Deep Time Paleoproteomics : Looking Forward
(2022) In Journal of Proteome Research 21(1). p.9-19- Abstract
The goal of paleoproteomics is to characterize proteins from specimens that have been subjected to the degrading and obscuring effects of time, thus obtaining biological information about tissues or organisms both unobservable in the present and unobtainable through morphological study. Although the description of sequences from Tyrannosaurus rex and Brachylophosaurus canadensis suggested that proteins may persist over tens of millions of years, the majority of paleoproteomic analyses have focused on historical, archeological, or relatively young paleontological samples that rarely exceed 1 million years in age. However, recent advances in methodology and analyses of diverse tissues types (e.g., fossil eggshell, dental enamel) have... (More)
The goal of paleoproteomics is to characterize proteins from specimens that have been subjected to the degrading and obscuring effects of time, thus obtaining biological information about tissues or organisms both unobservable in the present and unobtainable through morphological study. Although the description of sequences from Tyrannosaurus rex and Brachylophosaurus canadensis suggested that proteins may persist over tens of millions of years, the majority of paleoproteomic analyses have focused on historical, archeological, or relatively young paleontological samples that rarely exceed 1 million years in age. However, recent advances in methodology and analyses of diverse tissues types (e.g., fossil eggshell, dental enamel) have begun closing the large window of time that remains unexplored in the fossil history of the Cenozoic. In this perspective, we discuss the history and current state of deep time paleoproteomics (DTPp), here defined as paleoproteomic study of samples ∼1 million years (1 Ma) or more in age. We then discuss the future of DTPp research, including what we see as critical ways the field can expand, advancements in technology that can be utilized, and the types of questions DTPp can address if such a future is realized.
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- author
- Schroeter, Elena R. ; Cleland, Timothy P. and Schweitzer, Mary H. LU
- organization
- publishing date
- 2022-01-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- deep time, dinosaurs, eggshell, enamel, paleoproteomics
- in
- Journal of Proteome Research
- volume
- 21
- issue
- 1
- pages
- 11 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- scopus:85121911675
- pmid:34918935
- ISSN
- 1535-3893
- DOI
- 10.1021/acs.jproteome.1c00755
- language
- English
- LU publication?
- yes
- additional info
- Funding Information: This project was generously supported by the Department of Biological Sciences at North Carolina State University (ERS), Smithsonian’s Museum Conservation Institute Federal and Trust Funds (TPC), NSF EAR-1344198, a grant from the David and Lucille Packard Foundation, and donations from Immunitas Therapeutics, Franklin M. and Susan P. Orr, Vance and Gail Mullis (MHS). We thank Paul Haynes and two anonymous reviewers whose comments greatly improved this manuscript. Funding Information: This project was generously supported by the Department of Biological Sciences at North Carolina State University (ERS), Smithsonian?s Museum Conservation Institute Federal and Trust Funds (TPC), NSF EAR-1344198, a grant from the David and Lucille Packard Foundation, and donations from Immunitas Therapeutics, Franklin M. and Susan P. Orr, Vance and Gail Mullis (MHS). We thank Paul Haynes and two anonymous reviewers whose comments greatly improved this manuscript. Publisher Copyright: © 2021 American Chemical Society
- id
- 8a7781dc-fd34-4c16-ad09-74a9ed25c498
- date added to LUP
- 2022-01-30 13:19:11
- date last changed
- 2024-04-20 19:52:01
@article{8a7781dc-fd34-4c16-ad09-74a9ed25c498,
abstract = {{<p>The goal of paleoproteomics is to characterize proteins from specimens that have been subjected to the degrading and obscuring effects of time, thus obtaining biological information about tissues or organisms both unobservable in the present and unobtainable through morphological study. Although the description of sequences from Tyrannosaurus rex and Brachylophosaurus canadensis suggested that proteins may persist over tens of millions of years, the majority of paleoproteomic analyses have focused on historical, archeological, or relatively young paleontological samples that rarely exceed 1 million years in age. However, recent advances in methodology and analyses of diverse tissues types (e.g., fossil eggshell, dental enamel) have begun closing the large window of time that remains unexplored in the fossil history of the Cenozoic. In this perspective, we discuss the history and current state of deep time paleoproteomics (DTPp), here defined as paleoproteomic study of samples ∼1 million years (1 Ma) or more in age. We then discuss the future of DTPp research, including what we see as critical ways the field can expand, advancements in technology that can be utilized, and the types of questions DTPp can address if such a future is realized.</p>}},
author = {{Schroeter, Elena R. and Cleland, Timothy P. and Schweitzer, Mary H.}},
issn = {{1535-3893}},
keywords = {{deep time; dinosaurs; eggshell; enamel; paleoproteomics}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{9--19}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Journal of Proteome Research}},
title = {{Deep Time Paleoproteomics : Looking Forward}},
url = {{http://dx.doi.org/10.1021/acs.jproteome.1c00755}},
doi = {{10.1021/acs.jproteome.1c00755}},
volume = {{21}},
year = {{2022}},
}