Metabolic profiles in children during fasting
(2011) In Pediatrics 127(4).- Abstract
BACKGROUND: Hypoglycemia is one of the most common metabolic derangements in childhood. To establish the cause of hypoglycemia, fasting tolerance tests can be used. Currently available reference values for fasting tolerance tests have limitations in their use in daily practice. OBJECTIVE: The aim of this study was to determine the reference values of metabolites involved in glucose homeostasis during fasting in healthy children. METHODS: This study included a retrospective analysis of 488 fasting tests. All tests of patients (n = 321) with disorders, including metabolic and endocrine disorders, were excluded, as were tests performed in children who were over-or underweight. RESULTS: In 167 fasting tests performed in the study,... (More)
BACKGROUND: Hypoglycemia is one of the most common metabolic derangements in childhood. To establish the cause of hypoglycemia, fasting tolerance tests can be used. Currently available reference values for fasting tolerance tests have limitations in their use in daily practice. OBJECTIVE: The aim of this study was to determine the reference values of metabolites involved in glucose homeostasis during fasting in healthy children. METHODS: This study included a retrospective analysis of 488 fasting tests. All tests of patients (n = 321) with disorders, including metabolic and endocrine disorders, were excluded, as were tests performed in children who were over-or underweight. RESULTS: In 167 fasting tests performed in the study, hypoglycemia was reached in 52 (31%) tests. On the basis of the time until hypoglycemia was reached, 3 age groups could be defined: (1) children aged 0 to 24 months (median 15 months) (n = 49); (2) children aged 25 to 84 months (median 45 months) (n = 79); (3) and children aged 85 to 216 months (median 106 months) (n = 39). In all groups, a significant increase in ketone body levels and a significant decrease in glucose levels in plasma were observed during fasting. Younger children had a faster increase in ketone body levels and a faster decrease in glucose levels in plasma than older children. CONCLUSIONS: Reference values of the metabolites involved in glucose homeostasis during fasting in children were generated. Those values can be used to determine whether a child has a normal fasting response. For high-risk children, guidelines concerning maximum fasting time and dietary intervention during illness are of the utmost importance.
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- author
- Van Veen, Merel R. ; Van Hasselt, Peter M. ; De Sain-van Der Velden, Monique G.M. ; Verhoeven, Nanda ; Hofstede, Floris C. ; De Koning, Tom J. LU and Visser, Gepke
- publishing date
- 2011-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Fatty acids, Hypoglycemia, Metabolism
- in
- Pediatrics
- volume
- 127
- issue
- 4
- publisher
- American Academy of Pediatrics
- external identifiers
-
- scopus:79953331773
- pmid:21422093
- ISSN
- 0031-4005
- DOI
- 10.1542/peds.2010-1706
- language
- English
- LU publication?
- no
- id
- 8afe33d9-92ad-4a39-9db6-ec03ce8094eb
- date added to LUP
- 2020-02-26 10:21:10
- date last changed
- 2024-06-27 14:58:43
@article{8afe33d9-92ad-4a39-9db6-ec03ce8094eb,
abstract = {{<p>BACKGROUND: Hypoglycemia is one of the most common metabolic derangements in childhood. To establish the cause of hypoglycemia, fasting tolerance tests can be used. Currently available reference values for fasting tolerance tests have limitations in their use in daily practice. OBJECTIVE: The aim of this study was to determine the reference values of metabolites involved in glucose homeostasis during fasting in healthy children. METHODS: This study included a retrospective analysis of 488 fasting tests. All tests of patients (n = 321) with disorders, including metabolic and endocrine disorders, were excluded, as were tests performed in children who were over-or underweight. RESULTS: In 167 fasting tests performed in the study, hypoglycemia was reached in 52 (31%) tests. On the basis of the time until hypoglycemia was reached, 3 age groups could be defined: (1) children aged 0 to 24 months (median 15 months) (n = 49); (2) children aged 25 to 84 months (median 45 months) (n = 79); (3) and children aged 85 to 216 months (median 106 months) (n = 39). In all groups, a significant increase in ketone body levels and a significant decrease in glucose levels in plasma were observed during fasting. Younger children had a faster increase in ketone body levels and a faster decrease in glucose levels in plasma than older children. CONCLUSIONS: Reference values of the metabolites involved in glucose homeostasis during fasting in children were generated. Those values can be used to determine whether a child has a normal fasting response. For high-risk children, guidelines concerning maximum fasting time and dietary intervention during illness are of the utmost importance.</p>}},
author = {{Van Veen, Merel R. and Van Hasselt, Peter M. and De Sain-van Der Velden, Monique G.M. and Verhoeven, Nanda and Hofstede, Floris C. and De Koning, Tom J. and Visser, Gepke}},
issn = {{0031-4005}},
keywords = {{Fatty acids; Hypoglycemia; Metabolism}},
language = {{eng}},
month = {{04}},
number = {{4}},
publisher = {{American Academy of Pediatrics}},
series = {{Pediatrics}},
title = {{Metabolic profiles in children during fasting}},
url = {{http://dx.doi.org/10.1542/peds.2010-1706}},
doi = {{10.1542/peds.2010-1706}},
volume = {{127}},
year = {{2011}},
}