CD4+CD57+ T cells derived from peripheral blood do not support immunoglobulin production by B cells
(1995) In Cellular Immunology 163(2). p.245-253- Abstract
A small subpopulation of CD4+ T cells found in peripheral blood coexpresses the CD57+ marker normally found on, e.g., NK cells. It is known that this population occurs in a higher frequency in certain diseases. The same antigen has also been shown to be expressed on CD4+ T cells derived from germinal centers. The localization of this cell population to specialized lymphoid structures suggests that it may play a role in the evolution of the antibody response following antigenic stimulation in vivo. We have examined the ability of peripheral blood helper T cells coexpressing CD57 to participate in B cell activation/differentiation and evaluated their responses to polyclonal stimulation. The... (More)
A small subpopulation of CD4+ T cells found in peripheral blood coexpresses the CD57+ marker normally found on, e.g., NK cells. It is known that this population occurs in a higher frequency in certain diseases. The same antigen has also been shown to be expressed on CD4+ T cells derived from germinal centers. The localization of this cell population to specialized lymphoid structures suggests that it may play a role in the evolution of the antibody response following antigenic stimulation in vivo. We have examined the ability of peripheral blood helper T cells coexpressing CD57 to participate in B cell activation/differentiation and evaluated their responses to polyclonal stimulation. The CD4+CD57+ T cells do not express mRNA for a number of different cytokines or for the CD40 ligand after activation in vitro. Furthermore these cells do not induce differentiation of B cells into immunoglobulin-producing cells. Consequently, despite their CD4 phenotype and their ability to be activated, to express the IL-2 receptor, and to enter into the cell cycle, they do not act as T helper cells under conditions where CD4+/CD57- cells normally do so. The findings suggest that this peripheral blood helper T cell population is functionally different from regular CD4+ T cells. The basis for the lack of proper costimulatory signals for immunoglobulin production might be related to the low expression of CD28.
(Less)
- author
- Andersson, Eva LU ; Ohlin, Mats LU ; Borrebaeck, Carl A K LU and Carlsson, Roland LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- in
- Cellular Immunology
- volume
- 163
- issue
- 2
- pages
- 9 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:0028998009
- pmid:7541727
- ISSN
- 0008-8749
- DOI
- 10.1006/cimm.1995.1123
- language
- English
- LU publication?
- yes
- id
- 8ac958c8-4be0-4551-ab8d-2579f91ef1bc
- date added to LUP
- 2016-04-19 14:11:51
- date last changed
- 2024-01-04 02:22:13
@article{8ac958c8-4be0-4551-ab8d-2579f91ef1bc, abstract = {{<p>A small subpopulation of CD4<sup>+</sup> T cells found in peripheral blood coexpresses the CD57<sup>+</sup> marker normally found on, e.g., NK cells. It is known that this population occurs in a higher frequency in certain diseases. The same antigen has also been shown to be expressed on CD4<sup>+</sup> T cells derived from germinal centers. The localization of this cell population to specialized lymphoid structures suggests that it may play a role in the evolution of the antibody response following antigenic stimulation in vivo. We have examined the ability of peripheral blood helper T cells coexpressing CD57 to participate in B cell activation/differentiation and evaluated their responses to polyclonal stimulation. The CD4<sup>+</sup>CD57<sup>+</sup> T cells do not express mRNA for a number of different cytokines or for the CD40 ligand after activation in vitro. Furthermore these cells do not induce differentiation of B cells into immunoglobulin-producing cells. Consequently, despite their CD4 phenotype and their ability to be activated, to express the IL-2 receptor, and to enter into the cell cycle, they do not act as T helper cells under conditions where CD4<sup>+</sup>/CD57<sup>-</sup> cells normally do so. The findings suggest that this peripheral blood helper T cell population is functionally different from regular CD4<sup>+</sup> T cells. The basis for the lack of proper costimulatory signals for immunoglobulin production might be related to the low expression of CD28.</p>}}, author = {{Andersson, Eva and Ohlin, Mats and Borrebaeck, Carl A K and Carlsson, Roland}}, issn = {{0008-8749}}, language = {{eng}}, number = {{2}}, pages = {{245--253}}, publisher = {{Elsevier}}, series = {{Cellular Immunology}}, title = {{CD4+CD57+ T cells derived from peripheral blood do not support immunoglobulin production by B cells}}, url = {{http://dx.doi.org/10.1006/cimm.1995.1123}}, doi = {{10.1006/cimm.1995.1123}}, volume = {{163}}, year = {{1995}}, }