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Sertoli cells enhance the survival of co-transplanted dopamine neurons

Willing, A E; Othberg, A I LU ; Saporta, S; Anton, A; Sinibaldi, S; Poulos, S G; Cameron, D F; Freeman, T B and Sanberg, P R (1999) In Brain Research 822(1-2). p.50-246
Abstract

One of the major issues in neural transplantation is the low survival rate (<5%) of transplanted dopamine (DA) neurons [3]. Recently it has been shown that it is possible to enhance the survival of these neurons, which in turn may decrease the amount of tissue that is required for each transplantation patient. The present paper demonstrates a novel approach for enhancing neuronal survival by co-transplantation of neuronal tissue with Testis-derived Sertoli cells (SC). This strategy could improve neuronal survival through the provision of trophic support.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Brain Tissue Transplantation, Cell Communication, Cell Transplantation, Corpus Striatum, Denervation, Dopamine, Graft Survival, Male, Neurons, Oxidopamine, Rats, Rats, Sprague-Dawley, Sertoli Cells, Sympatholytics, Tyrosine 3-Monooxygenase, Journal Article, Research Support, Non-U.S. Gov't
in
Brain Research
volume
822
issue
1-2
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:0033586328
ISSN
0006-8993
DOI
10.1016/S0006-8993(99)01128-2
language
English
LU publication?
no
id
8a6c963f-ed70-4d99-bb3c-c54df77a475e
date added to LUP
2016-12-11 09:57:57
date last changed
2017-01-01 08:42:55
@article{8a6c963f-ed70-4d99-bb3c-c54df77a475e,
  abstract     = {<p>One of the major issues in neural transplantation is the low survival rate (&lt;5%) of transplanted dopamine (DA) neurons [3]. Recently it has been shown that it is possible to enhance the survival of these neurons, which in turn may decrease the amount of tissue that is required for each transplantation patient. The present paper demonstrates a novel approach for enhancing neuronal survival by co-transplantation of neuronal tissue with Testis-derived Sertoli cells (SC). This strategy could improve neuronal survival through the provision of trophic support.</p>},
  author       = {Willing, A E and Othberg, A I and Saporta, S and Anton, A and Sinibaldi, S and Poulos, S G and Cameron, D F and Freeman, T B and Sanberg, P R},
  issn         = {0006-8993},
  keyword      = {Animals,Brain Tissue Transplantation,Cell Communication,Cell Transplantation,Corpus Striatum,Denervation,Dopamine,Graft Survival,Male,Neurons,Oxidopamine,Rats,Rats, Sprague-Dawley,Sertoli Cells,Sympatholytics,Tyrosine 3-Monooxygenase,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {03},
  number       = {1-2},
  pages        = {50--246},
  publisher    = {Elsevier},
  series       = {Brain Research},
  title        = {Sertoli cells enhance the survival of co-transplanted dopamine neurons},
  url          = {http://dx.doi.org/10.1016/S0006-8993(99)01128-2},
  volume       = {822},
  year         = {1999},
}