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Allergic contact dermatitis from dicyclohexylmethane-4,4 '-diisocyanate

Engfeldt, Malin LU ; Björkner, Bert LU ; Hamnerius, N and Zimerson, Erik LU (2003) In Contact Dermatitis 48(6). p.305-309
Abstract
From August 1999 to April 2001, there was an outbreak of severe eczema at a factory manufacturing medical equipment. A glue, mainly based on the isocyanate dicyclohexylmethane-4,4'-diisocyanate (DMDI), was suspected as being the cause of the problem. 16 workers with recent episodes of eczema were patch tested with a standard series, an isocyanate series and work material. The latter consisted of, among other things, the glue, DMDI, and an amine, dicyclohexylmethane-4,4'-diamine (DMDA), which is formed when DMDI reacts with water. 13 patients reacted to DMDI, 9 to 1,6-hamethylenediisocyanate (HDI) and 4 to isophoronediisocyanate (IPDI), all of which are aliphatic isocyanates. None reacted to the aromatic isocyanates,... (More)
From August 1999 to April 2001, there was an outbreak of severe eczema at a factory manufacturing medical equipment. A glue, mainly based on the isocyanate dicyclohexylmethane-4,4'-diisocyanate (DMDI), was suspected as being the cause of the problem. 16 workers with recent episodes of eczema were patch tested with a standard series, an isocyanate series and work material. The latter consisted of, among other things, the glue, DMDI, and an amine, dicyclohexylmethane-4,4'-diamine (DMDA), which is formed when DMDI reacts with water. 13 patients reacted to DMDI, 9 to 1,6-hamethylenediisocyanate (HDI) and 4 to isophoronediisocyanate (IPDI), all of which are aliphatic isocyanates. None reacted to the aromatic isocyanates, diphenylmethane-4,4'-diisocyanate (MDI) or toluenediisocyanate (TDI). One explanation for this pattern could be that aromatic diisocyanates are more reactive than the aliphatic ones and that, therefore, they are inactivated before penetrating the skin. 5 patients reacted to DMDA and 5 to 4,4-diaminodiphenylmethane (MDA). Concurrent reactions to DMDA and or MDA with DMDI could be due to cross-reactivity. The positive reactions to MDA could also be a marker of MDI exposure. Yet another patient, investigated in 1997 with suspected work-related contact dermatitis from the glue, is described. She, however, showed no positive reactions to any isocyanates. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
polyurethane, occupational, methylenebis(4-cyclohexylisocyanate), DMDI, contact allergy, CAS 5124-30-1, CAS 1761-71-3, 4 ' diisocyanate, dicyclohexylmethane-4, allergic contact dermatitis
in
Contact Dermatitis
volume
48
issue
6
pages
305 - 309
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:14531868
  • wos:000186231100003
  • scopus:0042886802
ISSN
0105-1873
DOI
10.1034/j.1600-0536.2003.00123.x
language
English
LU publication?
yes
id
1f867459-0fa0-4e4e-8b6b-18f847d618dd (old id 899814)
date added to LUP
2008-01-11 13:37:07
date last changed
2018-01-07 05:53:27
@article{1f867459-0fa0-4e4e-8b6b-18f847d618dd,
  abstract     = {From August 1999 to April 2001, there was an outbreak of severe eczema at a factory manufacturing medical equipment. A glue, mainly based on the isocyanate dicyclohexylmethane-4,4'-diisocyanate (DMDI), was suspected as being the cause of the problem. 16 workers with recent episodes of eczema were patch tested with a standard series, an isocyanate series and work material. The latter consisted of, among other things, the glue, DMDI, and an amine, dicyclohexylmethane-4,4'-diamine (DMDA), which is formed when DMDI reacts with water. 13 patients reacted to DMDI, 9 to 1,6-hamethylenediisocyanate (HDI) and 4 to isophoronediisocyanate (IPDI), all of which are aliphatic isocyanates. None reacted to the aromatic isocyanates, diphenylmethane-4,4'-diisocyanate (MDI) or toluenediisocyanate (TDI). One explanation for this pattern could be that aromatic diisocyanates are more reactive than the aliphatic ones and that, therefore, they are inactivated before penetrating the skin. 5 patients reacted to DMDA and 5 to 4,4-diaminodiphenylmethane (MDA). Concurrent reactions to DMDA and or MDA with DMDI could be due to cross-reactivity. The positive reactions to MDA could also be a marker of MDI exposure. Yet another patient, investigated in 1997 with suspected work-related contact dermatitis from the glue, is described. She, however, showed no positive reactions to any isocyanates.},
  author       = {Engfeldt, Malin and Björkner, Bert and Hamnerius, N and Zimerson, Erik},
  issn         = {0105-1873},
  keyword      = {polyurethane,occupational,methylenebis(4-cyclohexylisocyanate),DMDI,contact allergy,CAS 5124-30-1,CAS 1761-71-3,4 ' diisocyanate,dicyclohexylmethane-4,allergic contact dermatitis},
  language     = {eng},
  number       = {6},
  pages        = {305--309},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Allergic contact dermatitis from dicyclohexylmethane-4,4 '-diisocyanate},
  url          = {http://dx.doi.org/10.1034/j.1600-0536.2003.00123.x},
  volume       = {48},
  year         = {2003},
}