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Human Leucocyte Antigen, Infections and Systemic Inflammatory Biomarkers in Early Atherosclerosis in Children and Adolescents with Type 1 Diabetes

Odermarsky, M. LU ; Pesonen, Erkki LU ; Maxedius, Annica LU ; Sorsa, Timo; Pussinen, Pirkko J and Liuba, P. LU (2015) 49th Annual Meeting of the Association for European Paediatric and Congenital Cardiology In Cardiology in the Young 25(Suppl. 1). p.33-33
Abstract
Background: This prospective study focuses on factors associated with arterial damage in children with type 1 diabetes (T1D). Materials and Methods: Eighty children and adolescents with T1D (mean age 15, range: 8-20 yrs; mean diabetes duration 7, range: 0.5 to 19 years) were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. HLA genotypes were determined in dried spots of peripheral blood by polymerase chain reaction followed by hybridization assay. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56... (More)
Background: This prospective study focuses on factors associated with arterial damage in children with type 1 diabetes (T1D). Materials and Methods: Eighty children and adolescents with T1D (mean age 15, range: 8-20 yrs; mean diabetes duration 7, range: 0.5 to 19 years) were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. HLA genotypes were determined in dried spots of peripheral blood by polymerase chain reaction followed by hybridization assay. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.
Results: cIMT progression (% change of cIMT from baseline) correlated inversely with the % changes of both CAC (p = 0.04, r=−0.3, n=62) and FMD (p=0.03, r=−0.3, n=67). RTI frequency correlated significantly with cIMT progression irre- spective of age, diabetes duration, BMI, and HbA1c (p=0.03, r=0.3, in multivariate analysis). When patients were divided in relation to DQ2/8 genotype and RTI, the association of DQ2/8 with cIMT progression remained significant in patients with over three infections/year (p = 0.04, r = 0.3). During follow-up, the group of DQ2/8 patients with CRP > 1 mg/l showed significantly higher levels of plasma MMP-8 than the non-DQ2/8 group.
Conclusions: Diabetes-risk genotype DQ2/8 and inflammation con- tribute to vascular changes in children and adolescents with T1D. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adverse device effect, cardioversion, cerebrovascular accident, child, complication, congenital heart disease, data base, death, device embolization, emergency surgery, female, heart arrest, heart arrhythmia, heart atrium septum defect, hematoma, hospital, human, infant, infection complication, limb, lung insufficiency, major clinical study, pericardial effusion, peroperative complication, pleura effusion, pulmonary hypertension, register, respiratory arrest, resuscitation, retrospective study, safety, surgery, vein occlusion, vein thrombosis
in
Cardiology in the Young
volume
25
issue
Suppl. 1
pages
1 pages
publisher
Cambridge University Press
conference name
49th Annual Meeting of the Association for European Paediatric and Congenital Cardiology
conference location
Prague, Czech Republic
conference dates
2015-05-20 - 2015-05-23
ISSN
1467-1107
DOI
10.1017/S1047951115000529
language
English
LU publication?
yes
id
8a16f882-ff36-4d1b-9f8c-eef5b1cc1789
alternative location
http://www.uni-kiel.de/aepc/2015/aepcAbstractsFinalPrint/O10_6fin.pdf#zoom=100,180,80&toolbar=0&pagemode=none&navpanes=0
date added to LUP
2018-02-03 11:01:39
date last changed
2018-11-21 21:37:50
@misc{8a16f882-ff36-4d1b-9f8c-eef5b1cc1789,
  abstract     = {Background: This prospective study focuses on factors associated with arterial damage in children with type 1 diabetes (T1D). Materials and Methods: Eighty children and adolescents with T1D (mean age 15, range: 8-20 yrs; mean diabetes duration 7, range: 0.5 to 19 years) were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. HLA genotypes were determined in dried spots of peripheral blood by polymerase chain reaction followed by hybridization assay. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients.<br>
Results: cIMT progression (% change of cIMT from baseline) correlated inversely with the % changes of both CAC (p = 0.04, r=−0.3, n=62) and FMD (p=0.03, r=−0.3, n=67). RTI frequency correlated significantly with cIMT progression irre- spective of age, diabetes duration, BMI, and HbA1c (p=0.03, r=0.3, in multivariate analysis). When patients were divided in relation to DQ2/8 genotype and RTI, the association of DQ2/8 with cIMT progression remained significant in patients with over three infections/year (p = 0.04, r = 0.3). During follow-up, the group of DQ2/8 patients with CRP &gt; 1 mg/l showed significantly higher levels of plasma MMP-8 than the non-DQ2/8 group.<br>
Conclusions: Diabetes-risk genotype DQ2/8 and inflammation con- tribute to vascular changes in children and adolescents with T1D.},
  articleno    = {O10-6},
  author       = {Odermarsky, M. and Pesonen, Erkki and Maxedius, Annica and Sorsa, Timo and Pussinen, Pirkko J and Liuba, P.},
  issn         = {1467-1107},
  keyword      = {adverse device effect,cardioversion,cerebrovascular accident,child,complication,congenital heart disease,data base,death,device embolization,emergency surgery,female,heart arrest,heart arrhythmia,heart atrium septum defect,hematoma,hospital,human,infant,infection complication,limb,lung insufficiency,major clinical study,pericardial effusion,peroperative complication,pleura effusion,pulmonary hypertension,register,respiratory arrest,resuscitation,retrospective study,safety,surgery,vein occlusion,vein thrombosis},
  language     = {eng},
  location     = {Prague, Czech Republic},
  month        = {05},
  note         = {Conference Abstract},
  number       = {Suppl. 1},
  pages        = {33--33},
  publisher    = {Cambridge University Press},
  series       = {Cardiology in the Young},
  title        = {Human Leucocyte Antigen, Infections and Systemic Inflammatory Biomarkers in Early Atherosclerosis in Children and Adolescents with Type 1 Diabetes},
  url          = {http://dx.doi.org/10.1017/S1047951115000529},
  volume       = {25},
  year         = {2015},
}