Differential expression of anti-Müllerian hormone (amh) and anti-Müllerian hormone receptor type II (amhrII) in the teleost medaka
(2007) In Developmental Dynamics 236(1). p.271-281- Abstract
- Abstract 10.1002/dvdy.20997.abs In mammals, the anti-Müllerian hormone (Amh) is responsible for the regression of the Müllerian ducts; therefore, Amh is an important factor of male sex differentiation. The amh gene has been cloned in various vertebrates, as well as in several teleost species. To date, all described species show a sexually dimorphic expression of amh during sex differentiation or at least in differentiated juvenile gonads. We have identified the medaka amh ortholog and examined its expression pattern. Medaka amh shows no sexually dimorphic expression pattern. It is expressed in both developing XY male and XX female gonads. In adult testes, amh is expressed in the Sertoli cells and in adult ovaries in granulosa cells... (More)
- Abstract 10.1002/dvdy.20997.abs In mammals, the anti-Müllerian hormone (Amh) is responsible for the regression of the Müllerian ducts; therefore, Amh is an important factor of male sex differentiation. The amh gene has been cloned in various vertebrates, as well as in several teleost species. To date, all described species show a sexually dimorphic expression of amh during sex differentiation or at least in differentiated juvenile gonads. We have identified the medaka amh ortholog and examined its expression pattern. Medaka amh shows no sexually dimorphic expression pattern. It is expressed in both developing XY male and XX female gonads. In adult testes, amh is expressed in the Sertoli cells and in adult ovaries in granulosa cells surrounding the oocytes, like in mammals. To better understand the function of amh, we cloned the anti-Müllerian hormone receptor type II (amhrII) ortholog and compared its expression pattern with amh, aromatase (cyp19a1), and scp3. During gonad development, amhrII is coexpressed with medaka amh in somatic cells of the gonads and shows no sexually dimorphic expression. Only the expression level of the Amh type II receptor gene was decreased noticeably in adult female gonads. These results suggest that medaka Amh and AmhrII are involved in gonad formation and maintenance in both sexes. Developmental Dynamics 236:271–281, 2007. © 2006 Wiley-Liss, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1787899
- author
- Klüver, Nils ; Pfennig, Frank ; Pala, Irene LU ; Storch, Katja ; Schlieder, Marlen ; Froschauer, Alexander ; Gutzeit, Herwig O. and Schartl, Manfred
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- medaka, MIS, gonad development, AmhrII, Amh type II receptor, anti-Müllerian hormone, Amh, sex determination, sex differentiation
- in
- Developmental Dynamics
- volume
- 236
- issue
- 1
- pages
- 271 - 281
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:33846219589
- ISSN
- 1097-0177
- DOI
- 10.1002/dvdy.20997
- language
- English
- LU publication?
- no
- id
- 8b4d0a22-0781-4cd4-be85-4ced41363e1c (old id 1787899)
- alternative location
- http://dx.doi.org/10.1002/dvdy.20997
- date added to LUP
- 2016-04-01 12:03:59
- date last changed
- 2022-04-29 00:12:27
@article{8b4d0a22-0781-4cd4-be85-4ced41363e1c, abstract = {{Abstract 10.1002/dvdy.20997.abs In mammals, the anti-Müllerian hormone (Amh) is responsible for the regression of the Müllerian ducts; therefore, Amh is an important factor of male sex differentiation. The amh gene has been cloned in various vertebrates, as well as in several teleost species. To date, all described species show a sexually dimorphic expression of amh during sex differentiation or at least in differentiated juvenile gonads. We have identified the medaka amh ortholog and examined its expression pattern. Medaka amh shows no sexually dimorphic expression pattern. It is expressed in both developing XY male and XX female gonads. In adult testes, amh is expressed in the Sertoli cells and in adult ovaries in granulosa cells surrounding the oocytes, like in mammals. To better understand the function of amh, we cloned the anti-Müllerian hormone receptor type II (amhrII) ortholog and compared its expression pattern with amh, aromatase (cyp19a1), and scp3. During gonad development, amhrII is coexpressed with medaka amh in somatic cells of the gonads and shows no sexually dimorphic expression. Only the expression level of the Amh type II receptor gene was decreased noticeably in adult female gonads. These results suggest that medaka Amh and AmhrII are involved in gonad formation and maintenance in both sexes. Developmental Dynamics 236:271–281, 2007. © 2006 Wiley-Liss, Inc.}}, author = {{Klüver, Nils and Pfennig, Frank and Pala, Irene and Storch, Katja and Schlieder, Marlen and Froschauer, Alexander and Gutzeit, Herwig O. and Schartl, Manfred}}, issn = {{1097-0177}}, keywords = {{medaka; MIS; gonad development; AmhrII; Amh type II receptor; anti-Müllerian hormone; Amh; sex determination; sex differentiation}}, language = {{eng}}, number = {{1}}, pages = {{271--281}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Developmental Dynamics}}, title = {{Differential expression of anti-Müllerian hormone (amh) and anti-Müllerian hormone receptor type II (amhrII) in the teleost medaka}}, url = {{http://dx.doi.org/10.1002/dvdy.20997}}, doi = {{10.1002/dvdy.20997}}, volume = {{236}}, year = {{2007}}, }