Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Cystine analyses of separate day and night urine as a basis for the management of patients with homozygous cystinuria

Fjellstedt, E LU ; Denneberg, T ; Jeppsson, J O LU ; Christensson, A LU and Tiselius, H G (2001) In Urological Research 29(5). p.10-303
Abstract

Based on previous observations of the diurnal variation of urinary cystine excretion, the use of separate day and night urine collections was proposed. To improve the medical treatment of patients with cystinuria, this strategy was performed to guide the fluid intake and the administration of SH compounds (tiopronin, D-penicillamine, and MESNA).Twenty-six patients (19 treated with SH compounds and seven with alkalinization and hydration only) were followed during two 3.5-year periods. During Period 1, 24-h urine was collected and during Period 2, separate day and night urine was collected. There were 56 episodes of high urinary cystine supersaturation (> 1,200 micromol/l) during Period 2, 47% of which would have evaded detection with... (More)

Based on previous observations of the diurnal variation of urinary cystine excretion, the use of separate day and night urine collections was proposed. To improve the medical treatment of patients with cystinuria, this strategy was performed to guide the fluid intake and the administration of SH compounds (tiopronin, D-penicillamine, and MESNA).Twenty-six patients (19 treated with SH compounds and seven with alkalinization and hydration only) were followed during two 3.5-year periods. During Period 1, 24-h urine was collected and during Period 2, separate day and night urine was collected. There were 56 episodes of high urinary cystine supersaturation (> 1,200 micromol/l) during Period 2, 47% of which would have evaded detection with 24-h urine analysis. In comparison with Period 1, the urinary cystine concentration was lower (P < 0.05), and the urinary volume was higher (P < 0.05) during Period 2. Patients treated with tiopronin had reduced cystine excretion (P < 0.05) and at the end of Period 2, an increased dose of tiopronin, reflecting a more aggressive treatment. Furthermore, a reduced number of stone episodes and need of active stone removal (P < 0.05) was noted in the whole group of patients. Analyses of separate day and night urine samples can be used advantageously to reveal episodes of high supersaturation with cystine not detected in 24-h urine samples. Such a procedure might be useful for optimizing the treatment of patients with cystinuria.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Aged, Circadian Rhythm, Cystinuria/genetics, Dose-Response Relationship, Drug, Female, Homozygote, Humans, Male, Mesna/therapeutic use, Middle Aged, Osmolar Concentration, Penicillamine/therapeutic use, Specimen Handling/methods, Sulfhydryl Compounds/therapeutic use, Tiopronin/administration & dosage, Urinary Calculi/prevention & control
in
Urological Research
volume
29
issue
5
pages
8 pages
publisher
Springer
external identifiers
  • scopus:0035155658
  • pmid:11762791
ISSN
0300-5623
DOI
10.1007/s002400100201
language
English
LU publication?
no
id
8a31318e-08f1-44c9-b952-d519089f99cd
date added to LUP
2019-05-16 13:59:46
date last changed
2024-04-02 02:54:35
@article{8a31318e-08f1-44c9-b952-d519089f99cd,
  abstract     = {{<p>Based on previous observations of the diurnal variation of urinary cystine excretion, the use of separate day and night urine collections was proposed. To improve the medical treatment of patients with cystinuria, this strategy was performed to guide the fluid intake and the administration of SH compounds (tiopronin, D-penicillamine, and MESNA).Twenty-six patients (19 treated with SH compounds and seven with alkalinization and hydration only) were followed during two 3.5-year periods. During Period 1, 24-h urine was collected and during Period 2, separate day and night urine was collected. There were 56 episodes of high urinary cystine supersaturation (&gt; 1,200 micromol/l) during Period 2, 47% of which would have evaded detection with 24-h urine analysis. In comparison with Period 1, the urinary cystine concentration was lower (P &lt; 0.05), and the urinary volume was higher (P &lt; 0.05) during Period 2. Patients treated with tiopronin had reduced cystine excretion (P &lt; 0.05) and at the end of Period 2, an increased dose of tiopronin, reflecting a more aggressive treatment. Furthermore, a reduced number of stone episodes and need of active stone removal (P &lt; 0.05) was noted in the whole group of patients. Analyses of separate day and night urine samples can be used advantageously to reveal episodes of high supersaturation with cystine not detected in 24-h urine samples. Such a procedure might be useful for optimizing the treatment of patients with cystinuria.</p>}},
  author       = {{Fjellstedt, E and Denneberg, T and Jeppsson, J O and Christensson, A and Tiselius, H G}},
  issn         = {{0300-5623}},
  keywords     = {{Adult; Aged; Circadian Rhythm; Cystinuria/genetics; Dose-Response Relationship, Drug; Female; Homozygote; Humans; Male; Mesna/therapeutic use; Middle Aged; Osmolar Concentration; Penicillamine/therapeutic use; Specimen Handling/methods; Sulfhydryl Compounds/therapeutic use; Tiopronin/administration & dosage; Urinary Calculi/prevention & control}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{10--303}},
  publisher    = {{Springer}},
  series       = {{Urological Research}},
  title        = {{Cystine analyses of separate day and night urine as a basis for the management of patients with homozygous cystinuria}},
  url          = {{http://dx.doi.org/10.1007/s002400100201}},
  doi          = {{10.1007/s002400100201}},
  volume       = {{29}},
  year         = {{2001}},
}