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TFEB: Pathogenic role and therapeutic target in Parkinson disease.

Decressac, Mickael LU and Björklund, Anders LU (2013) In Autophagy 9(8). p.1244-1246
Abstract
Parkinson disease (PD) is characterized by the progressive loss of nigral dopamine neurons and the presence of accumulations containing the disease-causing protein SNCA/α-synuclein. Here we review our recent findings describing how SNCA impairs the function of the master regulator of the autophagy-lysosomal pathway (ALP), the transcription factor EB (TFEB), and that genetic or pharmacological stimulation of its activity promotes protection of dopamine neurons. These findings suggest that strategies aimed at enhancing autophagy-mediated degradation of SNCA may hold great promise for disease intervention in PD.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Autophagy
volume
9
issue
8
pages
1244 - 1246
publisher
Landes Bioscience
external identifiers
  • wos:000323314600011
  • pmid:23715007
  • scopus:84882950362
ISSN
1554-8635
DOI
10.4161/auto.25044
language
English
LU publication?
yes
id
8b449b2c-ef07-4669-8799-ea2cccf2e839 (old id 3804059)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23715007?dopt=Abstract
date added to LUP
2013-06-05 15:11:30
date last changed
2019-04-10 01:20:14
@article{8b449b2c-ef07-4669-8799-ea2cccf2e839,
  abstract     = {Parkinson disease (PD) is characterized by the progressive loss of nigral dopamine neurons and the presence of accumulations containing the disease-causing protein SNCA/α-synuclein. Here we review our recent findings describing how SNCA impairs the function of the master regulator of the autophagy-lysosomal pathway (ALP), the transcription factor EB (TFEB), and that genetic or pharmacological stimulation of its activity promotes protection of dopamine neurons. These findings suggest that strategies aimed at enhancing autophagy-mediated degradation of SNCA may hold great promise for disease intervention in PD.},
  author       = {Decressac, Mickael and Björklund, Anders},
  issn         = {1554-8635},
  language     = {eng},
  number       = {8},
  pages        = {1244--1246},
  publisher    = {Landes Bioscience},
  series       = {Autophagy},
  title        = {TFEB: Pathogenic role and therapeutic target in Parkinson disease.},
  url          = {http://dx.doi.org/10.4161/auto.25044},
  volume       = {9},
  year         = {2013},
}