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Follow-up after colorectal cancer surgery

Ohlsson, B and Pålsson, Birger LU (2003) In Acta Oncologica 42(8). p.816-826
Abstract
Although most institutions offer some kind of follow-up to patients operated on for colorectal cancer, its value with respect to prolonged survival has been challenged. However, improved results of liver surgery and chemotherapy make it reasonable to assume that a follow-up programme leading to detection of more asymptomatic recurrences would result in improved survival. Liver metastases and extramural local recurrences are the most common secondary lesions and 5-year survival rates of about 30% are reported after radical resection. From these observations a survival benefit could be expected when follow-up is directed to these forms of recurrence. From six randomized studies, six comparative cohort studies and four meta-analyses it can be... (More)
Although most institutions offer some kind of follow-up to patients operated on for colorectal cancer, its value with respect to prolonged survival has been challenged. However, improved results of liver surgery and chemotherapy make it reasonable to assume that a follow-up programme leading to detection of more asymptomatic recurrences would result in improved survival. Liver metastases and extramural local recurrences are the most common secondary lesions and 5-year survival rates of about 30% are reported after radical resection. From these observations a survival benefit could be expected when follow-up is directed to these forms of recurrence. From six randomized studies, six comparative cohort studies and four meta-analyses it can be concluded that an intensive follow-up programme results in more recurrences being resected for cure and about a 10% higher 5-year survival rate compared with less intensive or no follow-up. However, the differences in the follow-up protocols make it difficult to conclude how a follow-up programme should be designed. Liver imaging and carcinoembryonic antigen assay should probably be included, while the yield of frequent colonoscopies is small. A follow-up regimen based on these principles is suggested. Future studies should focus on which tests are the most cost-effective for follow- up after colorectal cancer resection. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
42
issue
8
pages
816 - 826
publisher
Taylor & Francis
external identifiers
  • wos:000187149200004
  • pmid:14968942
  • scopus:0347756678
ISSN
1651-226X
DOI
10.1080/02841860310019016
language
English
LU publication?
yes
id
b3cafb83-65b0-4897-8dca-8f0d9cc3bfb9 (old id 899654)
date added to LUP
2008-01-15 09:52:10
date last changed
2018-01-07 09:33:11
@article{b3cafb83-65b0-4897-8dca-8f0d9cc3bfb9,
  abstract     = {Although most institutions offer some kind of follow-up to patients operated on for colorectal cancer, its value with respect to prolonged survival has been challenged. However, improved results of liver surgery and chemotherapy make it reasonable to assume that a follow-up programme leading to detection of more asymptomatic recurrences would result in improved survival. Liver metastases and extramural local recurrences are the most common secondary lesions and 5-year survival rates of about 30% are reported after radical resection. From these observations a survival benefit could be expected when follow-up is directed to these forms of recurrence. From six randomized studies, six comparative cohort studies and four meta-analyses it can be concluded that an intensive follow-up programme results in more recurrences being resected for cure and about a 10% higher 5-year survival rate compared with less intensive or no follow-up. However, the differences in the follow-up protocols make it difficult to conclude how a follow-up programme should be designed. Liver imaging and carcinoembryonic antigen assay should probably be included, while the yield of frequent colonoscopies is small. A follow-up regimen based on these principles is suggested. Future studies should focus on which tests are the most cost-effective for follow- up after colorectal cancer resection.},
  author       = {Ohlsson, B and Pålsson, Birger},
  issn         = {1651-226X},
  language     = {eng},
  number       = {8},
  pages        = {816--826},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Follow-up after colorectal cancer surgery},
  url          = {http://dx.doi.org/10.1080/02841860310019016},
  volume       = {42},
  year         = {2003},
}