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Prevalence, concomitant reactions, and factors associated with fragrance allergy in Thailand

Sukakul, Thanisorn LU orcid ; Charoenpipatsin, Norramon ; Svedman, Cecilia LU and Boonchai, Waranya (2021) In Contact Dermatitis 84(3). p.175-182
Abstract

Background: Fragrances are the most common cause of cosmetic contact allergy. Up-to-date information on contact allergy frequencies and relevance aids primary and secondary preventive measures. Objectives: To determine the prevalence, associated factors, and concomitant reactions in fragrance allergy among Thais. Methods: This retrospective study collected data from 2012 to 2019. The patient characteristics of fragrance and nonfragrance allergy groups were compared. Concurrent positive reactions to fragrance allergens (fragrance mix [FM] I, FM II, Myroxylon pereirae resin and hydroxyisohexyl 3-cyclohexene carboxaldehyde) and other baseline-series allergens were analysed. Results: Of 1032 patients, 175 (17.0%) had fragrance allergy, with... (More)

Background: Fragrances are the most common cause of cosmetic contact allergy. Up-to-date information on contact allergy frequencies and relevance aids primary and secondary preventive measures. Objectives: To determine the prevalence, associated factors, and concomitant reactions in fragrance allergy among Thais. Methods: This retrospective study collected data from 2012 to 2019. The patient characteristics of fragrance and nonfragrance allergy groups were compared. Concurrent positive reactions to fragrance allergens (fragrance mix [FM] I, FM II, Myroxylon pereirae resin and hydroxyisohexyl 3-cyclohexene carboxaldehyde) and other baseline-series allergens were analysed. Results: Of 1032 patients, 175 (17.0%) had fragrance allergy, with 57.7% of clinical relevance. FM I showed the highest prevalence (9.4%). The associated factors were being elderly, lesions on the extremities, metal allergy history, and long dermatitis duration. Contact allergies to epoxy resin and Compositae plants were significantly associated with fragrance allergy with an odds ratio of 5.95 (95% confidence interval [CI]: 5.21-6.80) and an odds ratio of 4.42 (95% CI: 1.58-12.36), respectively. No significant associations between colophonium (previously proposed as a fragrance marker) and fragrance allergens were found. Conclusions: The prevalence of fragrance contact allergy remains high and should be considered in old patients presenting with long-standing eczema on the extremities. Unlike reports from other countries, varied, significant, concomitant reactions were observed.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
clinical relevance, Compositae mix II, concomitant patch-test reactions, fragrance allergy, fragrance mix I, fragrance mix II, hydroxyisohexyl 3-cyclohexene carboxaldehyde, Myroxylon pereirae resin (balsam of Peru), prevalence
in
Contact Dermatitis
volume
84
issue
3
pages
175 - 182
publisher
Wiley-Blackwell
external identifiers
  • scopus:85096698964
  • pmid:33075139
ISSN
0105-1873
DOI
10.1111/cod.13723
language
English
LU publication?
yes
id
8a72a42a-e7d0-4def-acd9-9776bbf80197
date added to LUP
2020-12-07 14:00:40
date last changed
2024-06-13 01:14:16
@article{8a72a42a-e7d0-4def-acd9-9776bbf80197,
  abstract     = {{<p>Background: Fragrances are the most common cause of cosmetic contact allergy. Up-to-date information on contact allergy frequencies and relevance aids primary and secondary preventive measures. Objectives: To determine the prevalence, associated factors, and concomitant reactions in fragrance allergy among Thais. Methods: This retrospective study collected data from 2012 to 2019. The patient characteristics of fragrance and nonfragrance allergy groups were compared. Concurrent positive reactions to fragrance allergens (fragrance mix [FM] I, FM II, Myroxylon pereirae resin and hydroxyisohexyl 3-cyclohexene carboxaldehyde) and other baseline-series allergens were analysed. Results: Of 1032 patients, 175 (17.0%) had fragrance allergy, with 57.7% of clinical relevance. FM I showed the highest prevalence (9.4%). The associated factors were being elderly, lesions on the extremities, metal allergy history, and long dermatitis duration. Contact allergies to epoxy resin and Compositae plants were significantly associated with fragrance allergy with an odds ratio of 5.95 (95% confidence interval [CI]: 5.21-6.80) and an odds ratio of 4.42 (95% CI: 1.58-12.36), respectively. No significant associations between colophonium (previously proposed as a fragrance marker) and fragrance allergens were found. Conclusions: The prevalence of fragrance contact allergy remains high and should be considered in old patients presenting with long-standing eczema on the extremities. Unlike reports from other countries, varied, significant, concomitant reactions were observed.</p>}},
  author       = {{Sukakul, Thanisorn and Charoenpipatsin, Norramon and Svedman, Cecilia and Boonchai, Waranya}},
  issn         = {{0105-1873}},
  keywords     = {{clinical relevance; Compositae mix II; concomitant patch-test reactions; fragrance allergy; fragrance mix I; fragrance mix II; hydroxyisohexyl 3-cyclohexene carboxaldehyde; Myroxylon pereirae resin (balsam of Peru); prevalence}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{175--182}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Prevalence, concomitant reactions, and factors associated with fragrance allergy in Thailand}},
  url          = {{http://dx.doi.org/10.1111/cod.13723}},
  doi          = {{10.1111/cod.13723}},
  volume       = {{84}},
  year         = {{2021}},
}