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Hydroxyisohexyl 3-cyclohexene carboxaldehyde-known as Lyral (R): quantitative aspects and risk assessment of an important fragrance allergen

Johansen, JD; Frosch, PJ; Svedman, Cecilia LU ; Andersen, KE; Bruze, Magnus LU ; Pirker, C and Menne, T (2003) In Contact Dermatitis 48(6). p.310-316
Abstract
Hydroxyisohexyl 3-cyclohexene carboxaldehyde, also known as Lyral(R), is a fragrance ingredient identified as the cause of contact allergic reactions in 2-3% of eczema patients undergoing patch testing. Lyral(R) has been included in the standard patch test series in many clinics due to its importance as an allergen. It has been used without restrictions in cosmetic products, until now. In the present study, the dose-response relationship of Lyral(R) contact allergy was studied with doses relevant for normal exposure in cosmetic products. 18 eczema patients, who previously had given a positive patch test to Lyral(R) 5% petrolatum, were included along with 7 control subjects. All cases were tested with a serial dilution of Lyral(R) in... (More)
Hydroxyisohexyl 3-cyclohexene carboxaldehyde, also known as Lyral(R), is a fragrance ingredient identified as the cause of contact allergic reactions in 2-3% of eczema patients undergoing patch testing. Lyral(R) has been included in the standard patch test series in many clinics due to its importance as an allergen. It has been used without restrictions in cosmetic products, until now. In the present study, the dose-response relationship of Lyral(R) contact allergy was studied with doses relevant for normal exposure in cosmetic products. 18 eczema patients, who previously had given a positive patch test to Lyral(R) 5% petrolatum, were included along with 7 control subjects. All cases were tested with a serial dilution of Lyral(R) in ethanol 6% to 6 p.p.m and subjected to a 2-week, repeated open application test with a low dose of Lyral(R) in ethanol. In the case of no reaction, this was followed by another 2 weeks of testing with a higher dose. The test was performed at the volar aspect of the forearm. In 16 of 18 cases (89%), a positive use test developed, 11 reacting to the low and 5 to the high concentration. None reacted to the vehicle control of ethanol applied to the contralateral arm. All controls were negative to both the test solutions of Lyral(R) and the ethanol control. The difference between the test and the control group was statistically significant (Fisher's test, P < 0.001). It is concluded that Lyral(R) at the current usage levels is inducing sensitization in the community. The same levels were shown to elicit allergic contact dermatitis in almost all sensitized individuals. A significant reduction in usage concentrations is recommended to prevent contact allergic reactions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sensitization, risk assessment, prevention, Lyral (R), carboxaldehyde, hydroxyisohexyl-3-cyclohexene, fragrance, cosmetics, elicitation
in
Contact Dermatitis
volume
48
issue
6
pages
310 - 316
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000186231100004
  • pmid:14531869
  • scopus:0142226852
ISSN
0105-1873
DOI
10.1034/j.1600-0536.2003.00126.x
language
English
LU publication?
yes
id
3c116714-116b-4f2f-86e4-194c9e442348 (old id 899819)
date added to LUP
2008-01-14 14:51:21
date last changed
2018-01-07 05:31:29
@article{3c116714-116b-4f2f-86e4-194c9e442348,
  abstract     = {Hydroxyisohexyl 3-cyclohexene carboxaldehyde, also known as Lyral(R), is a fragrance ingredient identified as the cause of contact allergic reactions in 2-3% of eczema patients undergoing patch testing. Lyral(R) has been included in the standard patch test series in many clinics due to its importance as an allergen. It has been used without restrictions in cosmetic products, until now. In the present study, the dose-response relationship of Lyral(R) contact allergy was studied with doses relevant for normal exposure in cosmetic products. 18 eczema patients, who previously had given a positive patch test to Lyral(R) 5% petrolatum, were included along with 7 control subjects. All cases were tested with a serial dilution of Lyral(R) in ethanol 6% to 6 p.p.m and subjected to a 2-week, repeated open application test with a low dose of Lyral(R) in ethanol. In the case of no reaction, this was followed by another 2 weeks of testing with a higher dose. The test was performed at the volar aspect of the forearm. In 16 of 18 cases (89%), a positive use test developed, 11 reacting to the low and 5 to the high concentration. None reacted to the vehicle control of ethanol applied to the contralateral arm. All controls were negative to both the test solutions of Lyral(R) and the ethanol control. The difference between the test and the control group was statistically significant (Fisher's test, P &lt; 0.001). It is concluded that Lyral(R) at the current usage levels is inducing sensitization in the community. The same levels were shown to elicit allergic contact dermatitis in almost all sensitized individuals. A significant reduction in usage concentrations is recommended to prevent contact allergic reactions.},
  author       = {Johansen, JD and Frosch, PJ and Svedman, Cecilia and Andersen, KE and Bruze, Magnus and Pirker, C and Menne, T},
  issn         = {0105-1873},
  keyword      = {sensitization,risk assessment,prevention,Lyral (R),carboxaldehyde,hydroxyisohexyl-3-cyclohexene,fragrance,cosmetics,elicitation},
  language     = {eng},
  number       = {6},
  pages        = {310--316},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Hydroxyisohexyl 3-cyclohexene carboxaldehyde-known as Lyral (R): quantitative aspects and risk assessment of an important fragrance allergen},
  url          = {http://dx.doi.org/10.1034/j.1600-0536.2003.00126.x},
  volume       = {48},
  year         = {2003},
}