interaction with the pathogenic processes leading to vascular and cardiac complications can be realized, yet various forms of anticoagulant therapy could well be an efficient form of prophylaxis.},
  author       = {Tham, J and Albertsson, Maria},
  issn         = {1651-226X},
  language     = {eng},
  number       = {1},
  pages        = {108--112},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Upper extremity deep venous thrombosis in patients with 5-fluorouracil-containing adjuvant chemotherapy - Three case reports and a review},
  url          = {http://dx.doi.org/10.1080/02841860310021545},
  volume       = {43},
  year         = {2004},
}