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Ingestion of gallium phosphide nanowires has no adverse effect on Drosophila tissue function.

Adolfsson, Karl LU ; Schneider, Martina LU ; Hammarin, Greger; Häcker, Udo LU and Prinz, Christelle LU (2013) In Nanotechnology 24(28).
Abstract
Engineered nanoparticles have been under increasing scrutiny in recent years. High aspect ratio nanoparticles such as carbon nanotubes and nanowires have raised safety concerns due to their geometrical similarity to asbestos fibers. III-V epitaxial semiconductor nanowires are expected to be utilized in devices such as LEDs and solar cells and will thus be available to the public. In addition, clean-room staff fabricating and characterizing the nanowires are at risk of exposure, emphasizing the importance of investigating their possible toxicity. Here we investigated the effects of gallium phosphide nanowires on the fruit fly Drosophila melanogaster. Drosophila larvae and/or adults were exposed to gallium phosphide nanowires by ingestion... (More)
Engineered nanoparticles have been under increasing scrutiny in recent years. High aspect ratio nanoparticles such as carbon nanotubes and nanowires have raised safety concerns due to their geometrical similarity to asbestos fibers. III-V epitaxial semiconductor nanowires are expected to be utilized in devices such as LEDs and solar cells and will thus be available to the public. In addition, clean-room staff fabricating and characterizing the nanowires are at risk of exposure, emphasizing the importance of investigating their possible toxicity. Here we investigated the effects of gallium phosphide nanowires on the fruit fly Drosophila melanogaster. Drosophila larvae and/or adults were exposed to gallium phosphide nanowires by ingestion with food. The toxicity and tissue interaction of the nanowires was evaluated by investigating tissue distribution, activation of immune response, genome-wide gene expression, life span, fecundity and somatic mutation rates. Our results show that gallium phosphide nanowires applied through the diet are not taken up into Drosophila tissues, do not elicit a measurable immune response or changes in genome-wide gene expression and do not significantly affect life span or somatic mutation rate. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nanotechnology
volume
24
issue
28
publisher
IOP Publishing
external identifiers
  • wos:000320775500001
  • pmid:23787695
  • scopus:84879544236
ISSN
0957-4484
DOI
10.1088/0957-4484/24/28/285101
language
English
LU publication?
yes
id
8a7450ff-c34c-4428-8a96-1bf9c601c1ee (old id 3913105)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23787695?dopt=Abstract
date added to LUP
2013-07-01 15:00:41
date last changed
2018-11-21 19:43:09
@article{8a7450ff-c34c-4428-8a96-1bf9c601c1ee,
  abstract     = {Engineered nanoparticles have been under increasing scrutiny in recent years. High aspect ratio nanoparticles such as carbon nanotubes and nanowires have raised safety concerns due to their geometrical similarity to asbestos fibers. III-V epitaxial semiconductor nanowires are expected to be utilized in devices such as LEDs and solar cells and will thus be available to the public. In addition, clean-room staff fabricating and characterizing the nanowires are at risk of exposure, emphasizing the importance of investigating their possible toxicity. Here we investigated the effects of gallium phosphide nanowires on the fruit fly Drosophila melanogaster. Drosophila larvae and/or adults were exposed to gallium phosphide nanowires by ingestion with food. The toxicity and tissue interaction of the nanowires was evaluated by investigating tissue distribution, activation of immune response, genome-wide gene expression, life span, fecundity and somatic mutation rates. Our results show that gallium phosphide nanowires applied through the diet are not taken up into Drosophila tissues, do not elicit a measurable immune response or changes in genome-wide gene expression and do not significantly affect life span or somatic mutation rate.},
  articleno    = {285101},
  author       = {Adolfsson, Karl and Schneider, Martina and Hammarin, Greger and Häcker, Udo and Prinz, Christelle},
  issn         = {0957-4484},
  language     = {eng},
  number       = {28},
  publisher    = {IOP Publishing},
  series       = {Nanotechnology},
  title        = {Ingestion of gallium phosphide nanowires has no adverse effect on Drosophila tissue function.},
  url          = {http://dx.doi.org/10.1088/0957-4484/24/28/285101},
  volume       = {24},
  year         = {2013},
}