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Endothelial expression of MHC class II molecules in autoimmune disease

Turesson, Carl LU (2004) In Current Pharmaceutical Design 10(2). p.129-143
Abstract
Major histocompatibility complex (MHC) class II molecules are up-regulated on endothelial cells in human allografts, and are thought to be involved in graft rejection. The MFIC class 11 subtypes HLA-DR, DQ and DP regulate T cell dependent immune responses, and aberrant expression could be important in autoimmunity. Increased endothelial MHC class II expression has been demonstrated in several autoimmune diseases, including myocarditis with dilated cardiomyopathy, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Recent data suggest that there is an association between endothelial expression of MHC class II molecules and diffuse endothelial dysfunction, which may be part of the explanation of the increased risk of... (More)
Major histocompatibility complex (MHC) class II molecules are up-regulated on endothelial cells in human allografts, and are thought to be involved in graft rejection. The MFIC class 11 subtypes HLA-DR, DQ and DP regulate T cell dependent immune responses, and aberrant expression could be important in autoimmunity. Increased endothelial MHC class II expression has been demonstrated in several autoimmune diseases, including myocarditis with dilated cardiomyopathy, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Recent data suggest that there is an association between endothelial expression of MHC class II molecules and diffuse endothelial dysfunction, which may be part of the explanation of the increased risk of cardiovascular disease in patients with RA, SLE and other chronic inflammatory conditions. MHC class II transcription is in part genetically determined. Cytokine induced up-regulation of MHC class II molecules can be inhibited in vitro by antioxidants and different drugs, such as cyclosporin and statins. Research on the development of new treatments for systemic autoimmune diseases and cardiovascular disease should include evaluation of effects on endothelial activation, including MHC class II expression. This review also discusses the genetic basis of MHC class II expression and its implications for understanding MHC genotype associations with autoimmune diseases. Recent studies of interactions between endothelial cells and T cells are reviewed. Such interactions could be of major importance in the pathogenesis of autoimmune and vascular diseases. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
major histocompatibility complex class II, endothelial cells, endothelial activation, HLA-DR, T cells, HLA-DQ, cardiovascular disease, rheumatoid arthritis
in
Current Pharmaceutical Design
volume
10
issue
2
pages
129 - 143
publisher
Bentham Science Publishers
external identifiers
  • pmid:14754393
  • wos:000187996700004
  • scopus:0347286787
ISSN
1381-6128
DOI
10.2174/1381612043453414
language
English
LU publication?
yes
id
2e8c6ffe-c367-4080-8bed-de5e711b6190 (old id 899561)
date added to LUP
2008-01-18 14:33:27
date last changed
2017-12-10 03:41:43
@article{2e8c6ffe-c367-4080-8bed-de5e711b6190,
  abstract     = {Major histocompatibility complex (MHC) class II molecules are up-regulated on endothelial cells in human allografts, and are thought to be involved in graft rejection. The MFIC class 11 subtypes HLA-DR, DQ and DP regulate T cell dependent immune responses, and aberrant expression could be important in autoimmunity. Increased endothelial MHC class II expression has been demonstrated in several autoimmune diseases, including myocarditis with dilated cardiomyopathy, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Recent data suggest that there is an association between endothelial expression of MHC class II molecules and diffuse endothelial dysfunction, which may be part of the explanation of the increased risk of cardiovascular disease in patients with RA, SLE and other chronic inflammatory conditions. MHC class II transcription is in part genetically determined. Cytokine induced up-regulation of MHC class II molecules can be inhibited in vitro by antioxidants and different drugs, such as cyclosporin and statins. Research on the development of new treatments for systemic autoimmune diseases and cardiovascular disease should include evaluation of effects on endothelial activation, including MHC class II expression. This review also discusses the genetic basis of MHC class II expression and its implications for understanding MHC genotype associations with autoimmune diseases. Recent studies of interactions between endothelial cells and T cells are reviewed. Such interactions could be of major importance in the pathogenesis of autoimmune and vascular diseases.},
  author       = {Turesson, Carl},
  issn         = {1381-6128},
  keyword      = {major histocompatibility complex class II,endothelial cells,endothelial activation,HLA-DR,T cells,HLA-DQ,cardiovascular disease,rheumatoid arthritis},
  language     = {eng},
  number       = {2},
  pages        = {129--143},
  publisher    = {Bentham Science Publishers},
  series       = {Current Pharmaceutical Design},
  title        = {Endothelial expression of MHC class II molecules in autoimmune disease},
  url          = {http://dx.doi.org/10.2174/1381612043453414},
  volume       = {10},
  year         = {2004},
}